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Aging Brain Mechanics: Progress and Promise of Magnetic Resonance Elastography
2021
NeuroImage
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Magnetic resonance elastography (MRE) has recently emerged as a reliable, high-resolution, and especially sensitive technique that can noninvasively characterize tissue biomechanical properties (i.e., ...
In this article, we detail how progress in brain MRE has provided unique insights into healthy brain aging, neurodegeneration, and structure-function relationships. ...
Acknowledgments This work was supported by grants from the National Institutes of Health ( R01-AG058853 and R01-EB027577 ). ...
doi:10.1016/j.neuroimage.2021.117889
pmid:33617995
pmcid:PMC8251510
fatcat:43ld36h5nzgvvdxk52arbfx4su
Mechanical Property Based Brain Age Prediction using Convolutional Neural Networks
[article]
2023
biorxiv/medrxiv
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Magnetic resonance elastography (MRE) is a phase contrast MRI technology that uses external palpations to measure brain mechanical properties. ...
After training, the network maps the measurements and other inputs to a brain age prediction. We found high performance using the 3D maps of various mechanical properties to predict brain age. ...
Magnetic resonance elastography (MRE) noninvasively images brain mechanical properties in vivo, which are sensitive to degeneration in the brain caused by aging and disease (Murphy et al., 2019) . ...
doi:10.1101/2023.02.12.528186
pmid:36824781
pmcid:PMC9948973
fatcat:mjqfhgxcpzcabctgxzfhtwjpvu
Mechanobiology of the brain in ageing and Alzheimer's disease
2020
European Journal of Neuroscience
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Here, we discuss the complex and inhomogeneous mechanical structure of CNS tissue, as revealed by recent mechanical measurements on the brain and spinal cord, using techniques such as magnetic resonance ...
Moreover, ageing, traumatic brain injury, demyelination and neurodegeneration can perturb the mechanical properties of brain tissue and trigger mechanobiological signalling pathways in neurons, glia, and ...
E.M. is a recipient of Cancer Research UK Multidisciplinary [C57744/ A22057] and CRUK-UCL Centre [C416/A25145] Awards. The authors wish to thank the University of Brighton for supporting this project. ...
doi:10.1111/ejn.14766
pmid:32356339
fatcat:lbuhtnqyafhstpfwr52wabbssq
Editorial: Advances in Brain Mechanics
2021
Frontiers in Mechanical Engineering
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The latest developments in this direction enable the live assessment of mechanical properties using multi-modal magnetic resonance elastography (MRE), as presented in Herthum et al. ...
Common techniques include large-strain compression, tension, and shear experiments, which are typically performed ex vivo, as well as indentation measurements and magnetic resonance elastography, which ...
This study demonstrates how the integration of techniques from computational biomechanics and medical data assessed in the clinic (e.g., magnetic resonance imaging) can help predict injuries, support early ...
doi:10.3389/fmech.2021.803151
fatcat:dkxiuuob4za6pnig566nlombwy
Measurement of Mechanical Properties of Natural and Engineered Implants
2016
Advances in Tissue Engineering & Regenerative Medicine Open Access
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There are several fairly new methods that have been evaluated in the literature such as magnetic resonance elastography (MRE), ultrasound elastography (UE), optical coherence tomography (OCT), ocular response ...
analysis (ORA), optical coherence elastography (OCE) and OCT with vibrational analysis that are quite promising. ...
Conflict of interest The author declares no conflict of interest. ...
doi:10.15406/atroa.2016.01.00004
fatcat:lawkuopcdffijee4j6iegj67mm
Tissue mechanics regulate brain development, homeostasis and disease
2017
Journal of Cell Science
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Acknowledgements We thank Jon Muncie and Janna Mouw (both of University of California, San Francisco) for helpful comments on the Commentary. ...
magnetic resonance elastography, could serve as a noninvasive diagnostic tool (Murphy et al., 2011) . ...
)
Nanometer Requires specialized skillset,
expensive equipment,
unreliable at E<100 Pa
Gavara, 2016
Magnetic resonance
elastography (MRE)
Shear waves of a known
frequency are applied to the ...
doi:10.1242/jcs.191742
pmid:28043968
pmcid:PMC5394781
fatcat:kybu76z45rhhznb6oravudj3dy
Fifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
2019
Archives of Computational Methods in Engineering
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Computational simulations-based on the field equations of nonlinear continuum mechanics-can provide important insights into the underlying mechanisms of brain injury and disease that go beyond the possibilities ...
progression and estimating injury risk to planning surgical procedures. ...
of chronic traumatic encephalopathy" and the Humboldt Research Award to E.K. ...
doi:10.1007/s11831-019-09352-w
fatcat:z3g2pr2zpzajzmmktnrtqqsg3y
Brain age estimation is a sensitive marker of processing speed in the early course of multiple sclerosis
[article]
2019
biorxiv/medrxiv
pre-print
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The difference between estimated and chronological brain age was calculated (brain age gap). Tests of memory, attention and executive functions were performed. ...
