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Digital pathology in personalized cancer therapy
2012
Folia Histochemica et Cytobiologica
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Digital microscopy is an important tool for surgical pathologists. ...
Digital image analysis is now available in a variety of platforms to improve quantification performance of diagnostic pathology. ...
Digital microscopy creates a digital version of whole glass slides (WSI, Whole Slide Image), which can be dynamically viewed, navigated and magnified on a monitor across a computer network. ...
doi:10.5603/fhc.2011.0080
fatcat:jazh6hqevrhvtpoqzbv3nrhrbu
Use of Web-based training for quality improvement between a field immunohistochemistry laboratory in Nigeria and its United States–based partner institution
2013
Annals of Diagnostic Pathology
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We found Web-based conferences and digital microscopy useful and cost-effective tools for quality assurance of IHC, consultation, and collaboration between distant laboratories. ...
Two hundred and thirty-two breast tumor blocks were evaluated for estrogen receptors (ERs), progesterone receptors (PRs), and HER2 status at both laboratories using tissue microarray technique. ...
In more advanced centers, highspeed, automated whole-slide imaging systems are being used to generate digital images of sufficient quality for pathologists to make reliable diagnostic decisions [21] . ...
doi:10.1016/j.anndiagpath.2013.07.003
pmid:24095629
fatcat:uvdtwfdhhzbath4ocmbiytoopi
Digital Technology in Diagnostic Breast Pathology and Immunohistochemistry
2021
Pathobiology (Basel)
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Digital technology has been used in the field of diagnostic breast pathology and immunohistochemistry (IHC) for decades. ...
and eosin-stained digitalized images. ...
quality control and quality assurance mea-
sures, (iv) audits, training, and validation processes, (v) In breast pathology, IHC is used for diagnostic pur-
slide sharing, and (vi) facilitating junior ...
doi:10.1159/000521149
pmid:34969036
fatcat:rx4rloc5vzch5cc2b7tlqcfxkq
Review of imaging solutions for integrated quantitative immunohistochemistry in the Pathology daily practice
2010
Folia Histochemica et Cytobiologica
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IHC interpretation based in whole slide imaging or virtual microscopy is of special interest. ...
The objective of this work is to review the different computerbased programs for automatic immunohistochemistry and Fluorescence In Situ Hybridization (FISH) evaluation. ...
Unlike manual reading, an automated analysis revealed that patients with breast tumours expressing normal levels of HER2 also showed a significantly worse outcome. ...
doi:10.2478/v10042-008-0114-4
pmid:20164017
fatcat:jmwzahchwvecvbrhlhopkokvdi
Tissue microarrays: leaping the gap between research and clinical adoption
2013
Personalized Medicine
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Another study by Terry et al. used TMAs as part of an implementation of the Canadian External Quality Assurance program for breast cancer testing [61] . ...
Requirement for automated & objective image-analysis tools The development of next-generation tissue-based diagnostic tests in the clinical laboratory will be critically reliant upon automated imaging ...
doi:10.2217/pme.13.42
pmid:29758838
fatcat:iyauigxkara5llzegnv32u5xqe
Nanogenomics and Artificial Intelligence: A Dynamic Duo for the Fight Against Breast Cancer
2021
Frontiers in Molecular Biosciences
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Large volume of data generated by digitalized mammogram or whole-slide images can be interoperated through advanced machine learning. ...
Thus, theoretically, through nanogenomicas, a profile of each breast tumor sub-type, estrogen receptor status, and potential metastasis site can be constructed. ...
DL models are also being developed for digitalized hematoxylineosin (H&E)-stained whole-slide images. ...
doi:10.3389/fmolb.2021.651588
pmid:33937332
pmcid:PMC8082244
fatcat:46ff4ptyxbgrnjlq5bqoneioyq
Digital Imaging in Pathology: Whole-Slide Imaging and Beyond
2013
Annual Review of Pathology
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Digital imaging in pathology has undergone an exponential period of growth and expansion catalyzed by changes in imaging hardware and gains in computational processing. ...
Today, digitization of entire glass slides at near the optical resolution limits of light can occur in 60 s. Whole slides can be imaged in fluorescence or by use of multispectral imaging systems. ...
DIGITAL PATHOLOGY AND WHOLE-SLIDE IMAGING SYSTEMS: AN OVERVIEW Since the development of the first automated, high-resolution whole-slide imaging (WSI) system by Wetzel and Gilbertson in 1999 (described ...
doi:10.1146/annurev-pathol-011811-120902
pmid:23157334
fatcat:g7ba47thmjfvhbos7dxke4nsoy
Digital Image Analysis of Ki-67 Stained Tissue Microarrays and Recurrence in Tamoxifen-Treated Breast Cancer Patients
2020
Clinical Epidemiology
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We hypothesized that digital image analysis (DIA) of Ki-67 can be used to evaluate proliferation in breast cancer tumors, and that Ki-67 may be associated with tamoxifen resistance in early-stage breast ...
