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Application of smart nanostructures in medicine

Jingjing He, Xiaoxue Qi, Yuqing Miao, Hai-Long Wu, Nongyue He, Jun-Jie Zhu
2010 Nanomedicine  
This results in the red-shift of the plasmon absorption due to interparticle plasmon interactions [10] . This method may extend to screening of AChE inhibitors and relevant drug discovery.  ...  The development of new techniques for monitoring enzyme secretion in tissue culture is important for fundamental research, bioengineering, toxicology and drug discovery.  ...  Application of smart nanostructures in medicine Review www.futuremedicine.com  ... 
doi:10.2217/nnm.10.81 pmid:20874025 fatcat:zg45kdrlaven3nmdcevrxzshgu

Medical Nanorobot Architecture Based on Nanobioelectronics

Adriano Cavalcanti, Bijan Shirinzadeh, Robert Freitas, Luiz Kretly
2007 Recent Patents on Nanotechnology  
This provides useful directions for further research and development of medical nanorobotics and suggests a time frame in which nanorobots may be expected to be available for common utilization in therapeutic  ...  This work describes an innovative medical nanorobot architecture based on important discoveries in nanotechnology, integrated circuit patents, and some publications, directly or indirectly related to one  ...  Wood, for their helpful comments. This project was partially supported by the Australian Research Council (ARC).  ... 
doi:10.2174/187221007779814745 pmid:19076015 fatcat:ksodjohfojabpg4kssm7shtqzm

Advances of medical nanorobots for future cancer treatments

Xiangyi Kong, Peng Gao, Jing Wang, Yi Fang, Kuo Chu Hwang
2023 Journal of Hematology & Oncology  
With the progress of nanotechnology, nanobots enable the assembly and deployment of functional molecular/nanosized machines and are increasingly being utilized in cancer diagnosis and therapeutic treatment  ...  In this paper, we review and analyze the recent advancements of nanobots in cancer treatments, with a particular emphasis on their key fundamental features and their applications in drug delivery, tumor  ...  The logic-gated recognition integrated into inducer-functionalized molecular machines enables rapid cancer dissection, in situ trapping and separation, and the safe delivery of precision medicine.  ... 
doi:10.1186/s13045-023-01463-z pmid:37452423 pmcid:PMC10347767 fatcat:a5fofgihfve2voi4xkgiukapka

Nanomanipulation in Biomedical Applications

Chaojian Hou, Dong Sun, Lixin Dong
2021 Current Robotics Reports  
As an enabling technology, nanorobotic manipulation provides the capability to the control of position and orientation of an object.  ...  Purpose of Review Progress in nanorobotics over the past decades has dramatically extended our ability to explore the world down to individual molecules/atoms.  ...  Min Ju Shon et al. developed an MT-based method for precise force-extension measurements in the 100-nm regime that enables in situ correction of the error in DNA extension measurement [65].  ... 
doi:10.1007/s43154-021-00047-4 fatcat:lgapxej5w5fbxdaxku7dg265ri

Nanomedicine: Application of Nanobiotechnology in Medical Practice

K.K. Jain
2008 Medical Principles and Practice  
This article starts with the basics of nanobiotechnology, followed by its applications in molecular diagnostics, nanodiagnostics, and improvements in the discovery, design and delivery of drugs, including  ...  Numerous applications in the pharmaceutical industry such as drug discovery and drug delivery can be covered under the term 'nanobiopharmaceuticals'.  ...  Apart from refinements in molecular diagnostics, an important basis of personalized medicine, nanobiotechnology also helps in the discovery of biomarkers that are crucial for the development of personalized  ... 
doi:10.1159/000112961 pmid:18287791 fatcat:vcyzhniikfcexod273g7dbzo5i

Recent Process in Microrobots: From Propulsion to Swarming for Biomedical Applications

Ruoxuan Wu, Yi Zhu, Xihang Cai, Sichen Wu, Lei Xu, Tingting Yu
2022 Micromachines  
In particular, the locomotion of these micro/nanorobots, as well as the requirement of biocompatibility, transportation efficiency, and controllable motion for applications in the complex human body environment  ...  Inspired by the motion pattern and collective behaviors of the tiny biological motors in nature, various kinds of sophisticated and programmable microrobots are fabricated with the ability for cargo delivery  ...  For example, some bacteria have a molecular motor in their bodies that controls the helical rotation of the flagellum, which actuate the movement of the bacteria.  ... 
doi:10.3390/mi13091473 pmid:36144096 pmcid:PMC9503943 fatcat:rjpd2lhwsfdvnkjqcx2hs3isyq

Nanodiagnostics: A Revolution in Biomedical Nanotechnology

Stanley Moffatt
2016 MOJ Proteomics & Bioinformatics  
The application of nanobiotechnology in molecular diagnostics is termed nanodiagnostics, and it offers new and exciting options for personalized cancer therapy.  ...  The incorporation of nanobiotechnology with molecular diagnostics deploys 'nanoscale probes' for detailed analysis of cell components that exist in nanoscale dimensions.  ...  Nanoparticles in the discovery of biomarkers Biomedical nanotechnology can replace the current molecular diagnostic technologies for the detection of biomarkers.  ... 
doi:10.15406/mojpb.2016.03.00080 fatcat:lv2qdlmd7zfpnjxhhexfv6bosy

