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Prognosis analysis of necroptosis-related genes in colorectal cancer based on bioinformatic analysis
2022
Frontiers in Genetics
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Colorectal cancer (CRC) is one gastrointestinal malignancy, accounting for 10% of cancer diagnoses and cancer-related deaths worldwide each year. ...
The differentially expressed necroptosis-related genes (DENRGs) were sorted out between tumor and normal tissues. ...
Acknowledgments We also thank for the cell line of NCM460 which was given generously by Jiangsu Cancer Hospital Laboratory and support from the central laboratory of the Affiliated Jiangning Hospital of ...
doi:10.3389/fgene.2022.955424
pmid:36046241
pmcid:PMC9421078
fatcat:cdlelirw3ncohobpvxfdskpfoy
Bioinformatics Analysis of RNA-seq Data Reveals Genes Related to Cancer Stem Cells in Colorectal Cancerogenesis
2022
International Journal of Molecular Sciences
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Using bioinformatics and RNA-seq data of normal mucosa, colorectal adenoma, and carcinoma (n = 106) from GEO and TCGA, we identified candidate CSC genes and analyzed pathway enrichment analysis (PEI) and ...
Cancer stem cells (CSC) play one of the crucial roles in the pathogenesis of various cancers, including colorectal cancer (CRC). ...
Our previous studies showed that genes related to CSC-like cells might be also involved in development and progression of colorectal cancer (CRC) [4, 5] . ...
doi:10.3390/ijms232113252
pmid:36362041
pmcid:PMC9654446
fatcat:d6cpwq6rkbby3h7iuz4syikjqm
Screening and identification of hub gene and differential gene and mutation sequence analysis of related genes in colorectal cancer based on bioinformatics analysis
2022
Journal of Gastrointestinal Oncology
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The key genes closely related to colon cancer were effectively screened by the bioinformatics method, which provided a theoretical basis for further study of its mechanism. ...
The expression of copper death-related genes was significantly correlated with the correlation coefficient of colon cancer (P<0.01). ...
Acknowledgments Funding: The study was supported by the National Natural Science Foundation of China (No. 82260938) and the Jiangxi Natural Science Foundation (No. 2020BABL206135). ...
doi:10.21037/jgo-22-1131
pmid:36636081
pmcid:PMC9830333
fatcat:ioq5aq4hwvag7m2vdxutreuguy
Identification of genes and cellular response factors related to immunotherapy response in mismatch repair-proficient colorectal cancer: a bioinformatics analysis
2022
Journal of Gastrointestinal Oncology
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Mismatch repair-proficient (pMMR) colorectal cancers (CRCs) are thought to be primarily resistant to immune checkpoint inhibitor (ICI) monotherapy. ...
This analysis might be valuable for the selection of patients who might benefit from immunotherapeutic strategies. ...
Acknowledgments We would like to thank the contributions of the GEO and TCGA for providing free access to online data. Funding: None. ...
doi:10.21037/jgo-22-1070
pmid:36636048
pmcid:PMC9830321
fatcat:6p7yae2nefbkbmoqmrhkpaclvq
Screening of ferroptosis-related genes with prognostic effect in colorectal cancer by bioinformatic analysis
2022
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To summary, we established a prognostic model of colorectal cancer (CRC) based on ferroptosis-related genes and further explored the relationship between these genes with immune microenvironment. ...
Colorectal cancer (CRC) remains a common malignant tumor of digestive tract with high incidence rate and high mortality in the worldwide. ...
Functional analysis of ferroptosis-related genes The GO and Kyoto Encyclopedia of Genes (KEGG) analysis were performed using a gene annotation and analysis resource Metascape (https://metascape.org/gp/ ...
doi:10.3389/fmolb.2022.979854
pmid:36203871
pmcid:PMC9531163
fatcat:gfwikxvgpfasxgslx66fzilue4
Bioinformatics Analysis of Prognosis-Related Genes and Expression of CXCL8 in Colorectal Cancer
2022
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Colorectal cancer (CRC), one of the main causes of death, remains a leading cause of mortality in gastrointestinal cancer and tends to affect the younger generation. ...
However, the pathological process of colorectal cancer is unclear. Exploring potential pathogenesis and therapeutic targets of CRC is significant as its high prevalence and high mortality. ...
of Soochow University (a team project of application innovation of nuclear technology in medicine) (serial number: XKTJHTD2021001) and the Priority Academic Program Development of Jiangsu Higher Education ...
doi:10.1155/2022/3149887
pmid:35845924
pmcid:PMC9279071
fatcat:t44s56niwnekhb7f5nvnsdetpu
Bioinformatics analysis of SRSF1‑controlled gene networks in colorectal cancer
2017
Oncology Letters
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From overlapping the analysis of 2,678 SRSF1-related genes and 3,625 colorectal cancer genes in GeneCards, 468 genes were identified as SRSF1-related colorectal cancer genes. ...
Collectively, the bioinformatics analysis of the present study indicated that SRSF1 may have key functions in the progression and development of colorectal cancer. ...
Acknowledgements The present study was supported by the National Natural Science Foundation of China (grant no. 31400726) and the ...
doi:10.3892/ol.2017.6900
pmid:29113173
pmcid:PMC5656040
fatcat:enmjuvobpjabxdpk7qs63boxie
Bioinformatics Analysis and Validation of the Expressed Sequences Tag in Human Colorectal Adenocarcinoma
2009
Gastroenterology Research
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This study was to investigate some new pathological genes in colorectal adenocarcinoma of human. ...
