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The Origins of Strain Stiffening in Stiff Biopolymer Networks
2011
Biophysical Journal
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
To reach a site of inflammation, neutrophiles exit blood vessels and migrate through the extracellular matrix (ECM). ...
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
doi:10.1016/j.bpj.2010.12.1870
fatcat:zdpnnuavzjagtgqzo5xxzk5cwq
Spreading Dynamics and Oscillatory Membrane Behavior of B Lymphocytes
2011
Biophysical Journal
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
To reach a site of inflammation, neutrophiles exit blood vessels and migrate through the extracellular matrix (ECM). ...
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
doi:10.1016/j.bpj.2010.12.1872
fatcat:nlbjlpaq7vgbhbbcno2xh3mema
Actin Dynamics and Membrane Topography During T Lymphocyte Spreading
2011
Biophysical Journal
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
To reach a site of inflammation, neutrophiles exit blood vessels and migrate through the extracellular matrix (ECM). ...
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
doi:10.1016/j.bpj.2010.12.1871
fatcat:jumti3bcyjaani6z3w3bxtdgpu
Time-Resolved Observation of Neutrophile Migration Through Three-Dimensional Matrices
2011
Biophysical Journal
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
To reach a site of inflammation, neutrophiles exit blood vessels and migrate through the extracellular matrix (ECM). ...
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
doi:10.1016/j.bpj.2010.12.1869
fatcat:aan4ynhmkngj5jcamt3bngaqsy
Cell Motility on Varying Substrate Stiffness
2011
Biophysical Journal
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
To reach a site of inflammation, neutrophiles exit blood vessels and migrate through the extracellular matrix (ECM). ...
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
doi:10.1016/j.bpj.2010.12.1873
fatcat:3iqzuzm7tje7jf3uquzno5j2rm
Swimming Motility of Monotrichous Pseuomonas Aeruginosa
2011
Biophysical Journal
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
To reach a site of inflammation, neutrophiles exit blood vessels and migrate through the extracellular matrix (ECM). ...
We have studied the spreading dynamics of mouse A20 B cells on antibody coated substrates as a model for B cell activated spreading. ...
doi:10.1016/j.bpj.2010.12.1874
fatcat:dh6wiz3dhvgkjgcvtinxf6tk5i
Dynamic modeling of cancer cell migration in an extracellular matrix fiber network
2017
2017 American Control Conference (ACC)
We have established a dynamic modeling framework for predicting spatiotemporal behaviors of cancer cell migration in the extracellular matrix (ECM). ...
The dynamic model presented in this work suggests the mechanical interplay between filopodia of cancer cell and surrounding viscoelastic ECM fiber network. ...
This material is based upon work supported by the National Science Foundation (NSF), Science and Technology Center (STC) on Emergent Behaviors in Integrated Cellular Systems (EBICS) under Grant CBET-0939511 ...
doi:10.23919/acc.2017.7963047
dblp:conf/amcc/KimAKA17
fatcat:tafwlstxazehtfi6wnqjofltra
Mapping Adhesion Turnover in Migrating Cells: An Image Cross-Correlation Study
2010
Biophysical Journal
Cell adhesion between extracellular matrix and integrin is one of essential structure for cell growth, differentiation and cell motility. ...
From that data we can know the actual force exerted on the particle. The minimum force sensitivity of the system is 80 fN. ...
Cytoskeletal dynamics in single cells have been measured during migration on substrates of varying elastic modulus, but live-cell measurement of structural dynamics during substrate stretch in confluent ...
doi:10.1016/j.bpj.2009.12.3994
fatcat:3kqig6ativggrplpbqpo7pv7gy
Influence of Substrate Stiffness and Thickness on Cell Traction Forces
2014
Biophysical Journal
Circadian rhythms, heart rhythms, neuronal oscillations, cell cycle, and cytoskeletal structures such as the axonemes of cilia are all examples of systems exhibiting oscillatory dynamics. ...
