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Technology mapping and retargeting for field-programmable analog arrays
2000
Proceedings of the conference on Design, automation and test in Europe - DATE '00
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Rapid prototyping followed by technology retargeting provides a fast and cost-effective approach to analog system synthesis. ...
Field-programmable analog arrays (FPAAs) enable rapid implementation of a function-compliant prototype, while technology retargeting converts the functional FPAA prototype to an ASIC. ...
Acknowledgments: The authors would like to thank Adrian Nunez, Nagu Dhanwada and Alex Doboli of the VASE team, and special thanks to Satish Ganesan. ...
doi:10.1145/343647.343700
fatcat:fxpp23va5vawhpkhwnh3fqsm2m
System-level design automation tools for digital microfluidic biochips
2005
Proceedings of the 3rd IEEE/ACM/IFIP international conference on Hardware/software codesign and system synthesis - CODES+ISSS '05
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Analogous to classical VLSI synthesis, a top-down system-level design automation approach can shorten the biochip design cycle and reduce human effort. ...
Current full-custom design techniques for digital microfluidic biochips do not scale well for increasing levels of system integration. ...
As in the case of high-level synthesis for integrated circuits, resource binding in the biochip synthesis flow refers to the mapping from bioassay operations to available functional resources. ...
doi:10.1145/1084834.1084887
dblp:conf/codes/ChakrabartyS05
fatcat:swxbvv2wsbfejb2yyrpsfyjbsq
High-level Synthesis
[article]
2019
arXiv
pre-print
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Other Versions
2008
Wiley Encyclopedia of Computer Science and Engineering
unpublished
doi:10.1002/9780470050118.ecse177 fatcat:icesm3tunzecbngbszcfjkvanm
doi:10.1002/9780470050118.ecse177 fatcat:icesm3tunzecbngbszcfjkvanm
The chained synthesis tasks at each level of the design process include system synthesis, register-transfer synthesis, logic synthesis, and circuit synthesis. ...
High-level synthesis (HLS) could be defined as the translation from a behavioral description of the intended hardware circuit into a structural description similar to the compilation of programming languages ...
The chained synthesis tasks at each level of the design process include system synthesis, register-transfer synthesis, logic synthesis, and circuit synthesis. ...
arXiv:1905.02076v1
fatcat:ffzc23yqevauji7hc42lazlila
Discovery and Development of a Potent and Highly Selective Small Molecule Muscarinic Acetylcholine Receptor Subtype I (mAChR 1 or M1) Antagonist In Vitro and In Vivo Probe
2009
Current Topics in Medicinal Chemistry
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An iterative parallel synthesis approach was employed to optimize all three series in parallel, which led to the development of novel microwave-assisted chemistry and provided important take home lessons ...
for probe development projects. ...
Therefore, we quickly explored multiple parameters and developed general, high yielding microwave-assisted protocols to accelerate the synthesis of analogs of HTS lead 6. ...
doi:10.2174/156802609789753635
pmid:19807667
pmcid:PMC4765323
fatcat:m3hiuqvcijbp7cchbauu755fji
Synthetic Compound Libraries Displayed on the Surface of Encoded Bacteriophage
2003
Chemistry and Biology
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Encoded phage serve these libraries are a useful tool for sorting through large pools of synthetic compounds for molecules binding to as extremely robust reporters of the presence of each compound, providing ...
To evaluate this approach, we constructed a library of 980 analogs of folic acid dis-studies of cellular uptake and transport, and for most in vivo applications. played on T7 phage, and demonstrated rapid ...
for attachment of nicotinic acid derivatives. ...
doi:10.1016/j.chembiol.2003.08.005
pmid:14522055
fatcat:affv7xylazeglohszlm5jo2zkq
ADVANCES IN CHEMICAL GENETICS
2005
Annual review of genomics and human genetics (Print)
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■ Abstract Chemical genetics is an emerging approach for studying biological systems using chemical tools. ...
This strategy aims to reveal the macromolecules responsible for regulating biological systems; thus, the approach shares much in common with genetics. ...
Thus, SLIMS provides a framework for analyzing high-throughput assay data both as a laboratory information management system and as a platform for experimental analysis. ...
doi:10.1146/annurev.genom.6.080604.162136
pmid:16124862
fatcat:r26ihyhqijgvtnhduyudkigkuu
Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing
2011
Bioorganic & Medicinal Chemistry
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This study reports the design and synthesis of two libraries of new, non-hydrolyzable AHL mimics. ...
The libraries were screened for QS modulatory activity using LasR, LuxR, and TraR bacterial reporter strains, and several new, abiotic agonists and antagonists of these receptors were identified. ...
We also thank Karla Camancho for her assistance in purifying members of Library A. ...
doi:10.1016/j.bmc.2011.06.072
pmid:21798749
pmcid:PMC3152649
fatcat:l4dgzunsqvaa5iyvxzxyqqtvoy
Combinatorial Chemistry Online Volume 17, Issue 4, April 2015
2015
Combinatorial Chemistry
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The synthesis of the key compound involved using a molecular diversity approach, to rapidly advance a library of compounds for biological testing. ...
