A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Filters
A Neuron Model with Spatially Distributed Synaptic Input
1971
Biophysical Journal
Preserved Fulltext
The model consists of two terminal electronic analogue circuits with inputs controlled by a LINC computer. One terminal represents the inside of a membrane patch, the other represents the outside. ...
Two circuit designs are used: one simulates spike-generating regions of the neuron, the other simulates subthreshold activity in inexcitable regions. ...
Spikes
Control of Inputs to the Model The inputs to the neuron model are controlled by a computer program. The same program has a provision to compute simultaneously appropriate spike histograms. ...
doi:10.1016/s0006-3495(71)86218-5
pmid:4325425
pmcid:PMC1483967
fatcat:dvptpljatzff3fhdpohjd2mi2u
Learning by the Dendritic Prediction of Somatic Spiking
2014
Neuron
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
We present a simple compartmental neuron model together with a non-Hebbian, biologically plausible learning rule for dendritic synapses where plasticity is modulated by these three factors. ...
Recent modeling of spike-timing-dependent plasticity indicates that plasticity involves as a third factor a local dendritic potential, besides pre-and postsynaptic firing times. ...
Here we present a compartmental neuron model and derive from first principles a plasticity rule in which the voltage modulation of synaptic plasticity has a functional interpretation. ...
doi:10.1016/j.neuron.2013.11.030
pmid:24507189
fatcat:rut3fvbfzjahdod7nlfp2p4t5y
An Increase in AMPA and a Decrease in SK Conductance Increase Burst Firing by Different Mechanisms in a Model of a Dopamine Neuron In Vivo
2006
Journal of Neurophysiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
A stylized, symmetric, compartmental model of a dopamine neuron in vivo shows how rate and pattern can be modulated either concurrently or differentially. ...
If two or more parameters in the model are varied concurrently, the baseline firing rate and the extent of bursting become decorrelated, which provides an explanation for the lack of a tight correlation ...
M E T H O D S
Compartmental model The three-compartment model of Komendantov et al. (2004) was used with a few modifications (see Fig. 1 ). ...
doi:10.1152/jn.00704.2006
pmid:16885519
pmcid:PMC2531289
fatcat:tbrnoyfp3jac5neeojumic7qcq
Computational Analysis of the Impact of Chronic Stress on Intrinsic and Synaptic Excitability in the Hippocampus
2010
Journal of Neurophysiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Here we examine the validity of this framework using biophysical models of hippocampal CA3 pyramidal neurons. ...
Using this algorithm, we build a biophysically realistic computational model to analyze the effects of stress on intrinsic and synaptic excitability. ...
Furthermore, atrophy causes an Modulation of individual currents required for maintaining firing rate and firing pattern homeostasis in a neuron with 35% atrophy. ...
doi:10.1152/jn.00913.2009
pmid:20457854
pmcid:PMC2888238
fatcat:6uryor4zencavfsspizyosl2uq
Direct Current Stimulation Alters Neuronal Input/Output Function
2017
Brain Stimulation
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Results-We show for the first time that DCS modulates the likelihood of neuronal firing for a given and fixed synaptic input. ...
Objective-Test if the neuronal input/output function is affected by DCS Methods-Using rat hippocampal brain slices and computational modeling, we provide evidence for how DCS modulates the neuronal I/O ...
Acknowledgments We greatly acknowledge Gregory Kronberg for helpful discussions and proofreading the manuscripts. ...
doi:10.1016/j.brs.2016.08.014
pmid:27717601
pmcid:PMC5774009
fatcat:dgqda6sus5hiplqvuocbjwl7h4
A modeling based study on the origin and nature of evoked post-synaptic local field potentials in granular layer
2011
Journal of Physiology - Paris
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
In the first, we used a single granule neuron as a model kernel for reconstructing population activity. The second technique consisted using a detailed network model. ...
Understanding population activities of underlying neurons reveal emergent behavior as patterns of information flow in neural circuits. ...
SR/CSI/49/2010 and the Sakshat Project of National Mission on Education through ICT, Department of Higher Education, Ministry of Human Resource Department, Government of India. ...
doi:10.1016/j.jphysparis.2011.07.011
pmid:21843640
fatcat:yg55zftepbc3xl4r5ttc6agwxy
Distinct current modules shape cellular dynamics in model neurons
2016
Neuroscience
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
The methodology also helped reveal that a single core compartment model could capture multiple neuronal properties. ...
for several classes of neurons. ...
So, this neuron had two zones, one below -52.5 mV for the passive module, and one above it for the spiking module. ...
doi:10.1016/j.neuroscience.2016.08.016
pmid:27530698
pmcid:PMC5086448
fatcat:ir2vlclmjvfzxmnf4hoehrxcui
A two-compartment model of synaptic computation and plasticity
2020
Molecular Brain
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Here we present a two-compartment model of the synapse in which the presynaptic terminal first acts to filter presynaptic input before the postsynaptic terminal, acting as a gain controller, amplifies ...