Overview of DNA Self-Assembling: Progresses in Biomedical Applications

Andreia Jorge, Ramon Eritja
2018 Pharmaceutics  
Molecular self-assembling is ubiquitous in nature providing structural and functional machinery for the cells.  ...  Herein, we summarize the recent advances made in the designing of DNA nanostructures with special emphasis on their application in biomedical research as imaging and diagnostic platforms, drug, gene, and  ...  The dynamic nature of 'sense-and-treat' device plays a major role in the construction of a sensitive and robust molecular sensing while inducing specific cell death.  ... 
doi:10.3390/pharmaceutics10040268 pmid:30544945 pmcid:PMC6320858 fatcat:mzwybyhhxfd6lniwvz5wuj5vaa

Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy

Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemian Esfahani, Jing Hou, Niandong Jiao, Lianqing Liu, Liangliang Chen, Macr D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi
2019 IEEE transactions on nanotechnology  
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry.  ...  Developing an effective and efficient method for screening small molecules or compounds is critical to accelerate the discovery of ligands for enzymes, receptors and other pharmaceutical targets.  ...  Li for his help in experimental techniques. The authors would like to thank Dr. J. Yu for her help on arranging the experiments.  ... 
doi:10.1109/tnano.2019.2915507 pmid:32051682 pmcid:PMC7015265 fatcat:ddtr2k5xjzajtb3ujma76bolge

Medicine Soaring with Nanofever

Ridhi Chawla, Shetty KS, Goyal M, Rathore APS, Sharma A
2018 Journal of Nanosciences Current Research  
Sumrrita Saroch for their selfless support throughout.  ...  radio control which can enable targeted drug release in human bloodstream [24] .  ...  Nanorobots Design of nanorobots It is derived from biological models typically, 650 nm in length and 160 nm in diameter.  ... 
doi:10.4172/2572-0813.1000120 fatcat:vewvcywi6nh2vnnnp5tshbl6bu

Applications of Nanobiotechnology in Clinical Diagnostics

K. K. Jain
2007 Clinical Chemistry  
Safety studies are needed for in vivo use.  ...  Results: Nanotechnologies enable diagnosis at the single-cell and molecule levels, and some can be incorporated in current molecular diagnostic methods, such as biochips.  ...  Sensing in picoliter to attoliter volumes might create new problems in the development of microreactors for sensing and novel phenomena in very small channels.  ... 
doi:10.1373/clinchem.2007.090795 pmid:17890442 fatcat:4iop37xqong4nbyximev6y7xli

Synthetic biology devices for in vitro and in vivo diagnostics

Shimyn Slomovic, Keith Pardee, James J. Collins
2015 Proceedings of the National Academy of Sciences of the United States of America  
Synthetic biology devices, such as engineered gene circuits, bring new capabilities to molecular diagnostics, expanding the molecular detection palette, creating dynamic sensors, and untethering reactions  ...  There is a growing need to enhance our capabilities in medical and environmental diagnostics.  ...  Although there is great potential for such tools, the in vivo susceptibility of DNA-based nanorobots to degradation must be addressed before use in humans; but, encouragingly, nanorobots have been successfully  ... 
doi:10.1073/pnas.1508521112 pmid:26598662 pmcid:PMC4664311 fatcat:f236fhocnzd4lffmtvkoztmwky

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

JingJing Zhang, Tian Lan, Yi Lu
2019 Advanced Healthcare Materials  
of a target analyte, resulting in numerous smart nanoprobes for diverse applications including intracellular imaging, drug delivery, in vivo imaging, and tumor therapy.  ...  Benefiting from the recent progress of molecular engineering strategies, the physicochemical properties of nanomaterials are endowed by the target recognition and catalytic activity of FNAs in the presence  ...  [99] who developed a multiple aptamer/nGO based sensing platform for simultaneous monitoring of ATP and GTP in situ. Recently, Yi et al.  ... 
doi:10.1002/adhm.201801158 pmid:30725526 pmcid:PMC6426685 fatcat:fpz4o7c4wzcr3kxkew6ejvo3ba

DNA-Based Fluorescent Nanoprobe for Cancer Cell Membrane Imaging

Xiaoqiao Wu, Xinjia Shuai, Kunhan Nie, Jing Li, Lin Liu, Lijuan Wang, Chengzhi Huang, Chunmei Li
2024 Molecules  
In addition, DNA nanomaterials can be combined with the cell membrane in a specific manner to enable the real-time imaging of signal molecules on the cell membrane, allowing for the real-time monitoring  ...  First, we present the conditions for imaging DNA nanomaterials in the cell membrane microenvironment, such as the ATP, pH, etc.  ...  [69] designed an i-motif with a hairpin as an acid response element and paired it with a tumor-targeting nucleic acid aptamer for the bispecific imaging and in situ drug release of tumor cells, dubbing  ... 
doi:10.3390/molecules29010267 pmid:38202850 pmcid:PMC10780466 fatcat:3bqzkandsbhotdkd4fjtwtfxri

Nanoscale Architectures for Smart Bio-Interfaces: Advances and Challenges [chapter]

Serban F., Sabine Szunerits, Alina Vasilescu, Wolfgang Knoll
2011 Nanofabrication  
For example, the in situ cell pH sensor was mapped in situ with SERS and gold nanoparticles functionalized with 4-mercapto-benzoic acid.  ...  A selective, in situ detection with OTFTs requires a versatile method for the immobilization of various selective molecular probes within proximity to the active transport channel.  ... 
doi:10.5772/28893 fatcat:lkd3h4ilvvhyhfcpq7dxcdhqli
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