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Ephrin-A3 Suppresses Wnt Signaling to Control Retinal Stem Cell Potency
2013
Stem Cells
The ciliary epithelium (CE) of adult mammals has been reported to provide a source of retinal stem cells (RSCs) that can give rise to all retinal cell types in vitro. A recent study, however, suggests that CE-derived cells possess properties of pigmented ciliary epithelial cells and display little neurogenic potential. Here we show that the neurogenic potential of CE-derived cells is negatively regulated by ephrin-A3, which is upregulated in the CE of postnatal mice and presents a strong
doi:10.1002/stem.1283
pmid:23165658
pmcid:PMC3572266
fatcat:fnmmhqrrtbd3texbrwj3syk5pq
more »
... tory niche for adult RSCs. Addition of ephrin-A3 inhibits proliferation of CEderived RSCs and increases pigment epithelial cell fate. In contrast, absence of ephrin-A3 promotes proliferation and increases expression of neural progenitor cell markers and photoreceptor progeny. The negative effects of ephrin-A3 on CE-derived RSCs are mediated through activation of an EphA4 receptor and suppression of Wnt3a/β-catenin signaling. Together, our data suggest that CE-derived RSCs contain the intrinsic machinery to generate photoreceptors and other retinal neurons, while the CE of adult mice expresses negative regulators that prohibit the proliferation and neural differentiation of RSCs. Manipulating ephrin and Wnt/β-catenin signaling may, thus, represents a viable approach to activating the endogenous neurogenic potential of CE-derived RSCs for treating photoreceptor damage and retinal degenerative disorders.
Page 577 of None Vol. 117, Issue 3053
[page]
1914
None
Peters, now by Marlow, and now at Chenies or Chalfont St. Giles or Stoke Poges. ...
That whole place is somehow steeped in Shelley as no place in England is and as no place in Italy. ...
Page 276 of Tradesman; Or, Commercial Magazine Vol. 4, Issue 21
[page]
1810
Tradesman; Or, Commercial Magazine
Shelley G. Whiechapel, hower,
Spencer J, Manchester, victuatler.
Stratton G. Piecadilly, ironmonger.
Towne J. Oxford market, careass butcher,
Turpin R. Manchester, dealer.
Ward J. ...
Chenies street, Bedford square, carpenter, Cannon RK, Kingsland road, builder, Chatterton W. Waltham, Lincoln, grocer. Chavbaud Ul. Plumbuee street, Blooms bony. soereian. ;
Chichiey &, P. ...
Page 1418 of The Lancet Vol. 1, Issue 4107
[page]
1902
The Lancet
Communications should be addressed to the secretary of the Dinner Committee at the College, 22, Chenies-street, Gower-street, W.C. ...
Sir Percy Shelley, however, was content to win only social popularity as an organiser of private theatricals. ...
Page 656 of The Gentleman's Magazine Vol. 207, Issue
[page]
1859
The Gentleman's Magazine
At Shelleys, Knockholt, Kent, aged 87, William Marter, esq., H.E.I.C., C.S.
At Ewell, aged 90, Frances, relict of Edward Marter, esq., formerly of Chenies, Bucks. ...
Page 716 of Psychological Abstracts Vol. 29, Issue 5
[page]
1956
Psychological Abstracts
M.. 1361, 7362 | Wu Cheni, 7387” - 6673 Stagner, R., 6830, 7852 Thorpe, J. J., 7458 Wapner ¢: 6700 Wulff, V. J., 6722, 6760 Shanner, W. M., 7775 Stamm, Ps S., 6812 Thrush, R. S., 6849 Ward, J. ...
L.. 4410 Shelley, W. B., 6682 Steinberg, H. 608 Tobias, J. M. 6652, 6674 Wattenberg, . W., 7500, Yonge’ kn A. 160 fe _ A. Hi, *D., | M., 6633 7501 Lm Shepp, B. E., 7876 Stepan, M., 7448 Toch, H. ...
Page 403 of British Medical Journal Vol. , Issue SUPPLEMENT
[page]
1907
British Medical Journal
MEDICAL GRADUATES’ COLLEGE AND POLYCLINIC, 22, Chenies Street, W:C. ...
Shelley, M.A, M.D, M.R.C.P, and E. Stenhouse, B.Sc. Book If. London: Macmillan and Co., Limited. 1907. 1s. 4d.
*. In forvarding- books the publishers are-requssted te state the ing price. ...