The synapse is typically viewed as a single compartment, which acts as a linear gain controller on incoming input. ...
For instance, consider a pair of neurones for which burst firing in the presynaptic neurone is predictive of the occurrence of a postsynaptic spike. ...
doi:10.1186/s13041-020-00617-1
pmid:32434549
fatcat:agtebhcavbei7klpl33lpqkw3y
Independence of the unimodal tuning of firing rate from theta phase precession in hippocampal place cells
2009
Biological cybernetics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
a reduced CA1 two-compartment neuron model. ...
There are two prominent features for place cells in rat hippocampus. ...
The first author was supported by the Knowledge Innovation Engineering Project of Chinese Academy of Sciences (grant KSCX2-YW-R-39) and National Science Foundation of China (grants 30630028 and 30770495 ...
doi:10.1007/s00422-009-0359-9
pmid:20041262
fatcat:tmigjn35ireubjup7wuxfp3rfa
Multistability in a neuron model with extracellular potassium dynamics
2012
Physical Review E
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
The bifurcation structure and spiking frequency of the two models are studied. ...
We adopt a physiologically relevant hippocampal CA1 neuron model in a zero-calcium condition to better understand the function of extracellular potassium in neuronal seizurelike activities. ...
A particular color denotes a certain type of neuronal firing pattern: green (gray) for a singlet spiking (1s), orange (medium gray) for doublet spiking (2s), and blue (dark gray) for triplet spiking (3s ...
doi:10.1103/physreve.85.061911
pmid:23005131
fatcat:pgxdidmphnf4hiqhtmh5b54c6i
Dendrites: bug or feature?
2003
Current Opinion in Neurobiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
We discuss how dendritic compartments and the interactions between them help to enhance the computational power of the neuron and define the rules for the induction of synaptic plasticity. ...
The integrative properties of dendrites are determined by a complex mixture of factors, including their morphology, the spatio-temporal patterning of synaptic inputs, the balance of excitation and inhibition ...
Acknowledgements We thank the Human Frontier Science Program, the European Union, Wellcome Trust and Gatsby Foundation for support, and Mark Farrant, Mickey London, Troy Margrie, and Arnd Roth for comments ...
doi:10.1016/s0959-4388(03)00075-8
pmid:12850223
fatcat:lvly5l6evfe5pdhaiu4k6wneyy
Modeling Single-Neuron Dynamics and Computations: A Balance of Detail and Abstraction
2006
Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Dendritic inward currents play a major role in the control of spiking (6) or the modulation of responses to synchronous inputs (11) . ...
Level I: Detailed compartmental model of a Purkinje cell.
Fig. 2 . 2 Diversity of neural response patterns. ...
doi:10.1126/science.1127240
pmid:17023649
fatcat:anqfygl275hibbqz3o7vkark2u
Modulatory effects of inhibition on persistent activity in a cortical microcircuit model
2014
Frontiers in Neural Circuits
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
To this end, we constructed a PFC microcircuit, consisting of pyramidal neuron models and all three different interneuron types: fast-spiking (FS), regular-spiking (RS), and irregular-spiking (IS) interneurons ...
the FS model input to the pyramidal neuron models greatly limited the biophysical modulation of persistent activity induction, decreased the ISIs and neuronal synchronicity during persistent activity, ...
MODEL PREDICTIONS AND FUTURE USES Our model generates two important predictions that could be tested experimentally. ...
doi:10.3389/fncir.2014.00007
pmid:24550786
pmcid:PMC3907788
fatcat:gpzxs4ousreyzelbnpdqw6n7b4
Electrical Coupling Between Model Midbrain Dopamine Neurons: Effects on Firing Pattern and Synchrony
2002
Journal of Neurophysiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
We modified a multi-compartment model of DA neuron by adding a spike-generating mechanism and electrically coupling the dendrites of two such neurons through gap junctions. ...
The firing patterns exhibited by the two model neurons included low frequency (2-7 Hz) spiking, high-frequency (13-20 Hz) spiking, irregular spiking, regular bursting, irregular bursting, and leader/follower ...
Model interpretations and predictions This paper presents results using a specific model of a system of two coupled dopamine neurons. ...
doi:10.1152/jn.00255.2001
pmid:11877524
fatcat:ex5ix2boivao3fdawyjzhs57di
Gating of steering signals through phasic modulation of reticulospinal neurons during locomotion
2014
Proceedings of the National Academy of Sciences of the United States of America
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
The neural control of movements in vertebrates is based on a set of modules, like the central pattern generator networks (CPGs) in the spinal cord coordinating locomotion. ...
Sensory feedback is not required for the CPGs to generate the appropriate motor pattern and neither a detailed control from higher brain centers. ...
The large-scale simulations were performed on resources provided by the Swedish National Infrastructure for Computing at the Center for High Performance Computing. ...
doi:10.1073/pnas.1401459111
pmid:24550483
pmcid:PMC3948313
fatcat:3bbhnf2t3jchzcxufvjkmhqyki
« Previous
Showing results 1 — 15 out of 9,535 results