The method is straightforward, high-yield, easy to operate, and shows a broad substrate scope, thus potentially useful for diversity-oriented synthesis [4] . ...
doi:10.1016/j.comche.2015.03.001
fatcat:35hxog5fo5ghrbobbaugb24d4q
Behavioral partitioning in the synthesis of mixed analog-digital systems
2001
Proceedings of the 38th conference on Design automation - DAC '01
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Synthesis of mixed-signal designs from behavioral specifications must address analog-digital partitioning. ...
We present techniques for analog-digital behavioral partitioning of the MSFG, and performance estimation of the technology-mapped analog and digital circuits. ...
In this paper, we address the problem of analog-digital partitioning for synthesis of mixed-signal systems from behavior-level specifications. ...
doi:10.1145/378239.378373
dblp:conf/dac/GanesanV01
fatcat:n7vsartmhrdkzefsml45rmphdi
Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009
2010
Journal of combinatorial chemistry
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Solution-phase methodology accounted for ca. 85% of chemical library synthesis. ...
, 366,367,369 review of Ellman's libraries, 374 solid-phase resin specifications, 359 microelectrode arrays for monitoring ligand-receptor binding events, 364 yactoliter-scale DNA reactor for small molecule ...
Allosteric binding sites, as opposed to traditional orthosteric binding sites, offer unparalleled opportunities for drug discovery by providing high levels of selectivity, mimicking physiological conditions ...
doi:10.1021/cc100128w
pmid:20923157
pmcid:PMC4140011
fatcat:aqvuxwobprbkfbofh2bspbygnm
Light directed massively parallel on-chip synthesis of peptide arrays with t-Boc chemistry
2003
Proteomics
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Examples are given from synthesis of metal ion binding peptides and epitope binding assys. ...
Light directed massively parallel on-chip synthesis of peptide arrays with t-Boc chemistry Peptide and peptidomimetic molecule arrays are emerging powerful tools for parallel screening of binding in proteomics ...
This, coupled with high-throughput synthesis, has the potential to bring the cost of the peptide chips to the level of DNA chips and make them economically viable for everyday use in research. ...
doi:10.1002/pmic.200300597
pmid:14595812
fatcat:4nutujestnb2dbf6dffxquddai
Chemical Dimerizers and Three-Hybrid Systems
2004
Chemistry and Biology
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characterization of small small molecule ligand binding proteins. ...
Traditionally, the molecule-protein interactions and proteome-wide identification of receptors for small molecules has relied identification of drug receptors. on in vitro biochemical methods, such as ...
For example, it was chor moiety" with known binding affinity for the LBD of shown that library screens can be performed at high the DBD-fusion protein, a "test compound" moiety, for complexity and redundancy ...
doi:10.1016/j.chembiol.2003.09.017
pmid:15157871
fatcat:xwkyzbvvnfb5bbqgt5ktzbxkni
Chemical Dimerizers and Three-Hybrid SystemsScanning the Proteome for Targets of Organic Small Molecules
2004
Chemistry and Biology
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characterization of small small molecule ligand binding proteins. ...
Traditionally, the molecule-protein interactions and proteome-wide identification of receptors for small molecules has relied identification of drug receptors. on in vitro biochemical methods, such as ...
For example, it was chor moiety" with known binding affinity for the LBD of shown that library screens can be performed at high the DBD-fusion protein, a "test compound" moiety, for complexity and redundancy ...
doi:10.1016/s1074-5521(04)00119-x
fatcat:inw42qxzezdedk3bhsf7qmm2by
Screening for Diguanylate Cyclase (DGC) Inhibitors Mitigating Bacterial Biofilm Formation
2020
Frontiers in Chemistry
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synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. ...
This review describes currently identified chemical inhibitors that disturb the activity of DGCs and the methods of screening and assay for their discovery. ...
An ideal high throughput screening for chemical inhibitors of DGCs would incorporate a system that monitors the changes of cellular c-di-GMP concentration in situ. ...
doi:10.3389/fchem.2020.00264
pmid:32373581
pmcid:PMC7186502
fatcat:a5usk2g65jexxb5ctdq52wmpoq
Novel Long-Acting Somatostatin Analog with Endocrine Selectivity: Potent Suppression of Growth Hormone But Not of Insulin
2001
Endocrinology
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We employed an integrated approach consisting of screening of backbone cyclic peptide libraries constructed on the basis of molecular modeling of known SRIF agonists and of high throughput receptor binding ...
Its long-acting analogs are in clinical use for treatment of various endocrine syndromes and gastrointestinal anomalies. ...
These SRIF analogs all have similar binding affinities for four of the five human SRIF receptor subtypes (hsst): high affinity for hsst2 and hsst5, moderate affinity for hsst3, and very low affinity for ...
doi:10.1210/endo.142.1.7880
pmid:11145612
fatcat:e27mfvwrgve27is4rtel2j3eda
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