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Participatory Design of Nature-Based Solutions: Usability of Tools for Water Professionals
2022
Sustainability
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There is a diversity of rapidly evolving participatory methods, here defined, as tools for supporting the process of designing nature-based solutions (NbS) together with the stakeholders. ...
However, this requires a systematic and informed selection to facilitate the adequate choice of tools, aligned to the requirements and context of the water professionals and the stakeholders for the design ...
The idea is to combine the NbS planning framework with a more practitioner-oriented workflow for participatory modeling to adapt to the needs of our WPs in the project. ...
doi:10.3390/su14095562
doaj:f1a5e67eb9ea41848bd90532620ec788
fatcat:vdkcn2t3ongu5fms4ec4mtrv24
94th National Congress of the Italian Society for Experimental Biology | Torino, Italy, 6-9 April 2022
2022
Journal of Biological Research
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We here first describe sensory impairment in centenarians, centenarian's offspring and a group of controls recruited in Milano, Bologna and Calabria regions at phenotypic level (N=202). ...
Then we identified the most significant genetic signals associated to sensory impairment for the Italian populations and then we investigated them in a whole genome sequencing dataset of Italian semi-supercentenarians ...
CCT5 NCP. ...
doi:10.4081/jbr.2022.10494
fatcat:c5qlpy75cfadnfmnfii3cywaf4
93rd National Congress of the Italian Society of Experimental Biology | Palermo, Italy, 22-25 April 2021
2021
Journal of Biological Research
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The data attest that a 4-week training based on posture management, a step frequency training, and targeted muscle training can induce significant changes in non-professional runners whose running posture ...
The research design is a randomized pre/post study, with an experimental group who performs a specific Feldenkrais Method® training protocol. ...
MORPHOLOGICAL STUDY ON THE OVARY OF A DEHYDROEPIANDROSTERONE-INDUCED MODEL OF POLYCISTIC OVARIAN SYNDROME IN MOUSE Maria Grazia PALMERINI, Carla TATONE, Giovanna DI EMIDIO, Guido MACCHIARELLI Department ...
doi:10.4081/jbr.2021.9820
fatcat:4yqk4yufsnayvanfiztusrj5iq
Target selection by natural and redesigned PUF proteins
2015
Proceedings of the National Academy of Sciences of the United States of America
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The mutant protein finds its target site in 1,800 RNAs and yields a novel RNA network with a dramatic redistribution of binding elements. ...
Lapointe, A. Prasad, E. Sorokin, and B. Carrick for comments; L. ...
This work was supported by a gift from D.F.P., and NIH Grants R01 GM050942 (to M.W.) and T32 GM008349 (to D.F.P.). ...
doi:10.1073/pnas.1508501112
pmid:26668354
pmcid:PMC4703012
fatcat:y3vhgdugoretdayjwygr2uh4ia
A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle
2024
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PhLP2A NTD undergoes an orientation change of about ~50 Å from extended outward to bent inward, closer to the TXD. ...
(ii) Three representative structures of AlphaFoldpredicted full-length models of PhLP2A, color-coded in a domain-wise manner and (iii) superposition of the three models with the experimental model. f Intramolecular ...
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. ...
doi:10.3929/ethz-b-000659408
fatcat:xrewejimdzewhpzw5fhi6jh2te
Predicting molecular phenotypes from histopathology images: a transcriptome-wide expression-morphology analysis in breast cancer
[article]
2020
arXiv
pre-print
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We report the first transcriptome-wide Expression-MOrphology (EMO) analysis in breast cancer, where gene-specific models were optimised and validated for prediction of mRNA expression both as a tumour ...
Molecular phenotyping is central in cancer precision medicine, but remains costly and standard methods only provide a tumour average profile. ...
Training We applied transfer learning to speed up model convergence by training an Inception V3 9 deep convolutional neural network (CNN) initialised with weights pre-trained on ImageNet 10 . ...
arXiv:2009.08917v1
fatcat:kdgt7hbvv5glfjx2itl6se66se
The Rotterdam Study: 2016 objectives and design update
2015
European Journal of Epidemiology
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It also presents a summary of the major findings and an update of the objectives and methods. ...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. ...
link to the Creative Commons license, and indicate if changes were made. ...
doi:10.1007/s10654-015-0082-x
pmid:26386597
pmcid:PMC4579264
fatcat:d3o3whwsnbfuraxnei4t5bd7gq
The Rotterdam Study: 2014 objectives and design update
2013
European Journal of Epidemiology
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It also presents a summary of the major findings and an update of the objectives and methods. ...
