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Properties of Isostables and Basins of Attraction of Monotone Systems [article]

Aivar Sootla, Alexandre Mauroy
2016 arXiv   pre-print
In this paper, we investigate geometric properties of monotone systems by studying their isostables and basins of attraction.  ...  We discuss computational approaches to estimate isostables and basins of attraction and illustrate the results on two and four state monotone systems.  ...  CONCLUSION In this paper, we study geometric properties of monotone systems such as properties of isostables and basins of attraction.  ... 
arXiv:1510.01153v2 fatcat:zd6nvcvuxrhnjiiaeerjlcuh6m

Geometric Properties of Isostables and Basins of Attraction of Monotone Systems [article]

Aivar Sootla, Alexandre Mauroy
2017 arXiv   pre-print
In this paper, we study geometric properties of basins of attraction of monotone systems. Our results are based on a combination of monotone systems theory and spectral operator theory.  ...  We also show how variations in basins of attraction can be bounded under parametric uncertainty in the vector field of monotone systems.  ...  Geometric Properties of Isostables and Basins of Attraction of Monotone Systems Aivar Sootla and Alexandre Mauroy Abstract-In this paper, we study geometric properties of basins of attraction of monotone  ... 
arXiv:1705.02853v1 fatcat:vfgxfalkcfcdrniv7oxpafuxay

Optimal control formulation of pulse-based control using Koopman operator

Aivar Sootla, Alexandre Mauroy, Damien Ernst
2018 Automatica  
It was recently shown that, for monotone bistable systems, this problem admits easy-to-implement open-loop solutions in terms of temporal pulses (i.e., step functions of fixed length and fixed magnitude  ...  We show that this problem can be solved using a static optimization problem in the case of monotone systems.  ...  Assume now that the system is monotone with two exponentially stable equilibria x * and x • and basins of attraction B(x * ) and B(x • ), respectively.  ... 
doi:10.1016/j.automatica.2018.01.036 fatcat:36avoe4ixfcyzlsrteypdcvmka

Pulse-Based Control Using Koopman Operator Under Parametric Uncertainty

Aivar Sootla, Damien Ernst
2018 IEEE Transactions on Automatic Control  
Furthermore, we indicate how our tools can be used for a class of non-monotone systems, and more importantly how these tools can be extended to other control problems.  ...  In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals.  ...  We finally mention spectral properties of monotone systems ( [13] ).  ... 
doi:10.1109/tac.2017.2736941 fatcat:vmeamib4rnbo5ddgsj7ionn6v4

Pulse-Based Control Using Koopman Operator Under Parametric Uncertainty [article]

Aivar Sootla, Damien Ernst
2017 arXiv   pre-print
Furthermore, we indicate how our tools can be used for a class of non-monotone systems, and more importantly how these tools can be extended to other control problems.  ...  In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals.  ...  We finally mention spectral properties of monotone systems ( [13] ).  ... 
arXiv:1708.00232v1 fatcat:rt4nxltibbdzjg4tudbbppdgim

Shaping Pulses to Control Bistable Monotone Systems Using Koopman Operator

Aivar Sootla, Alexandre Mauroy, Jorge Goncalves
2016 IFAC-PapersOnLine  
The original framework was derived for monotone systems and all the extensions relied on monotone systems theory.  ...  Additionally, we show that for monotone systems the switching function is also monotone in some sense, a property that can yield efficient algorithms to compute it.  ...  Assumptions A1 and A2 guarantee the existence of eigenfunctions s * 1 (x) and s • 1 (x) that are continuously differentiable on each basin of attraction.  ... 
doi:10.1016/j.ifacol.2016.10.247 fatcat:6sfocc62v5ddfofpiwqnfbrxpa

Shaping Pulses to Control Bistable Monotone Systems Using Koopman Operator [article]

Aivar Sootla, Alexandre Mauroy, Jorge Goncalves
2016 arXiv   pre-print
The original framework was derived for monotone systems and all the extensions relied on monotone systems theory.  ...  Additionally, we show that for monotone systems the switching function is also monotone in some sense, a property that can yield efficient algorithms to compute it.  ...  Assumptions A1 and A2 guarantee the existence of eigenfunctions s * 1 (x) and s • 1 (x) that are continuously differentiable on each basin of attraction.  ... 
arXiv:1605.06252v1 fatcat:inhipqirfrgz3fj7kuaoyjmbqq

Operator-Theoretic Characterization of Eventually Monotone Systems [article]

Aivar Sootla, Alexandre Mauroy
2017 arXiv   pre-print
In order to provide a characterization, we drew inspiration from the results for linear systems, where eventually monotone (positive) systems are studied using the spectral properties of the system (i.e  ...  Perron-Frobenius property).  ...  We conclude this subsection by a corollary of Theorem 1, which describes the geometric properties of the system in the basin of attraction.  ... 
arXiv:1510.01149v3 fatcat:jr6wriw7sbftliffy24m7f2xrm

