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Stress, noradrenaline, and realistic prediction of mouse behaviour using reinforcement learning
2008
Neural Information Processing Systems
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Reinforcement learning (RL) models have been successful in modeling animal (and human) behaviour, but their success has been limited because of uncertainty as to how to set meta-parameters (such as learning ...
manipulations, can successfully predict mouse behaviour in the "hole-box" -a simple conditioning task. ...
Modeling the hole-box using reinforcement learning We used a simple temporal difference RL model to formalize the behaviour. ...
dblp:conf/nips/LuksysSG08
fatcat:vralwq36pbbbzlraszgq2zzogq
Experimental methods for evaluation of psychotropic agents in rodents: II-Antidepressants
1999
Indian journal of experimental biology
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Rodent models of clinical depression are extensively used for the evaluation of putative antidepressants. ...
These methods have been critically validated in terms of efficacy of standard antidepressants in these tests and, in some cases, by the neurochemical basis of depression, namely, the deficient monoaminergic ...
Unfortunately, none of the existing models perform well against all three sets of validating criteria, including the widely used Porsoll's, learned help-lessness and chronic stress tests. ...
pmid:10641129
fatcat:qvaholj7bbc5rlf4cpxevjnabm
A translational research framework for enhanced validity of mouse models of psychopathological states in depression
2011
Psychoneuroendocrinology
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validity in terms of providing analogue emotional-cognitive endophenotypes and state markers are discussed. (4) The need for aetiological validity of mouse models in terms of G → endophenotypes and E-G ...
tests with (potential) translational value for the quantitative study of these endophenotypes and state markers are presented. (3) The analogous rodent behavioural tests are presented and their translational ...
behaviour controls the stimulus/reinforcement, learned helplessness proposes that subjects learn that their behaviour cannot control the stimulus/reinforcement ( (Seligman et al., 1971 ); see Section ...
doi:10.1016/j.psyneuen.2010.05.003
pmid:20538414
fatcat:7n4mzwmvijha5oo5bkhakbmuda
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and d-amphetamine
2011
Biological chemistry
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use and drug purity. ...
In addition, distinct differences in the metabolism and pharmacokinetics of MDMA between species and different strains of animals prevent the rationalisation of realistic human dose paradigms in animal ...
However, MDMA impairs learning and memory formation in mice and increases phosphorylation of the fibrillary tangle protein TAU in the mouse hippocampus (Busceti et al., 2008) . ...
doi:10.1515/bc.2011.016
pmid:21194370
pmcid:PMC4497800
fatcat:flz4fwmmzvhfjmxf6njkhszzhm
Stratified medicine for mental disorders
2014
European Neuropsychopharmacology
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Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by behaviour and ...
There is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. ...
For example, reinforcement learning theory has highlighted the importance of prediction errors as teaching signals for learning and has related these to phasic firing of midbrain dopamine neurons (Schultz ...
doi:10.1016/j.euroneuro.2013.09.010
pmid:24176673
fatcat:5u4n44l2trcydkcumhauf7l6bu
Basic and Clinical Neuroscience, Volume 4, Number 4, Full Text
2013
Basic and Clinical Neuroscience
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Hashemian and Dr. Modares for their help in this study. The authors declare that they have no conflicts of interest. ...
The authors wish to express their appreciation to Elmira Ghasemi and Nima Heidari for their assistance and support. ...
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space. ...
doaj:400660605da4459c9996785f07c717f7
fatcat:p6tifvk25zg4dbsuiqkrfuxr6m
Evaluating the links between schizophrenia and sleep and circadian rhythm disruption
2012
Journal of neural transmission
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We suggest that these associations can be explored at a mechanistic level by using animal models. Specifically, we predict that SCRD should be observed in schizophreniarelevant mouse models. ...
There is a rapidly accumulating body of evidence which supports this prediction, as summarised in this review. ...
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) ...
doi:10.1007/s00702-012-0817-8
pmid:22569850
fatcat:2debie3ghbc65jf3xtigp5rtgi
Time to re-engage psychiatric drug discovery by strengthening confidence in preclinical psychopharmacology
2021
Psychopharmacology
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collaboration; and (8) learn and reflect. ...
the power of translational and systems neuroscience approaches; (3) use disease-relevant experimental perturbations; (4) identify molecular targets via genomic analysis and patient-derived pluripotent ...