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. ...
a genetic locus involved in pain, i.e., CCT5 [150] . ...
doi:10.1007/s10654-013-9866-z
pmid:24258680
fatcat:666rtkgdwfdktchdovsbifco24
D3.2 - Project Manual – CoBraD RWD, Updated MES-CoBraD Protocols and Quality and Quantity (Q&Q) Evaluation – v2
2021
Zenodo
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On this basis, it is a reference for users involved in the MES-CoBraD Project. ...
The current Project Manual (PM) aims to be a continuously updated reference on (a) metrics that are assessed in people with CoBraD belonging to the above categories of RWD, (b) their systematic and standardised ...
The computed outcomes from the QC processing can be used to establish thresholds for usability, or to train machine learning models to automatically prompt a quality status of the input images. ...
doi:10.5281/zenodo.5544021
fatcat:dni43s2gjrddpidxhrxolo5xly
Poster Session 2, Monday 27 September
2010
European Journal of Neurology
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Methods: In a cross-sectional study, we assessed pain in patients with MS using a symptom-oriented approach. ...
P2534 The neurobiology of sexual orientation J. ...
Results: Two coding mutations in exon 7 of the MAPT gene were identified (p.A123T and a p.A149T). ...
doi:10.1111/j.1468-1331.2010.03233.x
fatcat:lsellp2xyvc77c7gr7qbzu6coi
Project Manual – CoBraD RWD, Updated MES-CoBraD Protocols and Quality and Quantity (Q&Q) Evaluation
2021
Zenodo
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The file type is application/pdf.
On this basis, it is a reference for users involved in the MES-CoBraD Project. ...
The current Project Manual (PM) aims to be a continuously updated reference on (a) metrics that are assessed in people with CoBraD belonging to the above categories of RWD, (b) their systematic and standardised ...
The computed outcomes from the QC processing can be used to establish thresholds for usability, or to train machine learning models to automatically Each site is expected to store its acquired data following ...
doi:10.5281/zenodo.5106495
fatcat:v42dckgrujdwvajhcpdzgiasaq
Retinal Mechanisms Controlling Eye Growth in Experimental Myopia
2023
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Submission note: A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Psychology and Public Health, College of Science, Health and Engineering ...
You have both made this journey a sane one To my family and friends who have been waiting for this moment for several years, thank you for nagging but ultimately for your constant support and patience. ...
No significant outliers were found in either forms of pre-processing therefore we chose to present the data that was modelled together. ...
doi:10.26181/21854382.v1
fatcat:mohwyuvolfgklnpmrwl3qr2yce
Translating tourism: a cultural journey across conceptual spaces
2017
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The theoretical aspect is represented by the CCT model, while the practical aspect is represented by the application of the CCT model in a translation project conducted in a simulated commercial-world ...
I address this cross-cultural challenge by proposing a translation model - the cultural-conceptual translation model (CCT) - which identifies effective strategies for the translation of TPMs. ...
Discover Melbourne's secrets and explore regional Victoria with a great range of sightseeing tours. ...
doi:10.4225/03/58ae4510ac541
fatcat:x5jb3wzh6vhlpdnosv5hyioopq
Understanding the biology of transforming growth factor-β in colorectal cancers
2022
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The changes in these model systems following active TGFβ1 treatment were investigated using state-of-the-art proteomics and a cell signalling assay (i.e., AlphaScreen® SureFire® Assay) technologies in ...
These results determined that malignancy was attained in a TGFβ-dependent manner when β6 was expressed or in a TGFβ-independent manner when uPAR was expressed. ...
and are a suitable models for early stages of metastasis. 1 . ...
doi:10.25949/19444655.v1
fatcat:2nabgsk2kzdhfgvletl24rz7n4
The αvβ6 integrin plays an integral role in promoting metastatic phenotypes in colorectal cancer
2022
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This was achieved by employing five CRC cell lines as model cellular systems, in which β6 had been artificially overexpressed, suppressed or truncated (SW480Mock, SW480β6OE, SW480β6DEL, HT29Mock, HT29β6AS ...
TGFβ receptor signalling, plasmin activity or the uPAR•αvβ6 interaction. β6 overexpression and suppression induced extensive proteomic changes, altering pivotal biomolecular pathways that can be associated ...
This study demonstrates that TGFβ can exert critical proteomic and phenotypic changes within a pre-metastatic CRC cell to promote functions crucial for metastasis, and that these changes are potentiated ...
doi:10.25949/19433117.v1
fatcat:zhhzpsmdx5epdox5nwwtfgdt5i
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