From differentially expressed 86 expressed sequence tags (EST), 10 EST of the SSH were selected as seed sequence for bioinformatics analyses, semi-quantitative RT-PCR and PCR-sequencing . ...
The authors declare no commercial associations or conflict of interests related to this article. ...
doi:10.4021/gr2009.04.1287
pmid:27956963
pmcid:PMC5139827
fatcat:4py64rucbfb25amonqxkfed5re
CLCA4 and MS4A12 as the significant gene biomarkers of primary colorectal cancer
2020
Bioscience Reports
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Conclusion: The research of DEGs in PCRC (53 DEGs, 10 hub genes, especially CLCA4 and MS4A12) and related signaling pathways is conducive to the differential analysis of the molecular mechanism of PCRC ...
Primary colorectal cancer (PCRC) is a common digestive tract cancer in the elderly. However, the treatment effect of PCRC is still limited, and the long-term survival rate is low. ...
Zhang et al. found genes related to hepatocellular carcinoma by bioinformatics analysis. ...
doi:10.1042/bsr20200963
pmid:32797167
pmcid:PMC7441370
fatcat:npdw6ltrmrf2zncc53w2iblx3m
Identification of biomarkers for the diagnosis and treatment of primary colorectal cancer based on microarray technology
2020
Translational Cancer Research
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Ten hub genes were found from the genomic samples of patients with PCRC and normal controls by bioinformatics analysis. ...
Primary colorectal cancer (PCRC) is one of the most common malignant tumors in clinic, and is characterized by high heterogeneity occurring between tumors and intracellularly. ...
article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of ...
doi:10.21037/tcr-19-2290
pmid:35117711
pmcid:PMC8798183
fatcat:ztvj56z5ibhfdeheoflsmzmfny
Comprehensive Analysis of Therapy-Related Messenger RNAs and Long Noncoding RNAs as Novel Biomarkers for Advanced Colorectal Cancer
2019
Frontiers in Genetics
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Bioinformatics analysis showed therapy-related mRNAs were associated with nucleosome assembly, chromatin silencing at recombinant DNA, negative regulation of gene expression, and DNA replication. ...
Colorectal cancer (CRC) is one of the most common types of human cancers. However, the mechanisms underlying CRC progression remained elusive. ...
Bioinformatics Analysis for Related Long Noncoding RNAs and Small Nucleolar RNAs in Locally Advanced Colorectal Cancer Then, bioinformatics analysis for related lncRNAs and snoRNAs in LACC was performed ...
doi:10.3389/fgene.2019.00803
pmid:31850052
pmcid:PMC6900565
fatcat:ooj24fht4vhwbam54mbqsr3bna
CA9 and CHRNB1 were correlated with perineural invasion in Taiwanese colorectal cancer patients
2013
Biomarkers and Genomic Medicine
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by microarray and bioinformatics analysis. ...
Colorectal cancer (CRC) is a significant public health problem worldwide. ...
by microarray and bioinformatics analysis. ...
doi:10.1016/j.bgm.2013.07.001
fatcat:xfam3fkdszcnjgq466gf5x7lo4
Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach
2021
Gastroenterology and hepatology from bed to bench
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The aim of this study was to integrate both coding and non-coding available microarray data in the development of colorectal cancer (CRC) with bioinformatics analyses to attain a more inclusive pathobiologic ...
Microarray data was retrieved from the Gene Expression Omnibus (GEO) database and analyzed. Several bioinformatics tools and databases were applied for further elucidation. ...
Conflict of interests The authors declare that they have no conflict of interest. ...
pmid:33968341
pmcid:PMC8101520
fatcat:spa2rutujzfeteaga6o32tfgoi
Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation
2021
Cancer Cell International
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Results Our bioinformatics analysis determined 11 key mRNAs, 9 hub miRNAs, and 18 lncRNAs which among them 2 coding RNA genes including DDIT4 and SULF1 as well as 3 non-coding RNA genes including TPTEP1 ...
Expression of several of these RNAs were measured by RT-qPCR in 48 tissues from CRC patients as well as in colorectal cancer stem cell-enriched spheroids derived from the HT-29 cell line. ...
Carlos Cordon-Cardo (University of Icahn School of Medicine) and Dr. Fatemeh Fattahi (University of Michigan Medical School) for their feedback and pre-reviewing our article. ...
doi:10.1186/s12935-021-02002-x
pmid:34107956
fatcat:o7doea6hdjah7nfm722of7ttai
Diagnostic genes and immune infiltration analysis of colorectal cancer determined by LASSO and SVM machine learning methods: a bioinformatics analysis
2022
Journal of Gastrointestinal Oncology
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The aim of this study is to identify diagnostic genes of colorectal cancer by using machine learning methods. ...
Genetic factors account for approximately 35% of colorectal cancer risk. ...
Acknowledgments Funding: This work was supported by the Natural Science Foundation of Liaoning Province (No. 2021-MS-330). ...
doi:10.21037/jgo-22-536
pmid:35837194
pmcid:PMC9274036
fatcat:5h5rywcncvhglbaka54inphhk4
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