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Unsupervised Dense Nuclei Detection and Segmentation with Prior Self-activation Map For Histology Images [article]

Pingyi Chen, Chenglu Zhu, Zhongyi Shui, Jiatong Cai, Sunyi Zheng, Shichuan Zhang, Lin Yang
2022 arXiv   pre-print
To this end, we propose a self-supervised learning based approach with a Prior Self-activation Module (PSM) that generates self-activation maps from the input images to avoid labeling costs and further  ...  Furthermore, a two-stage training module, consisting of a nuclei detection network and a nuclei segmentation network, is adopted to achieve the final segmentation.  ...  Conclusion In this paper, we proposed a self-activation map based framework for unsupervised nuclei detection and segmentation.  ... 
arXiv:2210.07862v1 fatcat:z7iftuii6rcrvcdfos233y433a

Unsupervised Data-Driven Nuclei Segmentation For Histology Images [article]

Vasileios Magoulianitis, Peida Han, Yijing Yang, C.-C. Jay Kuo
2021 arXiv   pre-print
An unsupervised data-driven nuclei segmentation method for histology images, called CBM, is proposed in this work.  ...  priors with morphological processing.  ...  CONCLUSION AND FUTURE WORK Nuclei segmentation in histology images is a demanding and prone to errors task for physicians, and its automation is of high importance for cancer assessment.  ... 
arXiv:2110.07147v1 fatcat:dqljx2wiurfohlbu7x3heg42pq

Sparse Autoencoder for Unsupervised Nucleus Detection and Representation in Histopathology Images [article]

Le Hou, Vu Nguyen, Dimitris Samaras, Tahsin M. Kurc, Yi Gao, Tianhao Zhao, Joel H. Saltz
2017 arXiv   pre-print
Our CAE detects and encodes nuclei in image patches in tissue images into sparse feature maps that encode both the location and appearance of nuclei.  ...  In this work, we propose a sparse Convolutional Autoencoder (CAE) for fully unsupervised, simultaneous nucleus detection and feature extraction in histopathology tissue images.  ...  We propose a CAE architecture with crosswise sparsity that can detect and represent nuclei in histopathology images with the following advantages: • As far as we know, this is the first unsupervised detection  ... 
arXiv:1704.00406v2 fatcat:lp3yfks4fndm7dku62qvh5sale

Nuclei Glands Instance Segmentation in Histology Images: A Narrative Review [article]

Esha Sadia Nasir, Arshi Perviaz, Muhammad Moazam Fraz
2022 arXiv   pre-print
Instance segmentation of nuclei and glands in the histology images is an important step in computational pathology workflow for cancer diagnosis, treatment planning and survival analysis.  ...  To the best of our knowledge, no previous work has reviewed the instance segmentation in histology images focusing towards this direction.  ...  In this technique initial learnable layers, learns from prior information (generated edge map through raw input image and predefined shapes) via fixed processing and performs nuclei detection consistent  ... 
arXiv:2208.12460v1 fatcat:drl5p5cxtbadpcpjzoboxdxgnm

Deep neural network models for computational histopathology: A survey [article]

Chetan L. Srinidhi, Ozan Ciga, Anne L. Martel
2019 arXiv   pre-print
Recently, deep learning has become the mainstream methodological choice for analyzing and interpreting cancer histology images.  ...  Finally, we summarize several existing open datasets and highlight critical challenges and limitations with current deep learning approaches, along with possible avenues for future research.  ...  , unsupervised and transfer learning) for a wide variety of histology tasks (e.g., cell or nuclei segmentation, tissue classification, tumour detection, disease prediction and prognosis), and has been  ... 
arXiv:1912.12378v1 fatcat:xdfkzzwzb5alhjfhffqpcurb2u

Synthetic Privileged Information Enhances Medical Image Representation Learning [article]

Lucas Farndale, Chris Walsh, Robert Insall, Ke Yuan
2024 arXiv   pre-print
Multimodal self-supervised representation learning has consistently proven to be a highly effective method in medical image analysis, offering strong task performance and producing biologically informed  ...  In contrast, image generation methods can work well on very small datasets, and can find mappings between unpaired datasets, meaning an effectively unlimited amount of paired synthetic data can be generated  ...  Edwards and the Glasgow Tissue Research Facility.  ... 
arXiv:2403.05220v1 fatcat:yrnm4q2xgrac3mnv7jx4hvmbke

A Tetrahedron-Based Heat Flux Signature for Cortical Thickness Morphometry Analysis [chapter]

Yonghui Fan, Gang Wang, Natasha Lepore, Yalin Wang
2018 Lecture Notes in Computer Science  
Generative Modeling and Inverse Imaging of Cardiac Transmembrane Potential 427 Deep Active Self-paced Learning for Accurate Pulmonary Nodule Segmentation 428 Deep Attentional Features for Prostate Segmentation  ...  of regional brain activity for resting-state fMRI: d-ALFF, d-fALFF and d-ReHo 765 Enhancing clinical MRI Perfusion maps with data-driven maps of complementary nature for lesion outcome prediction 768 Accurate  ... 
doi:10.1007/978-3-030-00931-1_48 pmid:30338317 pmcid:PMC6191198 fatcat:dqhvpm5xzrdqhglrfftig3qejq

Deep Learning Models for Digital Pathology [article]

