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Association between hypomimia and mild cognitive impairment in de novo Parkinson's disease patients
2020
Canadian Journal of Neurological Sciences
Disease Rating Scale part III; PD-MCI=Parkinson's disease with mild cognitive impairment; PIGD: Postural instability and gait disturbance; TD=tremor dominant; w/o=without. ...
In the present study, more severe hypomimia was associated with PD-MCI and weakly correlated with lower memory scores independently of motor severity and motor phenotype. ...
doi:10.1017/cjn.2020.93
pmid:32406363
fatcat:fewcagw7mneb5mvfgkrksduaca
Detecting Hypomimia Symptoms By Selfie Photo Analysis
2020
Zenodo
Within the EU-funded i-Prognosis project (http://www.i-prognosis.eu), early and unobtrusive Parkinson's disease detection tests are developed, based on the interaction of users with everyday technological ...
Hypomimia, i.e. reduction in the expressiveness of the face, is a cardinal sign of the PD, often present at its early stages. ...
RELATED WORK The effect of hypomimia (masked face) is a common secondary motor symptom of Parkinson's disease [8] . ...
doi:10.5281/zenodo.3678659
fatcat:vntvl2mrlfamplbaeyucbqeloi
Facial emotion recognition in Parkinson's disease: A review and new hypotheses
2018
Movement Disorders
A BST RACT : Parkinson's disease is a neurodegenerative disorder classically characterized by motor symptoms. ...
We therefore undertook a fresh review of relevant articles focusing on facial emotion recognition in PD to deepen current understanding of this nonmotor feature, exploring multiple significant potential ...
Acknowledgments: We warmly thank the National Center for Competence in Research (NCCR) in Affective Sciences at the University of Geneva for supporting Didier Grandjean, as well as Elizabeth Portier for ...
doi:10.1002/mds.27305
pmid:29473661
pmcid:PMC5900878
fatcat:oygxgldkefgdfevf5saizqokxi
Parkinsonism and dementia due to gliomatosis cerebri mimicking sporadic Creutzfeldt-Jakob disease (CJD)
2006
Journal of Neurology, Neurosurgery and Psychiatry
Together with the positive correlation between the decrease in anti-Ri antibodies and immunosuppressive treatment, these results further support the hypothesis of autoimmunity in the pathogenesis of anti-Ri ...
In conclusion, this is the first qualitative evidence of intrathecal anti-Ri specific antibody synthesis. ...
Physical examination revealed extrapyramidal features with hypomimia and a monotonous hypophonic voice. Her gait demonstrated mild bilateral (asymmetric) reduction in arm swing. ...
doi:10.1136/jnnp.2005.072223
pmid:16421148
pmcid:PMC2077600
fatcat:eij6sf6pi5bttmnz52pn55jfcu
Early pathological gambling in co-occurrence with semantic variant primary progressive aphasia: a case report
2019
Clinical Interventions in Aging
To date, no case of PG with the co-occurrence of prominent semantic deficits at the onset of the disease has been reported in the literature. ...
We have comprehensively documented a case of semantic variant of primary progressive aphasia (sv-PPA) presenting with early-onset pathological gambling (PG). ...
At initial neurological examination, the patient presented with mild signs of Parkinson's (ie, bradykinesia, hypomimia) and there was a family history of dementia (his father had Alzheimer's disease). ...
doi:10.2147/cia.s197484
pmid:31114177
pmcid:PMC6497882
fatcat:qjdlzyky6rdv3djjjnhods5arq
Diagnosing the frontal variant of Alzheimer's disease: a clinician's yellow brick road
2017
Journal of Clinical Movement Disorders
An Oz-inspired creative license may help the clinician recognize the differential disease progression, caregiver burden, and treatment response of fvAD compared with bvFTD. ...
Recognizing fvAD from bvFTD-related pathologies is a diagnostic challenge and a critical need in the management and counseling of these patients. ...
National Institute on Aging Alzheimer's Association; PD: Parkinson's disease; UPDRS: Unified Parkinson's disease rating scale
Table 1 1 Clinical features distinguishing fvAD from bvFTD Clinical Features ...
doi:10.1186/s40734-017-0052-4
pmid:28265458
pmcid:PMC5333400
fatcat:g7vsfztt4vcplm4gu5dl4yhj6a
Ekbom Syndrome associated with Lewy Body Dementia: A case report
2020
Dementia & Neuropsychologia
This case report describes the occurrence of Ekbom syndrome in a patient diagnosed with Lewy Body Dementia (LBD), a neurodegenerative disease that commonly presents with sensory perception and thought ...
Proper recognition allows early diagnosis and adequate treatment, preventing hazardous antipsychotic use in these patients. ...
A few studies, with less rigorous methodology in LBD and Parkinson's Disease Dementia, have failed to demonstrate evidence of efficacy of antipsychotics in these conditions. ...
doi:10.1590/1980-57642020dn14-010014
pmid:32206204
pmcid:PMC7077860
fatcat:r5eeryobz5ff7gnyem42wyxgra
Apathy, but Not Depression, Reflects Inefficient Cognitive Strategies in Parkinson's Disease
2011
PLoS ONE
The relationship between apathy, depression and cognitive impairment in Parkinson's disease (PD) is still controversial. ...