Our findings suggest that Ki-67 digital image analysis in TMAs is not associated with increased risk of recurrence among tamoxifen-treated ER-positive breast cancer or ER-negative breast cancer patients ...
Furthermore, the authors thank the Danish Breast Cancer Group for access to its registry data. ...
doi:10.2147/clep.s248167
pmid:32801916
pmcid:PMC7383278
fatcat:sjwf72pnljeupgzobr5x7chneu
Automated measurement of estrogen receptor in breast cancer: a comparison of fluorescent and chromogenic methods of measurement
2016
Laboratory Investigation
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Whereas FDA-approved methods of assessment of estrogen receptor (ER) are 'fit for purpose', they represent a 30-year-old technology. ...
In 10 cases, the Aperio nuclear algorithm labeled the nuclei as negative; in 1 case, the AQUA score was just under the cutoff for positivity (determined by an Index TMA). ...
ACKNOWLEDGMENTS This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. ...
doi:10.1038/labinvest.2016.73
pmid:27348626
pmcid:PMC5008858
fatcat:xiho4puidzfdva6rjqw5xxmvw4
Artificial intelligence in breast cancer imaging: risk stratification, lesion detection and classification, treatment planning and prognosis—a narrative review
2022
Exploration of Targeted Anti-tumor Therapy
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The advent of artificial intelligence (AI) represents a real game changer in today's landscape of breast cancer imaging. ...
The main challenges to the development of AI tools are the huge amounts of high-quality data required to train and validate these models and the need for a multidisciplinary team with solid machine-learning ...
An AI-assisted lesion segmentation tool has been applied to automated whole breast US by Lee et al. ...
doi:10.37349/etat.2022.00113
pmid:36654817
pmcid:PMC9834285
fatcat:orelpodas5hpdogdy5lajvui2y
Cultivating Clinical Clarity through Computer Vision: A Current Perspective on Whole Slide Imaging and Artificial Intelligence
2022
Diagnostics
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control and primary diagnosis applications. ...
Ushered into the fray of modern laboratory medicine are digital imaging devices and machine-learning (ML) software fashioned to mitigate challenges, e.g., practitioner shortage while preparing clinicians ...
Acknowledgments: Thank you to David Kellough, who provided photos of digital pathology integration at the Ohio State University (Columbus, OH, USA). ...
doi:10.3390/diagnostics12081778
pmid:35892487
pmcid:PMC9332710
fatcat:4cgjt665zbgidnpoeklwsmr6iy
Clinical Applications of Whole-slide Imaging in Anatomic Pathology
2017
Advances in Anatomic Pathology
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The development of whole-slide imaging has paved the way for digitizing of glass slides that are the basis for surgical pathology. ...
The opportunities for applications of image analysis tools in a workflow will be changed by integration of whole-slide imaging into routine diagnosis. ...
Algorithms have already been created for automated calculation of the breast biomarkers estrogen receptor, progesterone receptor, and Her2. ...
doi:10.1097/pap.0000000000000153
pmid:28590953
fatcat:vcdmcwrygrhyfj6iwn2jyikpnm
Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner
2015
PLoS ONE
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We evaluate the performance of the device in the digital assessment of estrogen receptor-alpha (ER) expression in breast cancer samples. ...
Materials and Methods A total of 170 samples of human breast carcinoma, immunostained for ER expression, were digitized with a high-end slide-scanner and the point-of-care microscope. ...
Yinhai Wang for helpful discussions, constructive feedback and assistance with the image analysis. ...
doi:10.1371/journal.pone.0144688
pmid:26659386
pmcid:PMC4684374
fatcat:4yy4x5tyxjfxtknzgk2ri6mfvi
Informatics
2015
Laboratory Investigation
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Design: 104 consecutive bone marrow biopsies were digitally scanned at 20x magnifi cation using an Aperio CS whole slide scanner. 89 cases had numeric manual cellularity scores and qualifi ed for comparison ...
Adoption of digital imaging in the clinical laboratory also provides advantages including long term archival and quality assurance measures. ...
Whole slide imaging technology is used for the telepathology consultation service. ...
doi:10.1038/labinvest.2015.17
fatcat:74eygyy7o5gkrhizoootoyfol4
Position paper: recommendations for a digital mammography quality assurance program V4.0
2017
Australasian physical & engineering sciences in medicine
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At this time the technology of digital imaging is undergoing significant development and there is still a lack of full international consensus about some of the detailed Quality Control (QC) tests that ...
For completeness, this document also includes a review of the QA programs required for the various types of digital biopsy units used in mammography. ...
Facility Quality Control Procedures
3.1 Introduction As in screen/film mammography, facility quality control procedures for digital mammography systems are essential for ensuring production of high quality ...
doi:10.1007/s13246-017-0583-x
pmid:28914430
fatcat:huxzxhkpbngzxjv72nkspd64vy
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