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The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation
2014
PLoS Computational Biology
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This work shows that tight coupling of computational and experiments approaches can yield improved understanding of complex pathways. ...
of R-Smad was a fast-mode effect. ...
) for guidance of KroneckerBio toolbox. ...
doi:10.1371/journal.pcbi.1003573
pmid:24901250
pmcid:PMC4105941
fatcat:ljcyh5moyrblxaqanvcwiowxsm
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
2002
Endocrine reviews
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These investigations have revealed that TGF- superfamily ligands, receptors, SMADs, and upstream and downstream regulators function in diverse developmental and physiological pathways. ...
Most ligands of the family signal through transmembrane serine/ threonine kinase receptors and SMAD proteins to regulate cellular functions. ...
TGF- also promotes the formation of a complex containing SMAD3, the anaphase-promoting complex, and SnoN, which leads to SnoN ubiquination and degradation (125) . ...
doi:10.1210/er.2002-0003
pmid:12466190
fatcat:njkqkvrblzfrdhzrtxf3vqitnm
Insights into Bone Morphogenetic Protein—(BMP-) Signaling in Ocular Lens Biology and Pathology
2021
Cells
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Bone morphogenetic proteins (BMPs) are a diverse class of growth factors that belong to the transforming growth factor-beta (TGFβ) superfamily. ...
In this review, we summarize recent insights in this topic and discuss the complexities of BMP-signaling including the role of individual BMP ligands, receptors, extracellular antagonists and cross-talk ...
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/cells10102604
pmid:34685584
pmcid:PMC8533954
fatcat:cuvoqlqrozfsnfulgbigy5kj5a
The Smad3 linker region: transcriptional activity and phosphorylation-mediated regulation
2008
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The phosphorylation triggers heteromeric complex formation with Smad4 and the translocation of the Smads into the nucleus, where they recruit co-activators, co-repressors and other transcription factors ...
We have found that the linker region of Smad3 contains a transcriptional activation domain. ...
Thus, Smad2 binding to both Smurf2 and SnoN brings together the two proteins into a Smurf2-Smad2-SnoN ternary complex. ...
doi:10.7282/t3v1256q
fatcat:ct3rftz3andntf4xmbqxzvhkbi
Systems biological analyses of intracellular signal transduction
[article]
2017
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Finally, a reverse engineering approach is applied to derive the topology of a complex mammalian transcription factor network from high-throughput knock-down data. ...
Dynamic data-based modelling identifies the SnoN oncoprotein as the central negative feedback regulator in the TGFbeta signalling pathway, and corresponding model predictions are verified experimentally ...
I had lots of fun and exciting discussions with my room-mates, especially with Nils, Pål, Adrian, Kasia, and James. In particular, Nils contributed a large part to this thesis. ...
doi:10.18452/16018
fatcat:hwacpk76yfdzjj2jhmero4xrgq
Society for Development Biology 64th Annual Meeting
2005
Developmental Biology
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We are using molecular and computational approaches to identify micro-RNAs in plants and animals and then investigate their functions. ...
during Arabidopsis development; improved methods for computational identification of microRNA regulatory targets in animals, which indicate that more than a third of the human genes are conserved microRNA ...
FoxH1 is a co-transcription factor recruited by activated Smad2/Smad4 and Smad3/Smad4 downstream of several TGFhs, including Nodals. ...
doi:10.1016/j.ydbio.2005.04.040
fatcat:jj63lzrujnfx7pt3uxl57spp4i
Thyrotropin Receptor
[chapter]
2018
Encyclopedia of Signaling Molecules
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Acknowledgments SSM is a recipient of Malaysian governmental scholarship. ...
Acknowledgments Dimitra Vyrla was supported through the action "Funding of Postdoctoral Researchers" of the Operational Program "Development of Human Resources, Education and Lifelong Learning," 2014-2020 ...
i •eIF2•GTP ternary complex. ...
doi:10.1007/978-3-319-67199-4_101925
fatcat:uv6mzuosqfblhbycpc64ojzb5i
Targeting cell motility and dissemination in medulloblastoma
2017
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Using cells derived from patient derived xenografts and ex vivo slice culture models, this study identified bFGF as a central component of micro--environmental control of pro-metastatic tumour cell functions ...
This project identified a novel target to specifically inhibit MB cell dissemination and has unraveled a unique crosstalk dependent regulation of metastatic capabilities of MB cells. ...
., and from the University of Zürich, Forschungskredit (FK-13-039), to G.F. ...
doi:10.5167/uzh-204880
fatcat:65vhijbd5nb7pif3bimug6rjym