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A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations
2013
Proceedings of the National Academy of Sciences of the United States of America
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(C) In vivo killing of CSP-or L3-coated target cells in naïve mice (open squares) or mice immunized with 3× RAS (filled squares), CSP peptide-pulsed DCs (open triangles), 3× RAS then CSP peptide-pulsed ...
(E) In vivo killing of CSP-or L3-coated target cells as in C in mice receiving CSP-pulsed DC priming and no booster immunization (open triangles), CSP DC priming and single RAS booster (filled triangles ...
doi:10.1073/pnas.1303834110
pmid:23530242
pmcid:PMC3625320
fatcat:jh4tlllpljg2vpsdlo35vbm7me
Epitope masking may limit antibody boosting to malaria vaccines
2020
Immunology and Cell Biology
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., who report that low levels of antigen-specific antibodies in serum can limit the boosting of antibody and B-cell responses following immunization with live attenuated malaria sporozoites. ...
This opens new avenues for further research to evaluate antibody feedback in human vaccine studies, particularly in malaria-exposed populations. ...
Limited immune boosting was not due to an intrinsic deficit of the memory B cell response, but was instead due to antibody feedback mediated by circulating anti-CSP antibodies in the serum 7 . ...
doi:10.1111/imcb.12415
pmid:33152796
fatcat:ap54jjp5pvgufmwq7taz2mtdje
Immunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naïve and Adenovirus (Ad5) immune mice
2012
Malaria Journal
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Results: In Ad5 naïve animals, use of Ad4-CSP priming vaccinations followed by boosting with Ad5-CSP (Ad4-CSP/ Ad5-CSP) maximally increased the numbers of CSP specific cytokine secreting cytotoxic T cells ...
The Ad4-CSP/Ad5-CSP regimen also induced equivalent levels of CSP specific cell killing as did homologous prime-boost vaccinations with Ad5-CSP, despite stimulating lower numbers of CSP specific cytotoxic ...
Methods
Vector construction The open reading frame (ORF) of the P. falciparum CSP gene, composed of a codon optimized consensus of several P. falciparum CSP sequences, was incorporated into an E1, E3 ...
doi:10.1186/1475-2875-11-209
pmid:22720732
pmcid:PMC3472263
fatcat:rgioatm765eqlgfoaajbap6jay
A VAR2CSA:CSP conjugate capable of inducing dual specificity antibody responses
2017
African Health Sciences
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Immunogenicity and quality of antibody responses induced by the conjugate vaccine, as well as a control CSP-SpyCatcher vaccine, was tested in BALB/c mice. ...
Results: Serum samples obtained from mice immunized with the conjugate vaccine were able to recognize both untagged DBL1x-DBL2x-ID2a as well as CSP antigen. ...
Anti-CSP IgG titers in sera (n = 5) 2 obtained from mice immunized (prime-boost-boost) with 5 μg of either DBL1x-DBL2x-3 ID2a:CSP (filled circles) or CSP-SpyCatcher (open squares), using Aluminium hydroxide ...
doi:10.4314/ahs.v17i2.11
pmid:29062332
pmcid:PMC5637022
fatcat:s353u3min5elfcgodz5h3d46le
Co-expression of Interleukin-15 Enhances the Protective Immune Responses Induced by Immunization with a Murine Malaria MVA-Based Vaccine Encoding the Circumsporozoite Protein
2015
PLoS ONE
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Importantly, the levels of total anti-CSP IgG were elevated about 100-fold for the MVA-CSP/IL15 immunized group compared to mice immunized with the MVA-CSP construct that does not express IL-15. ...
with an MVA vaccine expressing only CSP or naïve controls. ...
MVA-CSP/IL15 vaccinated (closed circles), MVA-CSP vaccinated (open triangle) and naïve/PBS control (open circles) mice were infected intravenously with PyNL SPZ and parasitemias were evaluated by blood ...
doi:10.1371/journal.pone.0141141
pmid:26505634
pmcid:PMC4624717
fatcat:6njxrraoabbvnl5kxbrwd7ar5a
PROCEEDINGS the1st Italian-Egyptian Solar Energy Workshop.pdf
[article]
2016
Figshare
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The discussion table dedicated to CSP and involving private Italian and Egyptian Enterprises was to provide a boost to the start of industrial activities associated with the CSP in Egypt. ...
Following the "Science Day" event held on 15 June 2011,the workshop gathered together industries involved in the development and implementation of Concentrated solar power (CSP). ...
The discussion table dedicated to CSP and involving private Italian and Egyptian Enterprises was to provide a boost to the start of industrial activities associated with the CSP in Egypt. ...
doi:10.6084/m9.figshare.3969033.v1
fatcat:byhbu5dcpffvbelv562lklxog4
Microcrystalline Tyrosine (MCT®): A Depot Adjuvant in Licensed Allergy Immunotherapy Offers New Opportunities in Malaria
2017
Vaccines
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pronounced if CSP was formulated in MCT. ...
To this end, we formulated the circumsporozoite protein (CSP) of P. vivax in MCT and compared the induced immune responses to CSP formulated in PBS or Alum. ...
