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Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging
2013
PLoS ONE
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Purpose: To assess whether grating-based X-ray dark-field imaging can increase the sensitivity of X-ray projection images in the diagnosis of pulmonary emphysema and allow for a more accurate assessment ...
Materials and Methods: Lungs from three mice with pulmonary emphysema and three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. ...
(equivalent to a conventional x-ray image), grating based x-ray imaging generates a phase-contrast signal as well as a dark-field signal. [18] The phase-contrast signal represents the first derivative ...
doi:10.1371/journal.pone.0059526
pmid:23555692
pmcid:PMC3608711
fatcat:fvs7ezxkwncprpyuynb3exuwke
Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
2012
Proceedings of the National Academy of Sciences of the United States of America
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Yaroshenko for providing ex vivo mouse projection images. Support for this work was provided by the Deutsche Forschungsgemeinschaft ...
An ex vivo dark-field image of an inflated lung in a mouse (Fig. ...
Chest X-ray is routinely used to screen patients with suspected COPD for emphysema, although it is known that chest X-rays lack sensitivity in mild to moderate emphysema (5) . ...
doi:10.1073/pnas.1206684109
pmid:23074250
pmcid:PMC3497797
fatcat:c7jdoneftjf7titpstqgpwoupi
Visualization of neonatal lung injury associated with mechanical ventilation using x-ray dark-field radiography
2016
Scientific Reports
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This so-called dark-field signal revealed increasing loss of x-ray small-angle scattering when comparing images of neonatal mice undergoing hyperoxia and MV-O 2 with animals kept at room air. ...
The changes in the dark field correlated well with histologic findings and provided superior differentiation than conventional x-ray imaging and lung function testing. ...
the x-ray transmission and the dark-field imaging technique. ...
doi:10.1038/srep24269
pmid:27072871
pmcid:PMC4829826
fatcat:7qfwzw4dcndxxezjmmegt7d2cq
Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography
2011
Journal of applied physiology
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Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. ...
We measured dynamic changes in vessel diameter in response to acetylcholine (ACh) and acute exposure to hypoxic gas (10% O2). ...
GRANTS This work was supported in part by a Research Grant for Cardiovascular Disease (21A-13) from the Ministry of Health, Labour, and Welfare of Japan and a Grant-in-Aid for Scientific Research (20590242 ...
doi:10.1152/japplphysiol.00205.2011
pmid:21527665
fatcat:5a5fjgq7lvfbpmbofnxurnpmo4
MÖNCH detector enables fast and low-dose free-propagation phase-contrast computed tomography of in situ mouse lungs
2018
Journal of Synchrotron Radiation
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Synchrotron-based in-line phase-contrast computed tomography imaging has been successfully applied in lung research in various applications, but mostly at dose levels that forbid longitudinal in vivo studies ...
Due to the complexity of the underlying pathomechanism, in vivo mouse lung-disease models continue to be of great importance in preclinical respiratory research. ...
Acknowledgements The authors thank Andrea Lorenzon from the animal facility of University Trieste for preparation of the mice. ...
doi:10.1107/s160057751701668x
pmid:29488938
pmcid:PMC5829681
fatcat:7vjle2jmoregnciqoqejbbuh5q
Non-ionizing Label-free Photoacoustic Imaging of Bones
2020
IEEE Access
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X-ray based radiography, the main modality for diagnostic imaging of bone structures and fractures, provides sensitive images, but it inherently involves potentially harmful X-ray exposure. ...
Here, we demonstrate nonionizing, label-free, multispectral photoacoustic (PA) imaging of bones in small animals in vivo, in situ, and ex vivo. ...
INTRODUCTION Since Röntgen discovered X-rays in 1895, X-ray radiography has been extensively developed as a main diagnostic tool in medicine. ...
doi:10.1109/access.2020.3020559
fatcat:mz62dp5bwbdfbf3ssdssnygzye
Front Matter: Volume 10132
2017
Medical Imaging 2017: Physics of Medical Imaging
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x-ray phase contrast imaging with a photon counting detector 10132 5K High resolution laboratory grating-based x-ray phase-contrast CT 10132 5L First experiences with in-vivo x-ray dark-field imaging ...
of lung cancer in mice xiv Proc. of SPIE Vol. 10132 1013201-14 Classification of the micromorphology of breast calcifications in x-ray dark-field mammography 10132 5N Phase unwrapping with differential ...
Physics of Medical Imaging Poster Presentation Awards sponsored by Siemens Healthineers Cum Laude: Paper 10132-145, "High spatial resolution performance of pixelated scintillators," Kazuki Shigeta, Toray ...
doi:10.1117/12.2276763
fatcat:5vgmgqm4izfdrl6p4itkq6fsjm
Multimodal Precision Imaging of Pulmonary Nanoparticle Delivery in Mice: Dynamics of Application, Spatial Distribution, and Dosimetry
2019
Small
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It is demonstrated that in vivo propagation-based phase-contrast X-ray imaging elucidates the dynamic process of pulmonary NP delivery, while ex vivo fluorescence imaging (e.g., tissue-cleared light sheet ...