The clinical evaluation included: Apathy Evaluation Scale-patient version, Hamilton Depression Rating Scale-17 items, the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr staging system; ...
The authors are grateful to the subjects who kindly volunteered in this study, and acknowledge Dr. Chris Morrison for commenting to the manuscript. ...
doi:10.1371/journal.pone.0017846
pmid:21437255
pmcid:PMC3060914
fatcat:3zpqlvj4kfhodhyxvs3zkyvyue
A Study On Deep Learning And Machine Learning Techniques On Detection Of Parkinson's Disease
2021
E3S Web of Conferences
Parkinson's disease (PD) is a sophisticated anxiety malady that impairs movement. Symptoms emerge gradually, initiating with a slight tremor in only one hand occasionally. ...
The goal of this study is to test the efficiency of deep learning and machine learning approaches in order to identify the most accurate strategy for sensing Parkinson's disease at an early stage. ...
Body bradykinesia, tremor, facial [removed] hypomimia), fidelity of relaxation tremor, and handwriting are the maximum not unusualplace signs and symptoms of Parkinson's disease (micrographia). ...
doi:10.1051/e3sconf/202130901008
fatcat:6hynz3p4gbfphe5exxogcwfaka
Review: The spectrum of clinical features seen with alpha synuclein pathology
2016
Neuropathology and Applied Neurobiology
to diseases characterised by this type of pathology -namely Parkinson's disease (PD) and Lewy body dementia (DLB). ...
In this review we will concentrate on PD, the commonest alpha synucleinopathy, and its associated dementia (PDD), , as well as discussing DLB and MSA and will highlight how the clinical features of these ...
ACKNOWLEDGEMENTS Our own work on the natural history of Parkinson's disease has been supported by the Wellcome Trust; MRC; Patrick Berthoud Trust; Cure Parkinson's Trust; Parkinson's UK and the Cambridge ...
doi:10.1111/nan.12303
pmid:26750431
fatcat:ke274dtuzzcnle5eo4xnsgmolu
Clinical Approach to Progressive Supranuclear Palsy
2016
Journal of Movement Disorders
Since then, in addition to the classic Richardson's syndrome (RS), different clinical phenotypic presentations have been linked with this four-repeat tauopathy. ...
Midbrain atrophy on conventional MRI correlates with the clinical phenotype of RS but is not predictive of PSP pathology. ...
leukoaraiosis), normal pressure hydrocephalus, 57 Parkinson's disease and dementia with Lewy bodies. ...
doi:10.14802/jmd.15060
pmid:26828211
pmcid:PMC4734991
fatcat:camyzkdoxve77mca6ygd4eb6c4
An Unusual Cause of Dementia: Essential Diagnostic Elements of Corticobasal Degeneration—A Case Report and Review of the Literature
2011
International Journal of Alzheimer's Disease
She has been previously diagnosed as unresponsive Parkinson's Disease. ...
Rigidity gradually involved ipsilateral leg; postural instability with falls, blepharospasm, and dysphagia subsequently developed. ...
She has been previously diagnosed as Parkinson's Disease but with no response to levodopa or dopaminergic medications. ...
doi:10.4061/2011/536141
pmid:21785700
pmcid:PMC3139154
fatcat:2aujtv4zfzcoxbkssaxgoxiwh4
Parkinson's disease – pathology, aetiology and diagnosis
2012
Reviews in Clinical Gerontology
Parkinson's disease is a progressive neurodegenerative condition. There is an increasing incidence and prevalence with advancing age and more cases are predicted as the population ages. ...
We present an overview of the pathology, aetiology and differential diagnosis of Parkinson's disease in older people. The importance of specialist medical input in diagnosis is emphasized. ...
It is likely that DLB lies on a continuum with PD, with the separation between the two conditions largely semantic. ...
doi:10.1017/s095925981200007x
fatcat:c32axwztffgthgbpci44idxz4u
Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment
2015
Lancet Neurology
Apathy is highly prevalent in Parkinson's disease (and across many neurodegenerative disorders) and can severely aff ect the quality of life of both patients and caregivers. ...
The opportunity to manipulate dopaminergic treatment in Parkinson's disease allows researchers to study a continuous range of motivational states, from apathy to impulse control disorders. ...
Acknowledgments We would like to thank Mark Jacobs for his help with the preparation of fi gure 3, Saul Martinez-Horta for his expert advice on the psychological bases of human motivation, and Eugénie ...
doi:10.1016/s1474-4422(15)00019-8
pmid:25895932
fatcat:xe5sbp6r55c7xm2r2glkgpjzxm
Suspecting dementia: canaries, chameleons and zebras
2021
Practical Neurology
Dementia is increasingly the business of neurologists and, with ageing populations worldwide, will become even more so in future. ...
We show how clinical intuition reflects underlying signature profiles of brain involvement by the diseases that cause dementia and suggest next steps that can be taken to define the diagnosis. ...
dementia with Lewy bodies Dementia commonly develops in Parkinson's disease (particularly in older patients) and is a core feature of Lewy body pathology. 10 Clues include an early predisposition to ...
doi:10.1136/practneurol-2021-003019
pmid:34215701
fatcat:il6ck6htifay7jvxq2gp4znb7q
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