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Cyclizing Clusters via Zeta Function of a Graph
2008
Neural Information Processing Systems
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A new mathematical tool, Zeta function of a graph, is introduced for the integration of all cycles, leading to a structural descriptor of a cluster in determinantal form. ...
To this end, we develop an algorithm named Zeta l-links (Zell) which consists of two parts: Zeta merging with a similarity graph and an initial set of small clusters derived from local l-links of samples ...
We are also grateful of the interesting discussion with Yi Ma and John Wright on clustering and classification. Feng Li and Xiaodi Hou are acknowledged due to their kind help. ...
dblp:conf/nips/ZhaoT08
fatcat:l5i3xv5pifdkpjrx3zup4otzsq
Synthesis, Characterization and Biocompatibility of a Multifunctional Gold Nanoparticle System for the Delivery of Single-Stranded RNA to Lymphocytes
2018
South African Journal of Chemistry
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This strategy is based on a PEGylated gold nanoparticle scaffold covalently linked to the thiol-modified oligoribonucleotide via a cleavable N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) linker ...
A synthetic anti-CD4 cyclic targeting peptide was attached to the polyethyleneimine-coated nanoparticle via an SPDP linker molecule, in an attempt to enhance uptake and selectivity. ...
Dr Louis Chonco, under the supervision of Dr R. Parboosing, performed the experiments to provide a positive control and assisted with the images for Fig. 6 . ...
doi:10.17159/0379-4350/2018/v71a1
fatcat:seqse3wsureefarfbe2sfqj5oa
Joint Unsupervised Learning of Deep Representations and Image Clusters
[article]
2016
arXiv
pre-print
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Extensive experiments show that our method outperforms the state-of-the-art on image clustering across a variety of image datasets. ...
In this paper, we propose a recurrent framework for Joint Unsupervised LEarning (JULE) of deep representations and image clusters. ...
A.8. Clustering based on Hand-Crafted Features We also evaluate the performance of clustering based on image features, instead of image intensities. ...
arXiv:1604.03628v3
fatcat:uzzpuxn7ynbc7bw3qi4gcucvzq
Regio- and Stereoselectivity of CYP450BM3-Catalyzed Oxidation of Complex Terpenoids: A QM/MM study
2020
Physical Chemistry, Chemical Physics - PCCP
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The site-selective C-H oxidation of terpenoids by P450 attracts great attention because of their wide range of biological activities. ...
However, the binding and catalytic mechanism of P450 for hydroxylation of... ...
The distance in this graph was from Cluster 0. In the optimized reactant of X-E12-arteminsinin (Figure 5 ), the distance between the Fe(IV)=O and C6a was 3.13 Å. ...
doi:10.1039/d0cp03083j
pmid:32969450
fatcat:xbhzbvhw3vdmfncrqazacfi6fe
An overview of multiscale molecular modelling and simulation of silica aerogels
2019
Industrial & Engineering Chemistry Research
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In principle, the electron distribution of any molecular system can be obtained by solving the time-independent Schrödinger equation, where ψ(r) is the wave function (whose square gives the probability ...
tens of nanometers), creating a sol 13 : Because of the low positive partial charge of Si atoms in the silica alkoxysilane precursors (δ Si = +0.32), compared to other metal alkoxides 9 , hydrolysis and ...
clusters undergone cyclization. ...
doi:10.1021/acs.iecr.9b03781
fatcat:pv2vmu7minhs5jjbbgf22lqfle
De Novo Transcriptomic Analysis of an Oleaginous Microalga: Pathway Description and Gene Discovery for Production of Next-Generation Biofuels
2012
PLoS ONE
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for the molecular genetics and functional genomics required to direct metabolic engineering efforts that seek to enhance the quantity and character of microalgae-based biofuel feedstock. ...
These reads were assembled into 75,632 unigenes with a mean size of 503 bp and an N50 of 663 bp, ranging from 100 bp to .3,000 bp. ...
However, the in vivo function of PDAT still remains to be determined via gene-knockout experiments and analysis of lipid profiles. Figure 6A ). ...
doi:10.1371/journal.pone.0035142
pmid:22536352
pmcid:PMC3335056
fatcat:zex4jkpuuncqpev3bioob7kjcu
Integrated Four Comparative-Omics Reveals the Mechanism of the Terpenoid Biosynthesis in Two Different Overwintering Cryptomeria fortunei Phenotypes
2021
Frontiers in Plant Science
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Among them, 8346 targets of 571 miRNAs were predicted using degradome data, and a 72-miRNA-target regulatory network involved in the metabolism of terpenoids and polyketides was constructed. ...
