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Liquid metal as reconnection agent for peripheral nerve injury
2016
Science Bulletin
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The nerve signals detected was found to be almost the same as those from the complete nerve, where the negative bursting firing caused by PNI was absent on the neural discharge curve after nerve-reconnection ...
In vivo experiments were performed, in which transected sciatic nerve of mouse was reconnected by liquid metal gallium. ...
Acknowledgments This work was supported by the National Natural Science Foundation of China (51376102) and the China Postdoctoral Science Foundation. ...
doi:10.1007/s11434-016-1090-2
fatcat:kx62xrc6ffdklacy6dqj7fpswe
Tissue Engineering Strategies for Peripheral Nerve Regeneration
2021
Frontiers in Neurology
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A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. ...
Given the complexity of nerve regeneration, this review summarizes the pathophysiology and tissue-engineered repairing strategies of the PNI. ...
That is because the nerve injury causes double damage. After PNI, muscle denervation causes atrophy and loss of original function. ...
doi:10.3389/fneur.2021.768267
pmid:34867754
pmcid:PMC8635143
fatcat:xwch2355kncyhaq6euujnxmwne
A clinical approach of neuropathic pain in piriformis syndrome: case presentation and rehabilitation particularities
2020
Balneo Research Journal
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We present the case of a patient with posttraumatic piriformis syndrome who came to our department with significant pain and muscle weakness. ...
Piriformis syndrome is a rare cause of sciatica and buttock pain and is usually considered as a diagnosis of exclusion for patients with a history of trauma. ...
For a long period of time it was wrongly thought that sciatica is only caused by the compression of the sciatic nerve by a protruding intervertebral disc. ...
doi:10.12680/balneo.2020.408
fatcat:gxusu4mw45buthu6dyyud7gn7m
Effects of Electrical Stimulation on Peripheral Nerve Regeneration in a Silicone Rubber Conduit in Taxol-Treated Rats
2020
Materials
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It was aimed to determine the effects of electrical stimulation at various frequencies on regeneration of the sciatic nerves in the bridging conduits. ...
This study suggested that low- (2 Hz) to medium-frequency (20 Hz) electrical stimulation could ameliorate local inflammatory conditions to augment recovery of regenerating nerves by accelerating their ...
The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. ...
doi:10.3390/ma13051063
pmid:32120862
fatcat:d5iuedd2tbajlknkl57znehlby
Electrical Stimulation for Nervous System Injury: Research Progress and Prospects
2020
Wuli huaxue xuebao
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This review summarizes the progress in research on EFs on neurons and applications of EFs in the treatment of peripheral nerve system and central nerve system injuries, focusing on the methods and effects ...
Electrical stimulation has been applied by researchers to induce nerve repair. ...
By copying the micro-nano morphology on the surface of natural plants, an interlocking microstructure is formed on the friction layer to enhance the triboelectric effect by Wu's team 65 . ...
doi:10.3866/pku.whxb202005038
fatcat:qunqra2ejza27plpksostm3exm
Acceleration of Peripheral Nerve Regeneration through Asymmetrically Porous Nerve Guide Conduit Applied with Biological/Physical Stimulation
2013
Tissue Engineering. Part A
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The NGC group that received dual stimulation (NGF and US) showed more effective nerve regeneration behavior than the groups that received a single stimulation (NGF or US). ...
The animal study revealed that each stimulation (NGF or US) has a positive effect to promote the peripheral nerve regeneration through the NGC, however, the US-stimulated NGC group allowed more accelerated ...
Acknowledgment This study was supported by the Midcareer Research Program through a grant from the National Research Foundation (NRF) of Korea (No. 2011-0000244). ...
doi:10.1089/ten.tea.2012.0735
pmid:23859225
pmcid:PMC3856603
fatcat:5cysxltp35h4reghxf77a2cfuy
Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections
2008
BMC Biotechnology
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Four months after surgery, sciatic nerves failed to reconnect the two stumps of transected nerves in the control animal group. ...
In most of the treated animals the electrospun tubes induced nervous regeneration and functional reconnection of the two severed sciatic nerve tracts. ...
Rutledge and financial support from the Nicholas G. and Dorothea K. Dumbros Fellowship fund and the U.S. Army under contract DAAD-19-02-D-0002 with the U.S. Army Office. ...
doi:10.1186/1472-6750-8-39
pmid:18405347
pmcid:PMC2358889
fatcat:t5atvmsafbajnixxn3mluslp2q
The success of biomaterial-based tissue engineering strategies for peripheral nerve regeneration
2022
Frontiers in Bioengineering and Biotechnology
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Peripheral nerve injury is a clinically common injury that causes sensory dysfunction and locomotor system degeneration, which seriously affects the quality of the patients' daily life. ...
Long gapped defects in large nerve are difficult to repair via surgery and limited donor source of autologous nerve greatly challenges the successful nerve repair by transplantation. ...