The model also predicts an inverse relationship of maximum contractile force and oscillation period. ...
In the models for cell and substrate mechanics we assume that the cell is an active hypoelastic material and the substrate is linearly elastic. ...
doi:10.1016/j.bpj.2013.11.985
fatcat:6f55tbijkfdshf7wez4jvqykfe
Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics
2021
Frontiers in Cell and Developmental Biology
Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are often assumed to respond elastically for simplicity; the viscoelastic response is quite commonly ignored. ...
The interference of cells with their local microenvironment and the interaction among different cell types relies both on the mechanical phenotype of each involved element. ...
matrices, is that stress relaxation of an extracellular matrix can modify the dynamics of adhesion. ...
doi:10.3389/fcell.2021.785138
pmid:34950661
pmcid:PMC8691700
fatcat:u7aktb5ambbahij4reg4fnlgfm
A guide to mechanobiology: Where biology and physics meet
2015
BBA - Molecular Cell Research
Here we provide an introductory overview of the key players important to cellular mechanobiology, taking a biophysical perspective and focusing on a comparison between flat versus three dimensional substrates ...
Moreover, matrix mechanics can be exploited to program stem cell differentiation for organ-on-chip and regenerative medicine applications. ...
This interpretation is supported by a study of substrate-dependent stress fiber alignment [60] and a model representing the cell as a prestrained elastic disk attached to an elastic substrate via molecular ...
doi:10.1016/j.bbamcr.2015.05.007
pmid:25997671
fatcat:yruttmylczgczk64rcpaqq6k4i
A Cellular Potts model simulating cell migration on and in matrix environments
2012
Mathematical Biosciences and Engineering
How does a cell migrate then on an in ECMs? ...
A Cellular Potts Model simulating cell migration on and in matrix environments. 2000 Mathematics Subject Classification. ...
In the CPM model, we simulate the effect of varying substrate fiber density on cell migration in 3D networks, where matrix fiber form a regular cubic mesh, with uniform pore sizes that decrease due to ...
doi:10.3934/mbe.2013.10.235
pmid:23311371
fatcat:qzfsrirupzf2dfdqzirguqicpy
Multiscale mechanobiology: computational models for integrating molecules to multicellular systems
2015
Integrative Biology
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Biographies ...
of forces can be more effective in an elastic network than a viscoelastic one because the viscous aspect of the networks dissipates energy. ...
Additionally, the glycocalyx was modeled as an elastic buffer between the cell and the ECM. ...
doi:10.1039/c5ib00043b
pmid:26019013
pmcid:PMC4677065
fatcat:pcav35gji5emlgto32avf7l5fq
Computational modeling of three-dimensional ECM-rigidity sensing to guide directed cell migration
2018
Proceedings of the National Academy of Sciences of the United States of America
its movement (23), a 3D finite-element model of cell migration by extending pseudopodia as sensors on a 2D substrate (24), and a hybrid cellular Potts and finite-element computational model of collective ...
A migrating cell probes the stiffness of ECM through filopodia interactions with the surrounding 3D network of ECM fibers. ...
A recent interesting study has shown that collective cell migration on the elastic substrate more preferentially directs toward stiffer substrate than single-cell migration on the identical substrate, ...
doi:10.1073/pnas.1717230115
pmid:29295934
pmcid:PMC5776995
fatcat:7e3gxxfmuncl5jmb3kqebutwz4
The Role of Entropy and Enthalpy of Actin Filaments in Cellular Actin-Based Processes: Two Examples
2013
Biophysical Journal
As stretch is applied to a model of the actin filament network, the distribution of bond angles in the network transitions from a more peaked to a flatter distribution. ...
We used our approach to explore various thresholding models of how actin filament network deformations might influence rates of release of bound signaling molecules. ...
Focal adhesions connecting the cell and the substrate are modeled as a collection of discrete elastic springs. ...
doi:10.1016/j.bpj.2012.11.1762
fatcat:l4zsp2jgnzdmnbr3vgyjieswqm
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