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Portable Analytical Techniques for Monitoring Volatile Organic Chemicals in Biomanufacturing Processes: Recent Advances and Limitations
2020
Frontiers in Chemistry
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major analytical tools in biomanufacturing applications. ...
components, products or potential contaminants in different biomanufacturing processes. ...
Moreover, those methods sometimes are not reliable as it could be difficult to observe subtle differences in case an in-line bioreactor control system is used to adjust deviations in oxygen or pH. ...
doi:10.3389/fchem.2020.00837
pmid:33024746
pmcid:PMC7516303
fatcat:b5heh6ok4vbx5llzcsjdwjezaq
Cyberbiosecurity in Advanced Manufacturing Models
2019
Frontiers in Bioengineering and Biotechnology
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Here, we highlight vulnerabilities in present and future biomanufacturing paradigms given the dependence of this industry sector on proprietary intellectual property, cyber-physical systems, and government-regulated ...
Specifically, we (1) present an analysis of digital information flow in a typical biopharmaceutical manufacturing value chain; (2) consider the potential cyberbiosecurity risks that might emerge from advanced ...
They may display and integrate data from PLCs, hold plans or models, perform calculations, and allow supervisory control via input from plant workers. ...
doi:10.3389/fbioe.2019.00210
pmid:31552236
pmcid:PMC6737271
fatcat:uk5vxfmbsnb5bjkaueziwintdu
Cyberbiosecurity for Biopharmaceutical Products
2019
Frontiers in Bioengineering and Biotechnology
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Advances in technology and manufacturing are increasing the relevance of cyberbiosecurity to the biopharmaceutical manufacturing community in the United States. ...
Cyberbiosecurity is an emerging discipline that addresses the unique vulnerabilities and threats that occur at the intersection of cyberspace and biotechnology. ...
An undetected cyberbiosecurity failure could manifest in, for example, incorrect test results or expiry dates, incorrect process control loops and algorithms, inappropriate conduct of maintenance in the ...
doi:10.3389/fbioe.2019.00116
pmid:31214582
pmcid:PMC6554447
fatcat:wh2pw7h3pjfelmh65s6wnohf6i
Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes
2020
Journal of Industrial Microbiology & Biotechnology
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Therefore, in this work, we both summarize the advances that have been made to date with regards to the monitoring and control of bioprocesses, and highlight some of the key technologies that have the ...
but also by introducing more advanced monitoring and control strategies. ...
and/or new plants). ...
doi:10.1007/s10295-020-02308-1
pmid:32895764
fatcat:qxeqomx7u5bkdbcxcfhintjwtq
The Biomanufacturing of Biotechnology Products
[chapter]
2014
Biotechnology Entrepreneurship
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For this reason, disposable bioreactors runs are able to be scheduled closer together allowing for an increase in plant production. ...
Another factor that can affect the stability of an oxidizable drug in solution is the pH of the formulation buffer. Each drug must be maintained in solution at the pH most favorable to its stability. ...
doi:10.1016/b978-0-12-404730-3.00026-9
fatcat:lacrctmcw5alligk7elszdag3u
Bioprocess Control: Current Progress and Future Perspectives
2021
Life
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This article aims to offer an overview of the current best practices in bioprocess control, monitoring, and automation. ...
This article presents a review of modern control strategies employed in bioprocessing. ...
In DO stat control, concentration of dissolved oxygen is maintained constant whereas in pH stat control, the pH is maintained constant. ...
doi:10.3390/life11060557
fatcat:dwre7wmd65h3pdsew7zgwk26um
Towards Digitalization in Bio-Manufacturing Operations: A Survey on Application of Big Data and Digital Twin Concepts in Denmark
2021
Frontiers in Chemical Engineering
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In this manuscript, a targeted survey was conducted amongst individuals from the Danish biotech industry to understand the current state and perceived future obstacles in implementing digitalization concepts ...
Digitalization in the form of Big Data and Digital Twin inspired applications are hot topics in today's bio-manufacturing organizations. ...
The authors also wish to acknowledge the individuals in the Danish Biotech industry who took the time and effort to answer the survey. ...
doi:10.3389/fceng.2021.727152
fatcat:lgacuw6j3fbexbsy4ttrb7g2su
Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes
2022
Processes
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Sensors were historically used in order to maintain an optimal environment within the reactor to optimize process performance. ...
In this paper, the state-of-the-art sensing technologies and their applications in the context of cell culture monitoring are reviewed with emphasis on the coming push towards industry 4.0 and smart manufacturing ...
Given that low pH by itself does not have the same impact on cell metabolism, CO 2 is an important parameter to control on its own and not only in conjunction with pH. ...
doi:10.3390/pr10020189
fatcat:cp3zlq3ocfdw5mmnkactz4jq2m
A Common Framework for Integrated and Continuous Biomanufacturing
2021
Biotechnology and Bioengineering
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There is a growing application of integrated and continuous bioprocessing (ICB) for manufacturing recombinant protein therapeutics produced from mammalian cells. ...
