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Molecular evolutionary analysis of human primary microcephaly genes
2021
BMC Ecology and Evolution
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There has been a rapid increase in the brain size relative to body size during mammalian evolutionary history. In particular, the enlarged and globular brain is the most distinctive anatomical feature of modern humans that set us apart from other extinct and extant primate species. Genetic basis of large brain size in modern humans has largely remained enigmatic. Genes associated with the pathological reduction of brain size (primary microcephaly-MCPH) have the characteristics and functions to
doi:10.1186/s12862-021-01801-0
pmid:33941077
fatcat:fytdm6l4yzb2povgxtsx2stipe
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... e considered ideal candidates to unravel the genetic basis of evolutionary enlargement of human brain size. For instance, the brain size of microcephaly patients is similar to the brain size of Pan troglodyte and the very early hominids like the Sahelanthropus tchadensis and Australopithecus afarensis. The present study investigates the molecular evolutionary history of subset of autosomal recessive primary microcephaly (MCPH) genes; CEP135, ZNF335, PHC1, SASS6, CDK6, MFSD2A, CIT, and KIF14 across 48 mammalian species. Codon based substitutions site analysis indicated that ZNF335, SASS6, CIT, and KIF14 have experienced positive selection in eutherian evolutionary history. Estimation of divergent selection pressure revealed that almost all of the MCPH genes analyzed in the present study have maintained their functions throughout the history of placental mammals. Contrary to our expectations, human-specific adoptive evolution was not detected for any of the MCPH genes analyzed in the present study. Based on these data it can be inferred that protein-coding sequence of MCPH genes might not be the sole determinant of increase in relative brain size during primate evolutionary history.
Genome Warehouse: A Public Repository Housing Genome-scale Data
[article]
2021
bioRxiv
pre-print
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The Genome Warehouse (GWH) is a public repository housing genome assembly data for a wide range of species and delivering a series of web services for genome data submission, storage, release, and sharing. As one of the core resources in the National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB, http://bigd.big.ac.cn/), GWH accepts both whole genome and partial genome (chloroplast, mitochondrion and plasmid) sequences with different assembly levels, as
doi:10.1101/2021.02.10.430367
fatcat:ywnzqmoan5dulgz42xlmfs5y3y
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... well as an update of existing genome assemblies. For each assembly, GWH collects detailed genome-related metadata including biological project and sample, and genome assembly information, in addition to genome sequence and annotation. To archive high-quality genome sequences and annotations, GWH is equipped with a uniform and standardized procedure for quality control. Besides basic browse and search functionalities, all released genome sequences and annotations can be visualized with JBrowse. By February 2021, GWH has received 17,588 direct submissions covering a diversity of 1049 species, and has released 3484 of them. Collectively, GWH serves as an important resource for genome-scale data management and provides free and publicly accessible data to support research activities throughout the world. GWH is accesible at https://bigd.big.ac.cn/gwh/.
Dynamic cellular changes in acute kidney injury caused by different ischemia time
2023
iScience
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Ischemia reperfusion injury (IRI), often related to surgical procedures, is one of the important causes of acute kidney injury (AKI). To decipher the dynamic process of AKI caused by IRI (with prolonged ischemia phase), we performed single-cell RNA sequencing (scRNA-seq) of clinically relevant IRI murine model with different ischemic intervals. We discovered that Slc5a2 hi proximal tubular cells were susceptible to AKI and highly expressed neutral amino acid transporter gene Slc6a19, which was
doi:10.1016/j.isci.2023.106646
fatcat:bicnw7iixfgjtf3usqkfychzse
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... ramatically decreased over the time course. With the usage of mass spectrometry-based metabolomic analysis, we detected that the level of neutral amino acid isoleucine dropped off in AKI mouse plasma metabolites. And the reduction of plasma isoleucine was also verified in patients with cardiac surgery-associated acute kidney injury (CSA-AKI). The findings advanced the understanding of dynamic process of AKI and introduced reduction of isoleucine as a potential biomarker for CSA-AKI.
scMethBank: a database for single-cell whole genome DNA methylation maps
2021
Nucleic Acids Research
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Single-cell bisulfite sequencing methods are widely used to assess epigenomic heterogeneity in cell states. Over the past few years, large amounts of data have been generated and facilitated deeper understanding of the epigenetic regulation of many key biological processes including early embryonic development, cell differentiation and tumor progression. It is an urgent need to build a functional resource platform with the massive amount of data. Here, we present scMethBank, the first open
doi:10.1093/nar/gkab833
pmid:34570235
pmcid:PMC8728155
fatcat:3ha6glowfffs7bzjp3r5ulkowy
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... s and comprehensive database dedicated to the collection, integration, analysis and visualization of single-cell DNA methylation data and metadata. Current release of scMethBank includes processed single-cell bisulfite sequencing data and curated metadata of 8328 samples derived from 15 public single-cell datasets, involving two species (human and mouse), 29 cell types and two diseases. In summary, scMethBank aims to assist researchers who are interested in cell heterogeneity to explore and utilize whole genome methylation data at single-cell level by providing browse, search, visualization, download functions and user-friendly online tools. The database is accessible at: https://ngdc.cncb.ac.cn/methbank/scm/.