Results: LME models revealed a significant association between the Color Naming condition of Color-Word Interference Test and brain age gap (t=2.84, p=0.005). ...
We acknowledge the collaboration with members of the Multiple Sclerosis Research Group at the University of Oslo and Oslo University hospital, especially Professor Elisabeth G. Celius. ...
doi:10.1101/651521
fatcat:h46va3z6r5cwdicg4daues7odm
Mechanics of the brain: perspectives, challenges, and opportunities
2015
Biomechanics and Modeling in Mechanobiology
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The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. ...
All about the brain. John Cleese. A. Goriely (physiological activity of the brain. ...
A promising novel approach to characterize the mechanical properties of living brain tissue is magnetic resonance elastography (Kruse et al. 2008; Sack et al. 2008) . ...
doi:10.1007/s10237-015-0662-4
pmid:25716305
pmcid:PMC4562999
fatcat:fzay725anncctcjtuj2r2f2xfq
Contemporary image-based methods for measuring passive mechanical properties of skeletal muscles in vivo
2019
Journal of applied physiology
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Elastography measurements can provide in vivo maps of passive muscle mechanical parameters, and both MRI and ultrasound methods are available (magnetic resonance elastography and ultrasound shear wave ...
; diffusing tensor imaging; elastography; magnetic resonance imaging; ultrasound ...
MAGNETIC RESONANCE ELASTOGRAPHY OF SKELETAL MUSCLE Methods. ...
doi:10.1152/japplphysiol.00672.2018
pmid:30236053
fatcat:ivevskrxqndjhn6t6r5cjuwqzy
Local mechanical properties of white matter structures in the human brain
2013
NeuroImage
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The noninvasive measurement of the mechanical properties of brain tissue using magnetic resonance elastography (MRE) has emerged as a promising method for investigating neurological disorders. ...
To date, brain MRE investigations have been limited to reporting global mechanical properties, though quantification of the stiffness of specific structures in the white matter architecture may be valuable ...
Acknowledgments The Biomedical Imaging Center of the Beckman Institute for Advanced Science and Technology and the Richard W. ...
doi:10.1016/j.neuroimage.2013.04.089
pmid:23644001
pmcid:PMC3676712
fatcat:sjt6ogmto5e6tpw2xtoexe5ldm
Clinical studies of magnetic resonance elastography from 1995 to 2021: Scientometric and visualization analysis based on CiteSpace
2022
Quantitative Imaging in Medicine and Surgery
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The USA and the Mayo Clinic had the highest betweenness centrality among countries and institutions, respectively, and played an important role in the field of MRE. ...
The 3 most productive countries were the USA (n=631), Germany (n=202), and France (n=134), and the 3 most productive institutions were the Mayo Clinic (n=240), Charité (n=131), and the University of Illinois ...
resonance elastography 9 24 1 1997 Contraction contraction; muscle; mechanical properties; Magnetic resonance imaging; elastography MRE, magnetic resonance elastography; LLR, log-likelihood ratio; MR, ...
doi:10.21037/qims-22-207
fatcat:6j5ztia6lbhgtg33dkp3oqfzzu
Metabolic imaging in obesity: underlying mechanisms and consequences in the whole body
2015
Annals of the New York Academy of Sciences
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and browning/ whitening; (3) ultrasounds to examine liver steatosis, stiffness, and inflammation; and (4) magnetic resonance techniques to assess blood oxygenation levels in the brain, liver stiffness ...
and treat obesity according to causative mechanisms. ...
until adulthood and then progressively decrease throughout aging. 137 A steadily growth in the amount of fat in the pancreas occurred from birth to 90 years of age, leading to an almost complete fat ...
doi:10.1111/nyas.12880
pmid:26335600
fatcat:ce2a6tiedbbepgz4cs6fko2pva
Mechanical Properties in the Glioma Microenvironment: Emerging Insights and Theranostic Opportunities
2022
Frontiers in Oncology
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the mechanical properties of the microenvironment to halt disease progression have the potential to be promising treatment strategies based on early studies. ...
Gliomas represent the most common malignant primary brain tumors, and a high-grade subset of these tumors including glioblastoma are particularly refractory to current standard-of-care therapies including ...
Paul Camarata, MD, Chair, Department of Neurosurgery for supporting the publication costs. ...
doi:10.3389/fonc.2021.805628
pmid:35127517
pmcid:PMC8813748
fatcat:y7tztvbynreynap7v75mdkpytu
Viscoelasticity Imaging of Biological Tissues and Single Cells Using Shear Wave Propagation
2021
Frontiers in Physics
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to track shear wave propagation, namely ultrasound, magnetic resonance, optical, and photoacoustic means. ...
Shear wave elastography is a non-invasive imaging technology invented for clinical applications that has shown promise to characterize various tissue viscoelasticity. ...
Aging Brain Mechanics: Progress and Promise of Magnetic Resonance Elastography. ...
doi:10.3389/fphy.2021.666192
fatcat:qvn4pciaxbdbfhynp4spzszrii
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