Page 229 of Florida Bar Journal Vol. 72, Issue 8
[page]
1998
Florida Bar Journal
7917 11th Ave Brooklyn NY 11226-2625
MACCHI, Leonor Angelica . . .941/947-4453
27^ Riverwak Way Borxta Springs 34134-1675
MACCI, Lisa Mane . 561/361-8528
2255 Glades Rd Boca Ralon 33431-7382
MACCINI, Shelley ...
I, Donald Maximilian . 904/3546310
Spohra Wibia Maxwel Et Al 444 E DuvM St Jacksonvie 32202-2767 E-mail: wmms@aol.com Fax: 904/354-0756
MACINA, Robert Paul . 717/2906855
Lancaster Haalih Aiance 609 N Cheny ...
THE HEREDITY OF POETS
1902
The Lancet
Communications should be addressed to the secretary of the Dinner Committee at the College, 22, Chenies-street, Gower-street, W.C. ...
Sir Percy Shelley, however, was content to win only social popularity as an organiser of private theatricals. ...
doi:10.1016/s0140-6736(01)83854-x
fatcat:3pw7vzabyfcxjnckog25wvga3m
Page 165 of The Solicitors' Journal Vol. 11, Issue
[page]
1866
The Solicitors' Journal
Densham, emptor: a Cayler, Fredk Shelley, Clifton, Bristol, Clerk in Holy Orders. Pet Reg Dec 5. Bristol, Dec 19 at 11. Benson, Bristol. ...
Adams, John, Chenies-mews, Bedford-st, Cab Proprietor. Pet Dec 6. Dec 24 at 1}. Towne, Gt Russell-st, Bloomsbury. Antill, Wm Jas, Euston-rd, Undertaker. Pet Nov 27, Dec 21 at 11. Chidley, Old Jewry. ...
Page 763 of Great Britain. House of Commons. Journal Vol. 75-92, Issue
[page]
1820
Great Britain. House of Commons. Journal
Chenies, 594. 188 of the City of i al xcr. 116. Corporation of Liverpool, 433. Chepstow, 478, p. Chesham, 567. Chester, 520. 527. Chester, to ———-For Reform ; From, Kilcoman and Robin, xcu.29. ...
Clayton and Shelley, ha- Corporation and Test Acts: 520. Clears, Saint, 521, Pp. Cleckheaton, 510. Clifton, 567. nd, 623. Swe, For the Repeal of the Corporation and Test Acts ; Clitheroe, 520. ...
UNIVERSITY COLLEGE, LONDON : APPEAL FOR THE EQUIPMENT AND ENDOWMENT OF ADVANCED UNIVERSITY EDUCATION AND RESEARCH
1902
The Lancet
Sir Percy Shelley, however, was content to win only social popularity as an organiser of private theatricals. ...
The late Sir Percy Shelley should have been a paragon to judge by his ancestry, a poet father and a mother who wrote" Frankenstein." ...
doi:10.1016/s0140-6736(01)83855-1
fatcat:lkzq3vy7nrddfjq22gr2mfm5du
Page 767 of None Vol. 22, Issue 571
[page]
1861
None
He is well represented by several fine examples: ‘* Chenies House, near Bram- bletye, Sussex ” (20), full of quiet truth and refinement; “ Pont Neuf, Paris,” 1821 (22), of which the historical interest ...
interesting as among those first members of the Old Water Colour Society who made a position for the art, and prepared the way for their more gifted successors, of Glover, Hills, Nicholson, Barrett, Havell, Shelley ...
Page 512 of None Vol. 21, Issue 548
[page]
1866
None
Good specimens of Scott, Byron, Wordsw Coleridge, Shelley, Keats, Motherwell, Tennyson, and even Aubrey de Vere, are to be found among the specimens of this century's erotic verse. ...
ourselves tothenseesgeit the volume is, in its mechanical execution, the most elegant me book ever issued, we are free to confess that it is very go Poetry and elaborately got up, with creamy-tinted paper, cheny-celow ...
Page 335 of Florida Bar Journal Vol. 71, Issue 8
[page]
1997
Florida Bar Journal
SLATKIN,Jason Elliot . 94
SLATKIN,Sheldon Theodore . 81
SOMMERER,Diane K . 82
STADLER,Scott Jonas . 94
STAUM,NoraC . 94
STETZER,Claudene Losey . 87
STILL,lra W,lll . 73
STLAURENT,LouisS . 65
STRAYHORN,Cheny ...
Cindy Rainbow . 93
MIDLAM,Dou^ Lee . 86
MILCHMAN,fk)ward Joseph . 87
MILLER,Eric Jay . 91
MITTELBERG,Barry Steven . 84
MONAS,Robert Gary . 80
MONTAIGNE,Elizabeth H . 91
MOORE, Andrea Lobert . 85
MUN0,Shelley ...
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