Strong bulk-surface interaction dominated in-plane anisotropy of electronic structure in GaTe
[article]
2022
arXiv
pre-print
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Recently, intriguing physical properties have been unraveled in anisotropic layered semiconductors, in which the in-plane electronic band structure anisotropy often originates from the low crystallographic symmetry and thus a thickness-independent character emerges. Here, we apply high-resolution angle-resolved photoemission spectroscopy to directly image the in-plane anisotropic energy bands in monoclinic gallium telluride (GaTe). Our first-principles calculations reveal the in-plane
arXiv:2103.00272v4
fatcat:4bzbtzhb3bh4rowhudfd7x2oze
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... c energy band structure of GaTe measured experimentally is dominated by a strong bulk-surface interaction rather than geometric factors, surface effect and quantum confinement effect. Furthermore, accompanied by the thickness of GaTe increasing from mono- to few-layers, the strong interlayer coupling of GaTe induces direct-indirect-direct band gap transitions and the in-plane anisotropy of hole effective mass is reversed. Our results shed light on the physical origins of in-plane anisotropy of electronic structure in GaTe, paving the way for the design and device applications of nanoelectronics and optoelectronics based on anisotropic layered semiconductors.
Page 138 of Current World Leaders Vol. 29, Issue 2
[page]
1986
Current World Leaders
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The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
Building Industry: ZHOU Jiannan
Aeronautics Industry: LI Xue
Nuclear Industry: JIANG Xinxiong
Electronics Industry: LI Tieying
Ordnance Industry: ZOU Jianhua
Space Industry: ZHANG Jun
Coal Industry: YU Hongen ...
.: TIAN Jiyun
Councillors of State: FANG Yi, GU Mu, KANG Shi’en, CHEN Muhua, J! Pengfei, ZHANG Jingfu, ZHANG Aiping, WU Xueqian, WANG Bingqian, SONG Ping
Ministers:
Foreign Affairs: WU Xuegian
Natl. ...
Page 137 of Current World Leaders Vol. 31, Issue 2
[page]
1988
Current World Leaders
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ZHU Xun
Metallurgical Industry: CHI Yuanpei
State Machine Building Comn.: ZOU Jiahua
Aeronautics Industry: MO Wenxiang
Nuclear Industry: JIANG Xinxiong
Electronics Industry: vacant
Coal Industry: YU Hongen ...
National Governments
State Councillors: FANG Yi, GU Mu, KANG Shi’en, CHEN Muhua, JI Pengfei, ZHANG Jingfu, ZHANG Aiping, WU Xuegian, WANG Bingqian, SONG Ping
Ministers:
Foreign Affairs: WU Xueqian
Natl ...
Page 769 of Current World Leaders Vol. 30, Issue 7
[page]
1987
Current World Leaders
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Yuanpei
State Machine Building Comn.: ZOU Jiahua
Aeronautics Industry: MO Wenxiang
Nuclear industry: JIANG Xinxiong
Electronics Industry: vacant
Coal Industry: YU Hongen
Petroleum Industry. ...
.: CHEN Junsheng
State Councillors: FANG Yi, GU Mu, KANG Shi’en, CHEN Muhua, J! Pengfei, ZHANG Jingfu, ZHANG Aiping, WU Xueqian, WANG Bingqian, SONG Ping
Ministers:
Foreign Affairs: WU Xueqian
Natl. ...
Page 401 of Current World Leaders Vol. 31, Issue 4
[page]
1988
Current World Leaders
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ZHU Xun
Metallurgical Industry: CHI Yuanpei
State Machine Building Comn.: ZOU Jiahua
Aeronautics Industry: MO Wenxiang
Nuclear Industry: JIANG Xinxiong
Electronics Industry: vacant
Coal Industry: YU Hongen ...
.: CHEN Junsheng
State Councillors: FANG Yi, GU Mu, KANG Shien, CHEN Muhua, JI Pengfei, ZHANG Jingfu, ZHANG Aiping, WU Xueqgian, WANG Binggian, SONG Ping, Gen. ...