The framework is capable of supporting the manufacturing of most major biopharmaceutical ICB and legacy processes without major changes in the regulatory license. ...
ACKNOWLEDGMENTS The authors wish to thank the many participants who participated in the discussions and interviews. ...
doi:10.1002/bit.27690
pmid:33491769
fatcat:kxkoulqhxzaytlhhs55tdm5kou
Pilot Production of SARS-CoV-2 Related Proteins in Plants: A Proof of Concept for Rapid Repurposing of Indoor Farms Into Biomanufacturing Facilities
2020
Frontiers in Plant Science
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In this work, we explore how, in a context of rapid exchange of scientific information, plant biofactories can serve as a rapid and easily adaptable solution for local manufacturing of bioreagents, more ...
For this purpose, we tested our ability to produce, in the framework of an academic lab and in a matter of weeks, milligram amounts of six different recombinant monoclonal antibodies against SARS-CoV-2 ...
N. benthamiana-made SARS-CoV-2 Antigens and Antibodies Frontiers in Plant Science | www.frontiersin.org ...
doi:10.3389/fpls.2020.612781
pmid:33424908
pmcid:PMC7785703
fatcat:hgiw3bzknfdf7mjejmlhfljn3i
Engineered biosynthesis of plant polyketides by type III polyketide synthases in microorganisms
2022
Frontiers in Bioengineering and Biotechnology
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A large family of plant specialized metabolites, namely plant polyketides, exhibit diverse and remarkable pharmaceutical properties and thereby great biomanufacturing potential. ...
Plant specialized metabolites occupy unique therapeutic niches in human medicine. ...
Acknowledgments We thank Yinan Wu for the valuable feedback in the preparation of the manuscript. ...
doi:10.3389/fbioe.2022.1017190
pmid:36312548
pmcid:PMC9614166
fatcat:p24gtmpggbctzj5quat2h3hwqu
Theoretical design of a space bioprocessing system to produce recombinant proteins
[article]
2022
bioRxiv
pre-print
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Three designs that differed in biomass dewatering and protein purification approaches had nearly equivalent ESM of 357-522 kg eq. ...
Space-based biomanufacturing has the potential to improve the sustainability of deep space exploration. To advance biomanufacturing, bioprocessing systems need to be developed for space applications. ...
It is not subject to copyright under 17 USC We thank Aditya Hindupur for discussions in the initial phase of the study. ...
doi:10.1101/2022.09.20.508767
fatcat:6no33b6pl5a55cc7mjzkzbskp4
Expression of LamB Vaccine Antigen in Wolffia globosa (Duck Weed) Against Fish Vibriosis
2020
Frontiers in Immunology
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Integration and expression of the LamB gene was confirmed by genomic PCR and RT-PCR. Western blot analysis revealed accumulation of the LamB protein in 8 transgenic lines. ...
We amplified LamB gene from virulent Vibrio alginolyticus and it was modified to maximize the protein expression level and translocate the protein to the endoplasmic reticulum (ER) in plants. ...
Lack of an efficient gene transformation protocol for Wolffia has limited the utilization of this valuable plant as a biomanufacturing platform. ...
doi:10.3389/fimmu.2020.01857
pmid:32973766
pmcid:PMC7468452
fatcat:nxyu5mssrndqbkt4qkk7sgdvki
Production of biofuels and biochemicals by in vitro synthetic biosystems: Opportunities and challenges
2015
Biotechnology Advances
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, open process control, broad 36 reaction condition, tolerance to toxic substrates or products, and so on. ...
optimization and scale-up, soon. 45 46 Keywords: biochemicals, biofuels, economic analysis, in vitro synthetic biosystem, in vitro 47 synthetic biology, innovative biomanufacturing, paradigm shift 48 ...
Furthermore, in vitro enzymatic lactate production could be conducted at low pHs 524 where enzymes could tolerate low pHs better than whole cells so to decrease separation cost of525 lactate (Patnaik et ...
doi:10.1016/j.biotechadv.2014.10.009
pmid:25447781
fatcat:np6olfjsajgg3jllsyzh5vtp3u
Affinity Sedimentation and Magnetic Separation With Plant-Made Immunosorbent Nanoparticles for Therapeutic Protein Purification
2022
Frontiers in Bioengineering and Biotechnology
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an optimized processing scheme with reduced complexity and increased purity. ...
To date, studies in this area have focused on proof-of-concept immunosorbent functionality in biosensing and purification contexts. ...
FIGURE 4 | 4 FIGURE 4 | A summary of the plant virus-based immunosorbent nanoparticle (VIN) preparation process improvement conducted in this study. ...
doi:10.3389/fbioe.2022.865481
pmid:35573255
pmcid:PMC9092175
fatcat:2l26tjyz7ndmfbzpki323k7wxu
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