This study introduces a preclinical imaging platform combining X-ray (two modes) and fluorescence imaging (three modes) techniques for time-resolved in vivo and spatially resolved ex vivo visualization ...
Image Processing and Analysis: All (X-ray and CT) images were flat field and dark current corrected. ...
doi:10.1002/smll.201904112
pmid:31639283
fatcat:vghfozrd5vdhxp43ede47moavi
A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source
2009
Physics in Medicine and Biology
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In this paper, we present a prototype physiologically gated micro-computed tomography (micro-CT) scanner based on a carbon nanotube field emission micro-focus x-ray source. ...
The novel x-ray source allows x-ray pulses and imaging sequences to be readily synchronized and gated to non-periodic physiological signals from small animals. ...
We would also like to thank Dr E Hoffman of the Department of Radiology at University of Iowa for his helpful discussions and Drs H Geng and B Gao of Xintek for assistance in carbon nanotube cathode fabrication ...
doi:10.1088/0031-9155/54/8/005
pmid:19321922
fatcat:ggpvi2gldfdwpn7adkwtgrgbau
High-resolution visualization of airspace structures in intact mice via synchrotron phase-contrast X-ray imaging (PCXI)
2008
Journal of Anatomy
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Here we report the ability of phase-contrast synchrotron X-ray imaging to provide detailed two-and three-dimensional visualization of airspace organ structures in intact animals. ...
Anatomical visualization of airspace-containing organs in intact small animals has been limited by the resolution and contrast available from current imaging methods such as X-ray, micro-computed tomography ...
All captured images were conventionally corrected for dark-current offset and flat-field non-uniformity before being digitally tiled to form a composite image. ...
doi:10.1111/j.1469-7580.2008.00950.x
pmid:19172736
fatcat:bbqrzj43kzcclaxf2ksedn3muy
Toolbox for In Vivo Imaging of Host–Parasite Interactions at Multiple Scales
2019
Trends in Parasitology
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X-ray-based and gamma-ray-based imaging platforms are noninvasive and enable the study of anatomical structures, metabolism, biochemical composition of tissues, and dynamics. ...
Here we discuss advances and challenges in the in vivo imaging toolbox, which hold promising potential for the field of parasitology. ...
These include X-ray attenuation, X-ray fluorescence, and X-ray-excited optical luminescence (reviewed in [156, 157] ). ...
doi:10.1016/j.pt.2019.01.002
fatcat:2esiacynafdife2tnvv53czelm
Longitudinal assessment of lung cancer progression in the mouse using in vivo micro-CT imaging
2010
Medical Physics (Lancaster)
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Results: In vivo micro-CT data sets were acquired at months 2, 3, and 4 posturethane administration in cancer mice ͑n=5͒ and simultaneously in control mice ͑n=3͒. 137 unique lung nodules were identified ...
from the cancer mice while no nodules were detected in the control mice. ...
In addition, the authors would like to thank Jered Sieren for his CT support and Bridget Zimmerman for her expertise in the statistical analysis. This project was supported in part via NIH Grant No. ...
doi:10.1118/1.3476454
pmid:20964199
pmcid:PMC2937054
fatcat:6bko2iolnzbtbk5wpqzifuzqme
Synchrotron Radiation-Based Refraction-Contrast Tomographic Images Using X-ray Dark-Field Imaging Optics in Human Lung Adenocarcinoma and Histologic Correlations
2021
Diagnostics
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A refraction-based tomographic imaging technique called the X-ray dark-field imaging (XDFI) method was used to obtain computed tomographic images of human lung adenocarcinoma at the beam line at Photon ...
Hyperplasia of interstitial tissue and dysplasia of alveolar structures were noticed in images of lung adenocarcinoma. ...
One research of dynamic in vivo imaging of mice lung was reported. [25] . ...
doi:10.3390/diagnostics11030487
pmid:33801895
pmcid:PMC7999731
fatcat:7623wrmmlzbdxm2bklu6lkwevm
Preclinical anatomical, molecular, and functional imaging of the lung with multiple modalities
2014
American Journal of Physiology - Lung cellular and Molecular Physiology
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In this review, we highlight the fundamental principles of bioluminescence, fluorescence, planar X-ray, X-ray computed tomography, magnetic resonance imaging, and nuclear imaging modalities (such as positron ...
In vivo imaging bridges molecular biological studies, drug design and discovery, and the imaging field with modern medical practice, and, as such, will continue to be a mainstay in biomedical research. ...
GRANTS This work was supported in part by a grant awarded by Children's Healthcare of Atlanta to M. N. Helms. ...
doi:10.1152/ajplung.00007.2014
pmid:24658139
fatcat:wmtxzpz44vbchk4hk6pegu7egq
Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement
2012
Journal of the Royal Society Interface
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the mammalian lung in vivo. ...
Measurements of lung expansion and airflow in mice and rabbit pups are shown to agree with independent measures. ...
Radiation dose is an important consideration for in vivo X-ray CT. The dose delivered during imaging at an energy of 24 keV on the beamline used is approximately 2 mGy s 21 [24, 25] . ...
doi:10.1098/rsif.2012.0116
pmid:22491972
pmcid:PMC3405755
fatcat:d6fyegah4jdxbfuzhoyp2r4znq
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