Page 770 of Current World Leaders Vol. 29, Issue 7
[page]
1986
Current World Leaders
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
.: YU Mingtao
Pres. of the People’s Bank of China: LU Peijian
Commerce: LIU Yi
Foreign Economic Relations and Trade: CHEN Muhua
Agriculture, Animal Husbandry, and Fishery: HE Kang
Forestry: YANG Zhong ...
Building Industry: ZHOU Jiannan
Aeronautics Industry: LI Xue
Nuclear Industry: JIANG Xinxiong
Electronics Industry: LI Tieying
Ordnance Industry: ZOU Jianhua
Space Industry: ZHANG Jun
Coal Industry: YU Hongen ...
Page 402 of Current World Leaders Vol. 30, Issue 4
[page]
1987
Current World Leaders
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
.: LU Peijian
Pres. of the People’s Bank of China: CHEN Muhua
Commerce: LIU Yi
Foreign Economic Relations and Trade: ZHENG Tuobin Agriculture, Animal Husbandry, and Fishery: HE Kang
Forestry: YANG Zhong ...
Industry: CHI Yuanpei
State Machine Building Comn.: ZHO Jiahua
Aeronautics Industry: LI Xue
Nuclear Industry: JIANG Xinxiong
Ordnance Industry: ZOU Jianhua
Space Industry: MO Wenxiang
Coal Industry: YU Hongen ...
Page 731 of Current World Leaders Vol. 28, Issue 10
[page]
1985
Current World Leaders
Preserved Fulltext
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National Governments
Ordnance Industry: ZOU Jianhua
Space Industry: ZHANG Jun
Coal Industry: YU Hongen
Petroleum Industry. ...
Prime Min.: LIN Yang-kang
State: MA Chi-chuang, LI Kwoh-ting, KAO Henry Yu-shu, CHANG Feng-shu, CHOW Hong-tao, CHAO Yao-tung, KUO Wei-fan
Interior. ...
Page 138 of Current World Leaders Vol. 30, Issue 2
[page]
1987
Current World Leaders
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
.: LU Peijian
Pres. of the People’s Bank of China: CHEN Muhua
Commerce: LIU Yi
Foreign Economic Relations and Trade: ZHENG Tuobin
Agriculture, Animal Husbandry, and Fishery: HE Kang
Forestry: YANG Zhong ...
Building Comn.: ZHO Jiahua
Aeronautics Industry: LI Xue
Nuclear Industry: JIANG Xinxiong
Electronics Industry: LI Tieying
Ordnance Industry: ZOU Jianhua
Space Industry: MO Wenxiang
Coal Industry: YU Hongen ...
Page 402 of Current World Leaders Vol. 29, Issue 4
[page]
1986
Current World Leaders
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
.: YU Mingtao
Pres. of the People’s Bank of China: LU Peijian
Commerce: LIU Yi
Foreign Economic Relations and Trade: CHEN Muhua
Agriculture, Animal Husbandry, and Fishery: HE Kang
Forestry: YANG Zhong ...
Building Industry: ZHOU Jiannan
Aeronautics Industry: LI Xue
Nuclear Industry: JIANG Xinxiong
Electronics Industry: LI Tieying
Ordnance Industry: ZOU Jianhua
Space Industry: ZHANG Jun
Coal Industry: YU Hongen ...
Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits
2022
Preserved Fulltext
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The file type is application/pdf.
A broad range of complex phenotypes are related to dysfunctions in brain (hereafter referred to as brain-related traits), including various mental and behavioral disorders and diseases of the nervous system. These traits in general share overlapping symptoms, pathogenesis, and genetic components. Here, we present Brain Catalog (https://ngdc.cncb.ac.cn/braincatalog), a comprehensive database aiming to delineate the genetic components of more than 500 GWAS summary statistics datasets for
doi:10.1093/nar/gkac895
pmid:36243988
pmcid:PMC9825493
fatcat:rwpn534zjzdj5cwrofe6bei62e
more »
... ated traits from multiple aspects. First, Brain Catalog provides results of candidate causal variants, causal genes, and functional tissues and cell types for each trait identified by multiple methods using comprehensive annotation datasets (58 QTL datasets spanning 6 types of QTLs). Second, Brain Catalog estimates the SNP-based heritability, the partitioning heritability based on functional annotations, and genetic correlations among traits. Finally, through bidirectional Mendelian randomization analyses, Brain Catalog presents inference of risk factors that are likely causal to each trait. In conclusion, Brain Catalog presents a one-stop shop for the genetic components of brain-related traits, potentially serving as a valuable resource for worldwide researchers to advance the understanding of how GWAS signals may contribute to the biological etiology of brain-related traits.
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