C57BL/6 mice were immunized with 5 μg CSP + 2% MCT or only CSP two times, prime (day 0) and boost (day 14); and blood was taken weekly from day 0 (before the prime) until day 28, two weeks after the boost ...
doi:10.3390/vaccines5040032
pmid:28953265
pmcid:PMC5748599
fatcat:mhmtqicihnfdle3uv3goqb36g4
Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional outcomes
2017
Malaria Journal
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One vaccine was a soluble recombinant protein (CSP) and the other was the same CSP covalently conjugated to the Qβ phage particle (Qβ-CSP). ...
While mice failed to discern differences between the protective efficacy of CSP versus Qβ-CSP vaccine following direct challenge with transgenic Plasmodium berghei parasites, rhesus serum from the Qβ-CSP-vaccinated ...
In mice, successive doses of Qβ-CSP and CSP boosted titres but little or no boosting was observed beyond the second dose in rhesus. ...
doi:10.1186/s12936-017-1766-3
pmid:28288639
pmcid:PMC5347822
fatcat:t6cd6t3uabbsrmobxkruut34tm
Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria
2006
Infection and Immunity
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This CSP-specific response could be significantly enhanced by prime-boost immunization with recombinant ACT in combination with anti-CTLA-4 during the boost immunization. ...
Recombinant detoxified ACT containing an epitope of the Plasmodium berghei circumsporozoite protein (CSP), indeed, induced a specific CD8 ؉ T-cell response in immunized mice after a single application, ...
Mice were treated with PBS, anti-CTLA-4, or a prime-boost regimen with ACT-CSP with or without anti-CTLA-4 during the boost. ...
doi:10.1128/iai.74.4.2277-2285.2006
pmid:16552058
pmcid:PMC1418933
fatcat:42ehat4pz5co3itdo2bz4lfos4
IMRAS—Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS
2021
PLoS ONE
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IFN-γ and IL2 responses to TRAP, CelTOS and CSP occurred only in protected subjects. ...
Peripheral IFN-γ, IL2, and IFN-γ+IL2 responses were short-lived and low by 27 weeks post-CHMI but were restored by boosting. ...
Protected subjects (closed symbols), non-protected subjects (open symbols). ...
doi:10.1371/journal.pone.0256396
pmid:34415964
pmcid:PMC8378721
fatcat:emtcm4wb2rcinpo23srnkc4wb4
DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity
2013
PLoS ONE
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Ex vivo IFN-c ELISpot responses after Ad boost were modest (CSP geometric mean spot forming cells/million peripheral blood mononuclear cells 86, range 13-408; AMA1 348, range 88-1270) and were highest ...
Citation: Chuang I, Sedegah M, Cicatelli S, Spring M, Polhemus M, et al. (2013) DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with ...
For the nonprotected volunteers, suspected outliers and outliers are represented as open and filled dots, respectively. ...
doi:10.1371/journal.pone.0055571
pmid:23457473
pmcid:PMC3573028
fatcat:yvb5fpgyq5df3a4njmria4p6uy
Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
2021
Malaria Journal
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Natural exposure induces anti-CSP IgM antibodies in children, which increases with age, but does not induce substantial levels of anti-CSP IgG antibodies. ...
In contrast, there were no measurable anti-CSP IgG antibodies among the controls. ...
Similarly, the minimal boosting of the vaccine-induced anti-CSP IgM Abs seen in this study can be explained by the Abs homeostatic mechanism that prevents overproduction by boosting. ...
doi:10.1186/s12936-021-03961-2
pmid:34856981
pmcid:PMC8641151
fatcat:uoco23qewngvjntojbp7mrhdcm
A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults
2021
PLoS ONE
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Methodology This was an open label, randomized Phase 1 trial, assessing safety, tolerability, and VE against CHMI in healthy, malaria naïve adults. ...
to CSP, AMA1 and TRAP) that were not associated with protection. ...
It is an open label design as subjects were aware if they were receiving a vaccine despite being randomized to either the CA or CAT groups. ...
doi:10.1371/journal.pone.0256980
pmid:34495988
pmcid:PMC8425539
fatcat:ucqbqmmh5jb5bo3jq4z3bfu3be
A Bibliometric Analysis and Benchmark of Machine Learning and AutoML in Crash Severity Prediction: The Case Study of Three Colombian Cities
2021
Sensors
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three case studies using open data portals belonging to the cities of Medellín, Bogotá, and Bucaramanga in Colombia. ...
Then, we compared AutoML (AutoGluon, Auto-sklearn, TPOT) and ML (CatBoost, Decision Tree, Extra Trees, Gradient Boosting, Gaussian Naive Bayes, Light Gradient Boosting Machine, Random Forest) methods in ...
Gaussian Naive Bayes, Light Gradient Boosting Machine, Random Forest) methods in three case
studies using open data portals belonging to the cities of Medellín, ...
doi:10.3390/s21248401
pmid:34960494
pmcid:PMC8708527
fatcat:luyq6542wzhgxeyvjpko5xydvy
Compact self-powered synchronous energy extraction circuit design with enhanced performance
2018
Smart materials and structures (Print)
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The parasitic capacitance is reduced to half with boosted performance while the components are reduced with cost saved. ...
A boost of 37.8% is found. ...
However, for the case of C 0 =50nF, the power boost still reaches 19.4%. The influence of the original open-circuit voltage magnitude V oc,org is also studied for the generator with C 0 =14nF. ...
doi:10.1088/1361-665x/aab339
fatcat:55pccyccmzcvrgzne4jhmvi33q
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