Distributed Denial of Service (DDoS) attacks pose a threat in constant growth. This paper addresses their mitiga- tion by introducing a novel Artificial Immune Systems (AIS) supported by new generation technologies. The approach is based on building networks of distributed sensors suited to the requirements of the monitored environment. These components are capable of identify threats and react according to the be- havior of the biological defense mechanisms in human beings. It is accomplished

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... y emulating the different immune reactions, the establishment of quarantine areas and the construction of immune memory. Experiments performed to date show promising results.