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Identification of CCL19 as a Novel Immune-Related Biomarker in Diabetic Nephropathy
2022
Frontiers in Genetics
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Biol. 8, 618536. doi:10.3389/fcell.2020.618536 CrossRef Full Text | Google Scholar Keywords: diabetic nephropathy, immune cell, CCL19, bioinformatics, biomarker Citation: Chen H, Zhang Z, Zhou L, Cai ...
Illinois, United States Reviewed by: Navchetan Kaur, Natera, United States Yoshinobu Igarashi, National Institutes of Biomedical Innovation, Health and Nutrition, Japan Copyright © 2022 Chen, Zhang, Zhou, Cai ...
doi:10.3389/fgene.2022.830437
pmid:35222545
pmcid:PMC8864156
fatcat:7fcrv4xxnbattatspl3z7picpy
Modified task-based learning program promotes problem-solving capacity among Chinese medical postgraduates: a mixed quantitative survey
2017
BMC Medical Education
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Despite great advances, China's postgraduate education faces many problems, for example traditional lecture-based learning (LBL) method provides fewer oppotunities to apply knowledge in a working situation. Task-based learning (TBL) is an efficient strategy for increasing the connections among skills, knowledge and competences. This study aimed to evaluate the effect of a modified TBL model on problem-solving abilities among postgraduate medical students in China. Methods: We allocated 228
doi:10.1186/s12909-017-0994-0
pmid:28882184
pmcid:PMC5590117
fatcat:jlwwlr574bfktnwg5fjjhmsww4
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... -year postgraduate students at Third Military Medical University into two groups: the TBL group and LBL group. The TBL group was taught using a TBL program for immunohistochemistry. The curriculum consisted of five phases: task design, self-learning, experimental operations, discussion and summary. The LBL group was taught using traditional LBL. After the course, learning performance was assessed using theoretical and practical tests. The students' preferences and satisfaction of TBL and LBL were also evaluated using questionnaires. Results: There were notable differences in the mean score rates in the practical test (P < 0.05): the number of high scores (>80) in the TBL group was higher than that in the LBL group. We observed no substantial differences in the theoretical test between the two groups (P > 0.05). The questionnaire results indicated that the TBL students were satisfied with teaching content, teaching methods and experiment content. The TBL program was also beneficial for the postgraduates in completing their research projects. Furthermore, the TBL students reported positive effects in terms of innovative thinking, collaboration, and communication. Conclusions: TBL is a powerful educational strategy for postgraduate education in China. Our modified TBL imparted basic knowledge to the students and also engaged them more effectively in applying knowledge to solve real-world issues. In conclusion, our TBL established a good foundation for the students' future in both medical research and clinical work.
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes
2013
Cell Research
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Recent success in the derivation of haploid embryonic stem cells (haESCs) from mouse via parthenogenesis and androgenesis has enabled genetic screening in mammalian cells and generation of gene-modified animals. However, whether haESCs can be derived from primates remains unknown. Here, we report the derivation of haESCs from parthenogenetic blastocysts of Macaca fascicularis monkeys. These cells, termed as PG-haESCs, are pluripotent and can differentiate to cells of three embryonic germ layers
doi:10.1038/cr.2013.93
pmid:23856644
pmcid:PMC3790242
fatcat:g772rkz4rfcqnifon53yf63kfy
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... in vitro or in vivo. Interestingly, the haploidy of one monkey PG-haESC line (MPH1) is more stable compared with that of the other one (MPH2), as shown by the existence of haploid cells for more than 140 days without fluorescence-activated cell sorting (FACS) enrichment of haploid cells. Importantly, transgenic monkey PG-haESC lines can be generated by lentivirus-and piggyBac transposon-mediated gene transfer. Moreover, genetic screening is feasible in monkey PG-haESCs. Our results demonstrate that PG-haESCs can be generated from monkeys, providing an ideal tool for genetic analyses in primates. Cells were plated onto 96-well plate in a density of 500 cells per well. Ten microlitre 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) (Sangon Biotech) with a concentration of 5 mg/ml was added into each well on day 1, 3, 5, 7, 9, 11 and 12 ys. MTT assays were performed as reported previously [30] . PB transfection and insertion site characterization PB (PGK-neo) and ACT-PBase were co-transfected into cells by lipofectamine (Invitrogen). Transfectants were cultured and screened by using G418 with a concentration of 250 µg/ml. To construct PB-PGK-neo-f2, the PGK-neo gene, a 1.7-kb SpeI-MunI fragment from pBigT was cloned into PB (ACT-RFP)DS to make www.cell-research.com | Cell Research Hui Yang et al. 1199 npg PB-PGK-neo-f1, and thena 300-bp fragment from pBigT being cloned into SpeI sites of PB-PGK-neo-f1. For characterization of the insertion sites of PB element, genomic DNA was digested with HaeIII in 37 °C and the products were self-ligated. Then, ligated DNA was used as a template for PCR detection with primers PB-RF and PB-RR to detect the insertion sites as reported previously [34] . Statistical analysis Differences of gene expression levels between groups were analyzed by means of Student's t-test. All statistical analyses were done by SPSS software 13.0. Accession numbers Gene expression and CGH data sets can be accessed as the GEO reference series GSE43980 (http://www.ncbi.nlm.nih.gov/ geo/query/acc.cgi?token=rbsffoccawogyxw&acc=GSE43980). This series includes the GSE43978 (mRNA expression datafrom monkey PG-haESC, diploid ESC and fibroblast) and the GSE43979 (CGH analysis of monkey PG-haESCs) data sets.
Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice
2020
Cell Death and Disease
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Inhibition of sodium-glucose cotransporter 2 (SGLT2) in the proximal tubule of the kidney has emerged as an effective antihyperglycemic treatment. The potential protective role of SGLT2 inhibition on diabetic kidney disease (DKD) and underlying mechanism, however, remains unknown. In this study, metabolic switch was examined using kidney samples from human with diabetes and streptozocin (STZ)-induced experimental mouse model of diabetes treated with or without SGLT2 inhibitor dapagliflozin.
doi:10.1038/s41419-020-2544-7
pmid:32444604
pmcid:PMC7242894
fatcat:2kau27pqvzam5lh5ly2fi4dqcm
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... lts were further validated using primarily cultured proximal tubule epithelial cells. We found that DKD development and progression to renal fibrosis entailed profound changes in proximal tubule metabolism, characterized by a switch from fatty acid utilization to glycolysis and lipid accumulation, which is associated with the increased expression of HIF-1α. Diabetes-induced tubulointerstitial damage, such as macrophage infiltration and fibrosis, was significantly improved by dapagliflozin. Consistent with the effects of these beneficial interventions, the metabolic disorder was almost completely eliminated by dapagliflozin. The increased level of HIF-1α in renal proximal tubule was nearly nullified by dapagliflozin. Moreover, dapagliflozin protects against glucose-induced metabolic shift in PTCs via inhibiting HIF-1α. It suggests that SGLT2 inhibition is efficient in rectifying the metabolic disorder and may be a novel prevention and treatment strategy for kidney tubule in DKD.
Phosphatase, Mg2+/Mn2+ dependent 1B regulates the hematopoietic stem cells homeostasis via the Wnt/β-catenin signaling
2024
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Supplemental Information Phosphatase, Mg 2+ /Mn 2+ Dependent 1B regulates the selfrenewal of HSCs via the Wnt/β-catenin signaling Zhiyuan Lu 1,2,3# , Hanzhi Yu 4# , Yanxia Li 1,2 , Guangsen Xu 1.2 , Xiaoxun ...
doi:10.3324/haematol.2023.284305
pmid:38328859
fatcat:ktnypda3x5bqvgubbtrf5deaae
GEO volume 157 issue 6 Cover and Back matter
2020
Geological Magazine
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Asahara, Ji-Eun Kim and Minoru Ikehara long-term history of sediment inputs to the eastern arabian Sea and its implications for the evolution of the indian summer monsoon since 3.7 Ma 908-919 Mingjiang Cai ...
monsoon, and resulting weathering and surface erosion in the Himalaya-Karakoram Mountains, since late Pliocene time using data from arabian Sea core 864-878 Huayu Lu, Ruixuan Liu, Linhai Cheng, Han Feng, Hanzhi ...
doi:10.1017/s0016756820000606
fatcat:yg2plzxkbfbdda62cmh7ahc2fy
Table of Contents
2021
2021 IEEE MTT-S International Wireless Symposium (IWS)
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Lina Zeng, Deyun Zhou, Xiaoyang Li, Weiren Kong, Weinan Gao (Northwestern Polytechnical University) POSTER Session: TA3P TA3P 13:30 -14:00 Electromagnetic Wave in Neuromorphic Chips (invited) ERPING LI, Hanzhi ...
, Quan Xue, Wenquan Che (Nanjing University of Posts and Telecommunications) P.7 Design of Doherty Power Amplifier Using Load-pull X-Parameters Meilin Wu, Yan Qu, Jia Guo, Chao Yu, Jialin Cai (Hangzhou ...
doi:10.1109/iws52775.2021.9499582
fatcat:skfckfvzezggplsdal2ng4or3m
The Writing of Scholarly Lives in Marginalia
[chapter]
2022
Scholars and Their Marginalia in Late Imperial China
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The colophon at the end of juan 30 of the Xu Hanzhi reads: In the early summer of the xinsi year of the Kangxi reign [1701], I finished reading the thirty juan of the Xu Hanzhi in Shaobo's boat. ...
