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All-Optical Cochlear Implants
[article]
2020
arXiv
pre-print
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In the present work, we introduce a novel cochlear implant (CI) architecture, namely all-optical CI (AOCI), which directly converts acoustic to optical signals capable of stimulating the cochlear neurons ...
Next, we present a comprehensive system model that incorporates the technical characteristics and constraints of each BB, the transdermal-optical-channel particularities, i.e. optical path-loss and external-implanted ...
It should be highlighted that, modern conventional cochlear implants house up to 22 electrodes. ...
arXiv:2006.11577v1
fatcat:wmimzsy7ujavfotnktds3jcpbu
Behavioral and Electrophysiological Responses Evoked by Chronic Infrared Neural Stimulation of the Cochlea
2013
PLoS ONE
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Spiral ganglion neuron counts and post implantation tissue growth, which was localized at the optical fiber, were similar in chronically stimulated and sham implanted cochleae. ...
We examined a population of cats that were chronically implanted with an optical fiber to stimulate the cochlea with infrared radiation, the first known chronic application of INS. ...
Post-implantation tissue growth occurred around the optical fiber. In all examples but one, the tissue was confined to the site of the implantation, as shown in figure 7 . ...
doi:10.1371/journal.pone.0058189
pmid:23505466
pmcid:PMC3591411
fatcat:fs6bxtune5cg5fortazfxlzmde
Auditory-visual speech perception in normal-hearing and cochlear-implant listeners
2008
Journal of the Acoustical Society of America
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The implant users were able to integrate both congruent and incongruent acoustic and optical cues to derive relatively weak but significant auditory-visual integration. ...
Compared with the actual implant performance, acoustic simulations of the cochlear implant could predict the auditory-only performance but not the auditory-visual integration. ...
All cochlear-implant listeners were native English speakers and were postlingually deafened. All cochlear-implant listeners reported normal or corrected-to-normal vision. 1
B. ...
doi:10.1121/1.2816573
pmid:18177171
pmcid:PMC2662523
fatcat:na3ohibks5bdpghspl5hrimwcq
Case report: De novo pathogenic variant in WFS1 causes Wolfram-like syndrome debuting with congenital bilateral deafness
2022
Frontiers in Genetics
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Due to this diagnosis, a second implant was placed after the optic atrophy onset. ...
implant. ...
No signs of vascular narrowing and/or diabetic retinopathy were detected, all suggestive of optic atrophy. ...
doi:10.3389/fgene.2022.998898
fatcat:irherbeo5rdv3pui5p2szslrrq
Hearing Restoration through Optical Wireless Cochlear Implants
[chapter]
2022
Human Auditory System - Function and Disorders [Working Title]
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In this chapter, we present two novel optical wireless-based cochlear implant architectures: (i) optical wireless cochlear implant (OWCI) and (ii) all-optical cochlear implant (AOCI). ...
Our findings reveal that both the OWCI and the AOCI outperform conventional cochlear implant approaches; thus, they are identified as promising architectures for the next generation of cochlear implants ...
Moreover, the superiority of optical over electrical cell stimulation must be validated in order to justify the research effort toward the all-optical cochlear implant (AOCI) [17] . ...
doi:10.5772/intechopen.104622
fatcat:kbhwgzew7zduvndwtagiccgw74
Optical coherence tomography as a guide for cochlear implant surgery?
2008
Photonic Therapeutics and Diagnostics IV
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Optical coherence tomography as a guide for cochlear implant surgery? ...
To assess the potential use of optical coherence tomography (OCT) in cochlear implant surgery, OCT was applied in human temporal bones before cochleostomy. ...
The optical imaging technique can be applied in contact as well as in a non-contact mode. At the Institute for Biomedical Optics in Lübeck, a variety of applicators have recently been developed. ...
doi:10.1117/12.771446
fatcat:f2smnsotnjb5njfxghi2h37y5q
Mimic Cochlear Implant Surgery-Induced Cochlear Infection Fails to Further Damage Auditory Pathway in Deafened Guinea Pigs
2018
Medical Science Monitor
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Conclusions: Mimic cochlear implant surgery-induced cochlear infection caused no significant damage to the auditory pathway in ototoxic drug-induced deafened guinea pigs. ...
SGN density of deafened animals was significantly lower than that of healthy control animals in all ear turns except the basal turn. ...
Determining density of the SGN and brainstem cochlear nucleus neurons, as well as the average optical density (OD) value of neurofilaments in Rosenthal's canal and modiolus All counts of cells in sections ...
doi:10.12659/msm.911392
pmid:30078839
pmcid:PMC6091166
fatcat:mdvo3n2zqjaztldwsux555xjim
Optical Parameter Variability in Laser Nerve Stimulation: A Study of Pulse Duration, Repetition Rate, and Wavelength
2007
IEEE Transactions on Biomedical Engineering
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The technology of optical stimulation could significantly improve cochlear implants, which are hampered by a lack of spatial selectivity. ...