Aïcha BenTaieb, Ghassan Hamarneh
2019 arXiv   pre-print
the predictive modeling of histopathology images from a detection, stain normalization, segmentation, and tissue classification perspective.  ...  However digitized histopathology tissue slides are unique in a variety of ways and come with their own set of computational challenges.  ...  Another motivation for detecting and segmenting histologic primitives arises from the need for counting of objects, generally cells or nuclei.  ... 
arXiv:1910.12329v2 fatcat:2b7h7i2zwbautewneabghm3bzi

Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions [article]

Luyang Luo, Xi Wang, Yi Lin, Xiaoqi Ma, Andong Tan, Ronald Chan, Varut Vardhanabhuti, Winnie CW Chu, Kwang-Ting Cheng, Hao Chen
2024 arXiv   pre-print
Drawn from the findings of this survey, we present a comprehensive discussion of the challenges and potential avenues for future research in deep learning-based breast cancer imaging.  ...  The major deep learning methods and applications on imaging-based screening, diagnosis, treatment response prediction, and prognosis are elaborated and discussed.  ...  by leveraging the prior knowledge of nuclei size and quantity for nuclei segmentation. [230] SE Weakly supervised cell segmentation by generating reliable pseudo labels from scribbles. [504] SE Self-supervised  ... 
arXiv:2304.06662v4 fatcat:t5nvpybawjhfhiw4h2bekozo74

Study of Computerized Segmentation & Classification Techniques: An Application to Histopathological Imaginary

Pranshu Saxena, Anjali Goyal
2019 Informatica (Ljubljana, Tiskana izd.)  
The main goal of this study is to understand and address the challenges associated with the development of image analysis techniques for computer-aided interpretation of histopathology imagery.  ...  This paper reviews recent state of the art technology for histopathology and briefly describes the recent development in histology and its application towards quantifying the perceptive issue in the domain  ...  Another motivation for detecting and segmenting histological structures has to do with the need for counting of objects, generally cells or cell nuclei.  ... 
doi:10.31449/inf.v43i4.2142 fatcat:wkqlu2h6fjcuxckqltjrtpkgai

Deep Learning in Image Cytometry: A Review

Anindya Gupta, Philip J. Harrison, Håkan Wieslander, Nicolas Pielawski, Kimmo Kartasalo, Gabriele Partel, Leslie Solorzano, Amit Suveer, Anna H. Klemm, Ola Spjuth, Ida‐Maria Sintorn, Carolina Wählby
2018 Cytometry Part A  
for extracting information from image data.  ...  In this review, we focus on deep learning and how it is applied to microscopy image data of cells and tissue samples.  ...  Ewert Bengtsson, and Petter Ranefall for their appreciative suggestions. LITERATURE CITED  ... 
doi:10.1002/cyto.a.23701 pmid:30565841 pmcid:PMC6590257 fatcat:dszbcsfncrhxnazsxopjkbe3ju

Discriminative Pattern Mining for Breast Cancer Histopathology Image Classification via Fully Convolutional Autoencoder [article]

Xingyu Li, Marko Radulovic, Ksenija Kanjer, Konstantinos N. Plataniotis
2019 arXiv   pre-print
With minimum annotation information, the proposed method mines contrast patterns between normal and malignant images in unsupervised manner and generates a probability map of abnormalities to verify its  ...  In this paper, we propose a practical and self-interpretable invasive cancer diagnosis solution.  ...  Second, the proposed method detects discriminative patterns in images in unsupervised manner.  ... 
arXiv:1902.08670v2 fatcat:7jtvmweob5d2jihwsin7bv4sqy

Scale dependant layer for self-supervised nuclei encoding [article]

Peter Naylor, Yao-Hung Hubert Tsai, Marick Laé, Makoto Yamada
2022 arXiv   pre-print
In addition, we extend the existing TNBC dataset to incorporate nuclei class annotation in order to enrich and publicly release a small sample setting dataset for nuclei segmentation and classification  ...  In the present paper, the focus lays in the nuclei in histopathology images. In particular we aim at extracting cellular information in an unsupervised manner for a downstream task.  ...  Thomas Walter for his support in the project and in particular for the insightful discussions, help with the annotations and use of the software.  ... 
arXiv:2207.10950v1 fatcat:f7rnlcb7svc2picorkm3klv7pu

A Survey on Graph-Based Deep Learning for Computational Histopathology [article]

David Ahmedt-Aristizabal, Mohammad Ali Armin, Simon Denman, Clinton Fookes, Lars Petersson
2021 arXiv   pre-print
With the remarkable success of representation learning for prediction problems, we have witnessed a rapid expansion of the use of machine learning and deep learning for the analysis of digital pathology  ...  and biopsy image patches.  ...  The authors segmented the nuclei and construct a cell-graph for each image with nuclei as the nodes, and the distance between neighboring nuclei as the edges, as illustrated in Fig. 6 .  ... 
arXiv:2107.00272v2 fatcat:3eskkeref5ccniqsjgo3hqv2sa

Robust Nucleus/Cell Detection and Segmentation in Digital Pathology and Microscopy Images: A Comprehensive Review

Fuyong Xing, Lin Yang
2016 IEEE Reviews in Biomedical Engineering  
In addition, we discuss the challenges for the current methods and the potential future work of nucleus/cell detection and segmentation.  ...  Digital pathology and microscopy image analysis is widely used for comprehensive studies of cell morphology or tissue structure.  ...  Another learning based method with shape prior modeling is presented in [40] for Pap smear nuclei segmentation, which combines the physical deformable model [255] and the active shape model (ASM)  ... 
doi:10.1109/rbme.2016.2515127 pmid:26742143 pmcid:PMC5233461 fatcat:hx5ldvsppvgzxk6rdiok7siyvi
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