I chanced to see an incomplete copy of the big character edition which had been carved in the Yijing Hall of Cai Qi (courtesy name Chunfu) in Jian'an in the wuchen year of the Jiading reign in the Song ...
doi:10.1163/9789004508477_006
fatcat:bglvf4k6njas3bfywrwgb3cq5m
ICSMD 2020 Subject Index Page
2020
2020 International Conference on Sensing, Measurement & Data Analytics in the era of Artificial Intelligence (ICSMD)
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North University of China) (14:20-14:40) Structural Design and Simulation Analysis of Silicon Micro Triaxial Wheel-ring Huiliang Cao (North University of China) Rui Zhao (North University of China) Qi Cai ...
Distributed Optical Fiber Sensing Technology ……………………………………180 Yu Chen (Xi'an Jiaotong University) Shuang Wang (Xi'an Jiaotong University) Yi Hao (Xi'an Jiaotong University) Kai Yao (Xi'an Jiaotong University) Hanzhi ...
doi:10.1109/icsmd50554.2020.9261698
fatcat:57iwkh5cvrhvlmblihaaxyd7na
Comparison of chelates for enhancing Ricinus communis L. phytoremediation of Cd and Pb contaminated soil
2016
Ecotoxicology and Environmental Safety
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This is a cost-effective and environmentally friendly technology (Shi and Cai, 2009) . Successful phytoremediation requires a suitable plant for use on the toxicant. ...
., 2008; Shi and Cai, 2009; Zhang et al., 2014a Zhang et al., , 2015 . Castor bean is also an important energy crop for biofuel or biodiesel production but inedible for humans and animals. ...
doi:10.1016/j.ecoenv.2016.05.036
pmid:27414256
fatcat:vmhvcjs3lbbmhcap454x3lecay
Arsenic and antimony co-contamination influences on soil microbial community composition and functions: Relevance to arsenic resistance and carbon, nitrogen, and sulfur cycling
2021
Environment International
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Hanzhi Lin: Writing -review & editing. Xiaoxu Sun: Formal analysis, Visualization. Fuqing Xu: Writing -review & editing. Pin Gao: Writing -review & editing. Tianle Kong: Investigation, Validation. ...
Among these selected genes, arsC is responsible for detoxification and As(V) reduction, aioA promotes As(III) oxidation, and arsA, arsB, and ACR3 mediate the migration and transformation of As (Cai et ...
doi:10.1016/j.envint.2021.106522
pmid:33812041
fatcat:jdqc62cosvbapgavm5cxbexo34
Cadmium accumulation and tolerance of two castor cultivars in relation to antioxidant systems
2014
Journal of Environmental Sciences(China)
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Previous studies reported that the BCF values of the aboveground organs of castor were less than 1 (Shi and Cai, 2009; Huang et al., 2011; Varun et al., 2012) . ...
Discussion A tolerance index based on biomass exposed to heavy metals was used to evaluate the heavy metal toxicity in the plants (Shi and Cai, 2009 Baker (1981) suggested two basic strategies of ...
doi:10.1016/j.jes.2014.08.005
pmid:25288549
fatcat:jpqd2a26nrdufhkwnfwsuggs24
The eastward transition of Chinese culture in the Eastern Han Dynasty and the north-south difference of scholarship & literature in the Eastern Jin, Southern and Northern Dynasties
2008
Frontiers of Literary Studies in China
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Among the famous writers, Cai Yong 蔡邕 and his daughter Cai Yan 蔡琰 were from Chenliuyu 陈留圉 (south to present Qi County 杞县, Henan): Kong Rong was from Lu (present Shandong); Mi Heng 祢 衡, was from Pingyuan ...
For most of the prefectures and principalities, the population recorded in Hanzhi was larger than that in XuHanzhi. Were the records reliable? ...
doi:10.1007/s11702-008-0001-6
fatcat:bju4mx5mdnbz3ltl5sxsqccasq
Technical Program
2020
2020 IEEE MTT-S International Conference on Numerical Electromagnetic and Multiphysics Modeling and Optimization (NEMO)
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Hanzhi
Ma (Zhejiang University)
12:30-12:50
1. ...
Yijun Cai (Xiamen University of Technology), Associate Prof. Yuanguo Zhou (Xi'an University of Science and Technology) and Dr. ...
doi:10.1109/nemo49486.2020.9343628
fatcat:27slpcxmlrd6xc36keul3h5mce
The Collar Revolution: Everyday Clothing in Guangdong as Resistance in the Cultural Revolution
2016
The China Quarterly
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In her memoir, Zhang Hanzhi 章含之, a translator at the Ministry of Foreign Affairs, recalls: "I always wanted to do something different with my clothes. ...
Figure 3 : 3 Citizens Visit a Park Source: Photographed by Minsheng Meng in Guangzhou 1975, Integrated Education Gallery of the Sun Yat-sen University library. 66 Cai 2008, 103. ...
doi:10.1017/s0305741016000692
fatcat:psimzsbv25dtpiygfizjd4wise
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