In addition, repetition rates up to 13 Hz can continually stimulate cochlear spiral ganglion cells for extended periods of time. ...
The use of optical stimulation in the auditory system could be beneficial for cochlear implants. ...
doi:10.1109/tbme.2007.892925
pmid:17554829
pmcid:PMC3471085
fatcat:lrysqutk5vhktno4va7u5sydqa
Assistive Devices for Patients with Auditory Neuropathy: Hearing Aid Use
2013
Seminars in Hearing
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Cochlear implants constitute an effective rehabilitative tool able to restore speech perception in many patients with genetic AN, especially those affected by the isolated form of the disorder. ...
It can be concluded that differences in cochlear implant outcome or hearing aid use in patients with AN are related to the pathophysiological mechanisms underlying alteration of auditory nerve discharge ...
100% by 1 year of cochlear implant use. ...
doi:10.1055/s-0032-1333151
fatcat:sepegfnpjfgknhivbgv3zfrugu
Locus coeruleus activity improves cochlear implant performance
[article]
2021
bioRxiv
pre-print
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Despite extensive studies on how cochlear implants activate the auditory system4,8-12, our understanding of cochlear implant-related neuroplasticity remains limited. ...
Cochlear implants are neuroprosthetic devices that can provide hearing to deaf patients1. ...
We thank Cochlear Ltd. for technical support. We thank the Genotyping Core Laboratory of NYU Langone Health for help with genotyping transgenic rats. ...
doi:10.1101/2021.03.31.437870
fatcat:l65fmvhj5bc3zdnaihetaeuqiu
Mutation of OPA1 gene causes deafness by affecting function of auditory nerve terminals
2009
Brain Research
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We investigated cochlear abnormalities accompanying the hearing loss and the effects of cochlear implantation. ...
We sequenced OPA1 gene and recorded cochlear receptor and neural potentials before cochlear implantation. Genetic analysis identified R445H mutation in OPA1 gene. ...
Since hearing loss may not be R445Hspecific, it is warranted to test clinical and subclinical sign of the hearing loss for the individuals with all patients with optic atrophy and OPA1 mutations. ...
doi:10.1016/j.brainres.2009.08.083
pmid:19733158
fatcat:x5oryd5hzje5piviqp2oqrsxke
Recognizing the journey and celebrating the achievement of cochlear implants
2015
Hearing Research
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Acknowledgment We thank all contributors, reviewers and the editorial staff whose quality of work has made the special issue truly special. ...
(Jeschke and Moser, 2015) and an optical auditory brainstem implant (Hight et al., 2015) . ...
To overcome the intrinsic limitations related to broad electric stimulation, novel optogenetic stimulation has been proposed to demonstrate the proof of principle in developing an optical cochlear implant ...
doi:10.1016/j.heares.2015.02.003
pmid:25819292
fatcat:62zsciewkffwbbwd75ucjswcfa
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve
2020
EMBO Molecular Medicine
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Here, we combined virus-mediated optogenetic manipulation of cochlear spiral ganglion neurons (SGNs) and microsystems engineering to establish acute multi-channel optical cochlear implant (oCI) stimulation ...
Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half a million users, thereby re-connecting deaf patients to the auditory scene surrounding them ...
Thus, optical cochlear implants (oCIs) could increase the frequency resolution of artificial sound encoding (Richter et al, 2011; Hernandez et al, 2014) . ...
doi:10.15252/emmm.202012387
pmid:32596983
fatcat:j5fe6emirzfnblulmy5eevjqla
Long-Term Results of the Cochlear Implant in Patients with Otosclerosis
2017
Journal of Otolaryngology-ENT Research
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Materials and methods: Compare cochlear implant results in otosclerosis patient to those to matched pair control group within five years with cochlear implant program -Comfort and Threshold, speech test ...
Otosclerosis is a bone dysplasia of the optic capsule that promotes progressive metabolic derangement, and can lead to profound hearing loss. ...
All the implants used were Cochlear® multichannel implants,
being Nucleus 24k, Nucleus 24M and Nucleus Contour. All of
them have an ACE-type processing strategy.
v. ...
doi:10.15406/joentr.2017.09.00297
fatcat:mak6tvl6ibd5tmpt4owr63xt3q
Optical stimulation of neural tissue
2020
Healthcare technology letters
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Electrical stimulation has been used for decades in devices such as pacemakers, cochlear implants and more recently for deep brain and retinal stimulation and electroceutical treatment of disease. ...
Alternative methods of neural stimulation such as optical stimulation offer the potential to deliver higher spatial resolution of neural activation. ...
For all implanted devices such as retinal prostheses or cochlear implants, the surgery needs to avoid damage to residual function. ...
doi:10.1049/htl.2019.0114
pmid:32754339
pmcid:PMC7353819
fatcat:g6fqpi5ihvgnnf3q7dpgzckvra
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