In addition, many types of physical or chemical stimulation, such as pH, optical signal, and electric current, can also promote nerve repair by activating the release of bioactive factors in neural cells ...
doi:10.3389/fbioe.2022.1039777
fatcat:lfa5s3yzznal7n3w22xaxuezp4
Biomaterials for the Development of Peripheral Nerve Guidance Conduits
2012
Tissue engineering. Part B, Reviews
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Thus, the development of a nerve guidance conduit, which could match the effectiveness of the autologous nerve graft, would be beneficial to the field of peripheral nerve surgery. ...
Currently, surgical treatments for peripheral nerve injury are less than satisfactory. ...
They thank the Tissue Engineering Resource Center (TERC) through the NIH (P41EB002520) from the National Institute of Biomedical Imaging and Bioengineering, and the Armed Forces Institute for Regenerative ...
doi:10.1089/ten.teb.2011.0240
pmid:21812591
pmcid:PMC3262974
fatcat:rr3jpizhrffkvlzpulz3uy5dee
A comparison of the performance of mono- and bi-component electrospun conduits in a rat sciatic model
2014
Biomaterials
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However, in vivo studies in rat sciatic nerve defect model show an opposite response: MC conduits stimulate superior nerve regeneration than gelatin containing PCL conduits as confirmed by electrophysiology ...
However, the efficiency of synthetic nerve conduits is often compromised by the lack of molecular factors to create an enriched microenvironment for nerve regeneration. ...
Scanning Electron Microscopy was supported by the Transmission and Scanning Electron Microscopy Labs (LAMEST) of the National Research Council of Italy. ...
doi:10.1016/j.biomaterials.2014.07.010
pmid:25085857
pmcid:PMC4618796
fatcat:f26i7gdzbrfsxjl37wjstih25m
Morphological Regeneration and Functional Recovery of Neuromuscular Junctions after Tourniquet-Induced Injuries in Mouse Hindlimb
2017
Frontiers in Physiology
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Tourniquet application and its subsequent release cause serious injuries to the skeletal muscle, nerve, and neuromuscular junction (NMJ) due to mechanical compression and ischemia-reperfusion (IR). ...
During 3 h of tourniquet application and varied periods of tourniquet release, NMJs in the gastrocnemius muscle were characterized by morphological and functional changes. ...
Nevertheless, by comparing the structure of the NMJ and sciatic nerve-stimulated EPPs at different periods of tourniquet release after 3 h of tourniquet application, the current study confirmed the correlation ...
doi:10.3389/fphys.2017.00207
pmid:28428759
pmcid:PMC5382216
fatcat:vh7dcnvizvakdkk3ppt5b62fzm
Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art
[chapter]
2017
Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications
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Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic ...
In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and ...
Acknowledgements This research was supported by Programa Operacional Regional do Norte (ON.2-O Novo Norte), QREN, FEDER with the project 'iBone Therapies: Terapias inovadoras para a regeneração óssea', ...
doi:10.5772/intechopen.69540
fatcat:ms7brcutrvcknlmmbwskqf6qyq
Spinal cord injury and physical activity: preservation of the body
2011
Spinal Cord
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Objectives: The objective of this review was to examine the evidence for the effects of physical rehabilitation strategies on health and fitness, and maintenance of target systems below the level of injury ...
Issues requiring further investigation include identification of the optimum dosage of interventions to achieve specific goals, for example, prevention of muscle atrophy and osteoporosis, and development ...
that although electrical stimulation enhanced regeneration of the sciatic nerve in rats, it also increased the number of misdirected axons. ...
doi:10.1038/sc.2011.149
pmid:22158253
fatcat:6tlmhhthkfbrtnzkkp3dsmqg7m
Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury
2020
Frontiers in Neurology
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Resection of a tibial nerve segment with subsequent electrode implantation on the dorsal surfaces of the gastrocnemius muscle was performed on ten Lewis rats. ...
The success of devices delivering functional electrical stimulation (FES) has been hindered by complications related to implants including skin breakdown and subsequent wound dehiscence. ...
All authors contributed to manuscript revision, read, and approved the submitted version. ...
doi:10.3389/fneur.2020.00644
pmid:32793094
pmcid:PMC7385241
fatcat:l3xiy45455dizlwlkg2fyerh6q
Enhanced Flexible Tubular Microelectrode with Conducting Polymer for Multi-Functional Implantable Tissue-Machine Interface
2016
Scientific Reports
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skeletal muscle atrophy. ...
However, if only the electrical interaction existed between electrodes and muscle or nerve tissue without nutrition factor delivery, it would eventually lead to a significant symptom of denervation-induced ...
Acknowledgements The authors thank to partly financial support from the National Natural Science Foundation of China (No. 51475307), 973 Program (2013CB329401), SRFDP (20130073110087). ...
doi:10.1038/srep26910
pmid:27229174
pmcid:PMC4882553
fatcat:w4feso42cbezjpvnp5x4fvr3ly
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