Global computation of phase-amplitude reduction for limit-cycle dynamics

A. Mauroy, I. Mezić
2018 Chaos  
basin of attraction of the limit cycle.  ...  We illustrate the method by computing the so-called isostables of limit cycles in two, three, and four-dimensional state spaces, as well as their responses to strong external inputs.  ...  We note that, in the case of planar systems, this is an exact (non-reduced) representation of the system in the basin of attraction of the limit cycle. C.  ... 
doi:10.1063/1.5030175 pmid:30070491 fatcat:mqfchfnoibfgxnrizvppqodody

An operator-theoretic viewpoint to non-smooth dynamical systems: Koopman analysis of a hybrid pendulum [article]

Nithin Govindarajan, Hassan Arbabi, Louis van Blargian, Timothy Matchen, Emma Tegling, Igor Mezić
2016 arXiv   pre-print
A connection is drawn between these two interpretations of a dynamical system by means of establishing a link between the spectral properties of the Koopman operator and the geometric properties in the  ...  We apply an operator-theoretic viewpoint to a class of non-smooth dynamical systems that are exposed to event-triggered state resets.  ...  Basin of attraction The basin of a specific limit cycle p 1 can be found by repeatedly computing the pre-images of the map (13) .  ... 
arXiv:1608.08734v1 fatcat:a6nommyskbeztcledufejdg2bu

An operator-theoretic approach to differential positivity

A. Mauroy, F. Forni, R. Sepulchre
2015 2015 54th IEEE Conference on Decision and Control (CDC)  
In this paper, we investigate the general connections between the (geometric) properties of differentially positive systems and the (spectral) properties of the Koopman operator.  ...  In particular, we obtain converse results for differential positivity, showing for instance that any hyperbolic limit cycle is differentially positive in its basin of attraction.  ...  is strictly differentially positive in the basin of attraction B(Γ) ⊆ R n of Γ.  ... 
doi:10.1109/cdc.2015.7403327 dblp:conf/cdc/MauroyFS15 fatcat:7pvofe6jpjgu5edv5xmheemveu

An operator-theoretic approach to differential positivity [article]

A. Mauroy, F. Forni, R. Sepulchre
2015 arXiv   pre-print
In this paper, we investigate the general connections between the (geometric) properties of differentially positive systems and the (spectral) properties of the Koopman operator.  ...  In particular, we obtain converse results for differential positivity, showing for instance that any hyperbolic limit cycle is differentially positive in its basin of attraction.  ...  is strictly differentially positive in the basin of attraction B(Γ) ⊆ R n of Γ.  ... 
arXiv:1504.01548v1 fatcat:yngajdzecjdbhfndzziancnuj4

Effects of pH on Proteins: Predictions for Ensemble and Single-Molecule Pulling Experiments

Edward P. O'Brien, Bernard R. Brooks, D. Thirumalai
2011 Journal of the American Chemical Society  
We provide a framework based on the Molecular Transfer Model (MTM) to account for pH effects on the properties of globular proteins.  ...  The phase diagrams of CI2 and protein G as a function of f and pH are dramatically different and reflect the underlying pH-dependent stability changes in the absence of force.  ...  This work was supported in part by grants from the National Science Foundation (NSF; 09-14033) and National Institutes of Health (NIH; GM089685) to D.T. and an NIH Graduate Partnerships Program (GPP) Biophysics  ... 
doi:10.1021/ja206557y pmid:22148729 pmcid:PMC3262061 fatcat:xno5r56wqvcnde7bundzwv7v2y

A geometric approach to Phase Response Curves and its numerical computation through the parameterization method [article]

Gemma Huguet, Alberto Pérez-Cervera, Tere M-Seara
2018 arXiv   pre-print
Moreover, we link the existence properties of this invariant curve as the amplitude of the perturbation is increased with changes in the PRC waveform and with the geometry of isochrons.  ...  The underlying idea relies on the construction of a periodic system whose corresponding stroboscopic map has an invariant curve.  ...  We also acknowledge the use of the UPC Dynamical Systems group's cluster for research computing (https://dynamicalsystems.upc.edu/en/computing/).  ... 
arXiv:1809.07318v1 fatcat:xh236iot2nb2po4opyufdrw5fe

Sequencing of folding events in Go-type proteins

Trinh Xuan Hoang, Marek Cieplak
2000 Journal of Chemical Physics  
The folding scenarios for CI2 and SH3 are consistent with experimental studies of their transition states.  ...  The order of events depends primarily on the geometry of the native state. Variations in temperature, coupling strengths and viscosity affect the sequencing scenarios to a rather small extent.  ...  In Section 3, we discuss ways to delineate the native basin and we determine the folding properties of the models. The mechanisms of folding for each of the proteins are discussed in Section 4.  ... 
doi:10.1063/1.1314868 fatcat:e334k6vpovgq7phb3gi2ae4i3u
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