A total of 1447/6219 differentially synthesized metabolites (DSMs)/unigenes (DEGs) were detected through metabolome/transcriptome analyses, and these DSMs/DEGs were significantly enriched in flavonoid ...
and participates in carotenoid biosynthesis; (2) via a reaction catalyzed by geranylgeranyl reductase ( GGR ), GGPP eventually forms the phytol side chain of chlorophyll; and (3) via a reaction catalyzed ...
doi:10.3389/fpls.2021.740755
pmid:34659308
pmcid:PMC8513690
fatcat:6wjzprt7xnc7vjzckbkn6b4czi
Scientific Abstracts presented at the 5th International Convention of Association of Pharmacy Professionals: Redesigning Pharmacy Education and Regulations for Translational Drug Research in India, hosted at Anna University, Centre for Excellence in Nanob
2016
European Journal of Molecular and Clinical Medicine
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, proving the alkaloid to be a promising small molecule for chemoprevention. ...
The alkaloid shows ROS dependent cytotoxicity with accumulation of cells in the Go/G1 phase of cell cycle. ...
The zeta potential was À 30 to À 35 indicating formulations were stable. The drug content of formulations was found to more than 95%. ...
doi:10.1016/j.nhtm.2016.01.001
fatcat:25jytfyueff4pfjaqpaoulhtcq
Discussions of Fluorescence in Selenium Chemistry: Recently Reported Probes, Particles, and a Clearer Biological Knowledge
2021
Molecules
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Typically, the selenium is part of the reactive, or active site of the probe; in other cases, it is featured as the analyte, either as a reduced or oxidized form of selenium. ...
Selenium serves as a constituent for some small molecule sensors and probes. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/molecules26030692
pmid:33525729
pmcid:PMC7866183
fatcat:5euxnt2syjgfrdxye3isd6begu
Award Winners and Abstracts of the 31st Annual Symposium of The Protein Society, Montreal, Canada, July 24-27, 2017
2017
Protein Science
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limited to a 250nm resolution). ...
RESULTS and CONCLUSIONS: This ExPath protocol enabled expansion of human normal and cancer tissues $4.5x in linear dimension and $100x in volume, with a post-expansion measurement error of <5%. ...
POS058 Incorporating a functional mutation into a symmetric scaffold as proxy for functional adaptation via rearrangement of its folding nucleus. ...
doi:10.1002/pro.3349
pmid:29280217
fatcat:jrxtwzblare37gxsvc5szbwuhu
Nanomedicine for respiratory diseases
2009
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
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Treatment of respiratory diseases and infections has proved to be a challenging task, with the incidence of these ailments increasing worldwide. ...
Nanotechnologybased drug and gene delivery systems offer a possible solution to some of the shortfalls of the current treatment regimen. ...
For the ideal situation and known contrast agent relaxivities, these effects can be modeled via the Bloch equation 86, 87 to predict signal intensity as a function of agent concentration for a given ...
doi:10.1002/wnan.33
pmid:20049795
fatcat:rdcc5ol3pfcmxm4efd2igzlaly
Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications
2021
Polymers
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In the determination of the bioavailability of drugs administered orally, the drugs' solubility and permeability play a crucial role. ...
As a result, a broadly diverse spectrum of natural or artificially synthesized polymers capable of enzymatic hydrolysis, hydrolyzing, or enzyme decomposition are being explored for biomedical purposes. ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/polym13162623
pmid:34451161
pmcid:PMC8399915
fatcat:o7vu4j7z5zey5iwspt3zckqlka
Effects of a new conjugate drug in a rat model of postmenopausal osteoporosis
2013
Bone Abstracts
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Postmenopausal osteoporosis is a disease characterized by bone loss and increased risk of fracture, and represents a significant burden on the Canadian health care system. ...
This study investigated the in vivo efficacy of this drug in a curative experiment to treat postmenopausal osteoporosis using an ovariectomized rat model. ...
different types of bone cells, each with a unique function in the maintenance of bone. ...
doi:10.1530/boneabs.1.pp394
fatcat:bw7ykvkdkjbhtopdkvwinqoaly
Reviewing methods of deep learning for diagnosing COVID-19, its variants and synergistic medicine combinations
2023
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By summarizing these findings, we aim to assist future researchers in their endeavours by providing a comprehensive overview of the implication of DL techniques in COVID-19 detection and treatment. ...
We conducted an exploration and comparison of several diagnostic techniques that are widely used and globally validated for the detection of COVID-19. ...
Acknowledgement This study is supported via funding from Prince sattam bin Abdulaziz University project number (PSAU/2023/R/1444). ...
doi:10.1016/j.compbiomed.2023.107191
pmid:37354819
pmcid:PMC10281043
fatcat:ahvylfr3ufca7crx3vaj7a45wy
Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease
2019
Neurobiology of Disease
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of the project, we thank Mrs. ...
Gilles Chabot for art work and the Bioimaging platform of the Infectious Disease Research Centre, funded by an equipment and infrastructure grant from the Canadian Foundation for Innovation, for the coordination ...
The graphs display a V shape, as expected, and only the proteins falling outside the limits of a p value < 0.05 and absolute value of z-score > 1.96 (identified by black lines) were considered as variant ...
doi:10.1016/j.nbd.2018.11.002
pmid:30408591
fatcat:ban7kqlpzfb2dcktbmooy52is4
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