Declarations Conflict of interest TWR discloses consultancy and royalties with Cambridge Cognition and consultancy with Greenfield Bioventures, Takeda, Arcadia, Heptares and Cassava. ...
doi:10.1007/s00213-021-05787-x
pmid:33694032
fatcat:gh4m3mmjlzhirfh3ekenxpddvi
BNA Festival of Neuroscience 2019
2019
Brain and Neuroscience Advances
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An n of 6 will be used for experiments. ...
This study aimed to investigate the effect of stress on brain connectivity in an adolescent population using a graph theory approach. ...
The behavioural dynamics of learning will be described using the duration of behavioural acts and whole behavioural cycles. ...
doi:10.1177/2398212819855490
fatcat:y4b5r7rpdnblzoxvb2crpzqhee
The Gut-Brain Axis, BDNF, NMDA and CNS Disorders
2016
Neurochemical Research
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deficits and these may be useful to supplement the actions of drugs in the treatment of CNS disorders. ...
A reduction of NMDAR input onto GABA inhibitory interneurons causes disinhibition of glutamatergic output which disrupts the central signal-to-noise ratio and leads to aberrant synaptic behaviour and cognitive ...
This not only reinforces the idea that the absence of gut microbiota was the cause of the stress and anxiety behaviour, but also introduces the prospect of using live cultures of healthy bacteria to maintain ...
doi:10.1007/s11064-016-2039-1
pmid:27553784
fatcat:w5b3fiy5lnem5naeqyanuunypu
Compassion as an antidote to cruelty
2006
Behavioral and Brain Sciences
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The resulting cultural elaborations of cruelty in war, in sacrificial rites, and as entertainment are examined to show the historical and cross-cultural stability of the uses of cruelty for punishment, ...
Stage 3 is the emergence of cruelty about 1.5 million years ago as a hominid behavioural repertoire that promoted fitness through the maintenance of personal and social power. ...
ACKNOWLEDGMENT I am grateful to the very many friends and colleagues who have, since 1995, reviewed (and listened to) earlier versions of this article, and to the BBS referees and commentators (in particular ...
doi:10.1017/s0140525x06279056
fatcat:sc6tolblavajtpztacbgr2lqee
ACNP 57th Annual Meeting: Poster Session II
2018
Neuropsychopharmacology
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Results: 6 weeks post AAV8.CRP infection, and subsequent to predator stress and trauma reminder behavioral testing, levels of plasma CRP were almost three-fold higher in animals who had received AAV8.CRP ...
We tested the hypothesis that increased CRP after gene transfer using an adeno-associated virus (AAV8) encoding murine CRP may confer a higher risk for PTSD-like behaviors after predator stress. ...
and deficits in positive reinforcement learning. ...
doi:10.1038/s41386-018-0267-6
fatcat:febeq6uwefgdzm65ccmzrmjwjy
30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts
2021
Journal of Computational Neuroscience
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Recently, the framework of predictive coding (Sajikumar et al., 2014 ...
One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized ...
Acknowledgements This study has been carried out using HSE unique equipment (Reg. num 354,937) and supported by the RF Government grant ag. № 075-15-2021-673. ...
doi:10.1007/s10827-021-00801-9
pmid:34931275
pmcid:PMC8687879
fatcat:evpmmfpaivgpxdqpive5xdgmwu
Orexin and Circadian Influences in Sleep and Psychiatric Disorders: A Review of Experimental and Computational Modelling Studies
[chapter]
2015
Orexin and Sleep
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Our main aim is to understand how these physiological systems interact and how alteration in any of these factors can contribute to the behaviours commonly observed in depressive patients. ...
Due to the complexity and extensive connectedness of neurobiological systems, understanding the biological causes and mechanisms of psychiatric disorders present major research challenges. ...
The model could capture some of the features of mouse the sleep-wake behaviour (such as short-term awakening), and also predicts the mechanism for state transitions. ...
doi:10.1007/978-3-319-23078-8_16
fatcat:xlvi2heopfbyjbmgoxrvvbt45y
ACNP 57th Annual Meeting: Poster Session III
2018
Neuropsychopharmacology
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There is growing evidence that the biological mechanisms of depression significantly overlap with those observed during the aging process, leading to an acceleration of brain and systemic aging in depressed ...
Finally, the dysregulation of senescence-related biological cascades can provide a molecular link between depression and accelerated brain and systemic aging across the lifespan. ...
We thus sought a framework that is more realistic, generalizable, and can help unify computational study of learning. ...
doi:10.1038/s41386-018-0268-5
fatcat:wiooxnisvfhovadauljiso4ie4
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